|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 3 | Relationship Quality in Services Selling:An Interpersonal Influence Perspective显示文摘 | CROSBY LAWRENCE A KENNETH R EVANS DEBORAH COWLES | 1990 | Journal of Marketing1990，，54： | 1 |
| 4 | Relationship Quality in Services Selling:An Interpersonal Influence Perspective显示文摘 | CROSBY L A EVANS K R COWLES D | 1990 | Journal of Marketing1990，54，3： | 1 |
| 5 | Altered bone morphogenetic pro-tein and transforming growth factor-beta signaling in rat models of pul-monary hypertension:potential for activin receptor-like kinase-5 inhi-bition in prevention and progression of disease显示文摘 | Long L Crosby A Yang X | 2009 | Circulation2009，119，4： | 1 |
| 6 | Vibration Control Using Semi-Active Force Generators显示文摘 | Karnopp D Crosby M Harwood R A | 1974 | ASME Journal of Engineering for Industry1974，96，2： | 1 |
| 7 | The static and dynamic characteristics of a two-lobe journal bearing lubricated with couple-stress fluid 显示文摘 | Crosby W A Chetti B | 2009 | Tribology Transactions 52:2 62 - 2682009，2009，： | 1 |
| 8 | Modified discrete ordinates solution of radiative transfer in two-dimensional retangular enclosures显示文摘 | RAMANKUTTY M A CROSBIE A L | 1997 | J Quanti Spectro & Radiative Transfer1997，57，1： | 1 |
| 9 | Genetic mapping ot the dentmogenesm lmpertecta type Ⅱ locus 显示文摘 | Crosby A H Scherpbier-Heddema T Wijmenga C | 1995 | Am dHum Genet1995，57，4： | 1 |
| 10 | Personality subtyping and bulimia nervosa psychopathological and genetic correlates 显示文摘 | Wonderlich S A Crosby R D Joiner T | 2005 | Psychol Med2005，35，5： | 1 |
| 11 | Breeding apples for scab resistance显示文摘 | Crosby J A Janick J Pecknold P C | 1992 | FruitVar1992，46，3： | 1 |
| 12 | Mosses of Europe and the Azores; an annotated list of species, with synonyms from the recent literature显示文摘 | CROSBY M F V CRIMDWELL A C DOLL R | 1981 | Bryol1981，11，： | 1 |
| 13 | p53 binding to target sites is dynamically regulated before and after ionizing radiation-mediated DNA damage 显示文摘 | Crosby ME Oancea M Almasan A | 2004 | J Environ Pathol Toxicol Oncol2004，23，1： | 1 |
| 14 | Relationship quality in services selling:an interpersonal influence perspective显示文摘 | CROSBY L A EVANS K COWLES | | 0，，： | 1 |
| 15 | Pulmonary vascular remodeling correlates with lung eggs and cytokines in murine schistosomiasis显示文摘 | Crosby A Jones F M Southwood M | 2010 | Am J Respir Crit Care Med2010，181，3： | 1 |
| 16 | Relationship Quality in Service Selling : An Interpersonal Influence Perspective 显示文摘 | Crosby L A K Evans D Cowles | 1990 | Journal of Marketing1990，54，： | 1 |
| 17 | Relationshipquality in services selling : An interpersonal influenceperspective显示文摘 | Crosby L A Evans K R Cowles D | 1990 | Journal of Marketing1990，54，3： | 1 |
| 18 | Structure and evolution of the intracratonic Congo Basin显示文摘 | Crosby A G Fishwick S White N | 2010 | Geochemistry Geophysics Geosystems2010，11，6： | 1 |
| 19 | Associations between intemet sex seeking and STI associated risk behaviours among men who have sex with men 显示文摘 | Mettey A Crosby R Dielemente R | 2003 | Sex Transm Infect2003，79，6： | 1 |
| 20 | Physicochemical properties of Australian flours influencing the texture of yellow alkaline noodles显示文摘 | ROSS A S QUAIL K J CROSBIE G B | 1997 | Cereal Chem1997，74，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员