|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 经颅多普勒超声(TCD)的实践标准——第2部分:临床适应证和预期结果显示文摘引言:经颅多普勒(transcranial Doppler,TCD)已被证实为一种安全有效的生理学超声检查技术。尽管成像设备可以在结构影像的基础上显示颅内血流,但成像性双功能超声或非成像性TCD检查提供的最终结果是通过频谱波形来评价生理学血流参数。总结概要:多学科专家小组确定的TCD临床适应证包括:镰状细胞病、恼缺血、右向左分流(right—to—left shunt,RLS)、蛛网膜下腔出血、脑死亡以及围手术期或术中监测。TCD检查可常规应用于住院或门诊患者的一些临床实践活动:通过完整或部分TCD检查以检测正常、狭窄或闭塞的颅内血管和侧支循环来判断动脉闭塞位置,并进一步完善颈动脉超声或无创性血管造影结果;通过血管运动反应性检查来识别首发或复发性卒中的高危患者;通过栓子监测对脑栓塞进行实时检查、定位和量化;在怀疑反常性栓塞或考虑分流封堵术治疗的患者中进行RLS检测;对溶栓治疗进行监测以促进血管再通和检测再闭塞;在血管内支架置入术、颈动脉内膜切除术和心脏外科手术中进行监测以发现围手术期栓塞、血栓形成、低灌注或高灌注。结论:通过界定实践范围,这些标准将在TCD检查的申请、检查和评价过程中给开申请单的医生、发报告的医生以及第三方提供帮助。 | Andrei V. Alexandrov Michael A. Sloan Charles H. Tegeler David N. Newell Alan Lumsden Zsolt Garami Christopher R. Levy Lawrence K.S. Wong Colleen Douville Manfred Kaps 李海峰(译) 李宏(译) 李展秀(译) | 2012 | 国际脑血管病杂志2012，20，1： | 28 |
| 2 | Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer显示文摘Angiogenesis,从先存在的新血容器的形成 vasculature,为许多生理的过程,和异常 angiogenesis 是必要的贡献一些最流行的人的疾病,包括癌症。Angiogenesis 被在 pro-angiogenic 和 anti-angiogenic 信号之间的精细的平衡控制。当发信号的 pro-angiogenic 广泛地被调查了时,怎么发展地调整了,自然地发生的 anti-angiogenic 分子阻止过多的生长脉管并且淋巴管仍然糟糕被理解。在这评论,我们总结上的当前的知识 semaphorins 和他们的受体, plexins 和 neuropilins,控制正常和病理学的 angiogenesis,与在脉管、淋巴的 endothelial 房间表明电路的调整 semaphorin 的 anti-angiogenic 上的一个重音。信息的这新兴的身体可以负担得起机会开发新奇 anti-angiogenic 治疗学的策略。 | Atsuko Sakurai Colleen Doci J Silvio Gutkind | 2012 | Cell Research2012，22，1： | 15 |
| 3 | Switchgrass Biochar Effects on Plant Biomass and Microbial Dynamics in Two Soils from Different Regions显示文摘Biochar amendments to soils may alter soil function and fertility in various ways, including through induced changes in the microbial community. We assessed microbial activity and community composition of two distinct clayey soil types, an Aridisol from Colorado(CO) in the U.S. Central Great Plains, and an Alfisol from Virginia(VA) in the southeastern USA following the application of switchgrass(Panicum virgatum) biochar. The switchgrass biochar was applied at four levels, 0%, 2.5%, 5%, and 10%, approximately equivalent to biochar additions of 0, 25, 50, and 100 t ha-1, respectively, to the soils grown with wheat(Triticum aestivum) in an eight-week growth chamber experiment. We measured wheat shoot biomass and nitrogen(N) content and soil nutrient availability and N mineralization rates, and characterized the microbial fatty acid methyl ester(FAME) profiles of the soils. Net N mineralization rates decreased in both soils in proportion to an increase in biochar levels, but the effect was more marked in the VA soil, where net N mineralization decreased from-2.1 to-38.4 mg kg-1. The 10% biochar addition increased soil p H, electrical conductivity, Mehlichand bicarbonate-extractable phosphorus(P), and extractable potassium(K) in both soil types. The wheat shoot biomass decreased from 17.7 to 9.1 g with incremental additions of biochar in the CO soil, but no difference was noted in plants grown in the VA soil. The FAME recovery assay indicated that the switchgrass biochar addition could introduce artifacts in analysis, so the results needed to be interpreted with caution. Non-corrected total FAME concentrations indicated a decline by 45% and 34% with 10% biochar addition in the CO and VA soils, respectively, though these differences became nonsignificant when the extraction efficiency correction factor was applied. A significant decline in the fungi:bacteria ratio was still evident upon correction in the CO soil with biochar. Switchgrass biochar had the potential to cause short-term negative impacts on plant biomass and alter soil microbial community structure unless measures were taken to add supplemental N and labile carbon(C). | Charlene N.KELLY Francisco C.CALDERóN Verónica ACOSTA-MARTíNEZ Maysoon M.MIKHA Joseph BENJAMIN David W.RUTHERFORD Colleen E.ROSTAD | 2015 | Pedosphere2015，25，3： | 11 |
| 4 | 手足口病急诊留观患儿转归的相关因素分析显示文摘目的探讨儿科手足口病患儿的临床特点及急诊留观患儿转归的危险因素,为手足口病患儿的护理提供依据。方法对2012年8月至2013年3月儿科急诊留观室收治的471例手足口病患儿及同期住院的40例患儿一般资料、临床症状及实验室检查结果进行比较,分析急诊留观患儿转归的危险因素。结果 3岁以下、高热、肢体抖动、血糖大于7.0 mmol/L、白细胞增高的手足口病患儿作为独立的危险因素使患儿转入住院的机会增多(P<0.01或P<0.05)。结论关注高危急诊留观患儿,有助于及时发现手足口病患儿的病情变化,提高其治愈率。存在病情加重危险的患儿,必要时住院进一步治疗。 | 张丽月 Denise Kudirka Colleen Church 肖玉娟 吴闯 孙玉贝 林刚曦 | 2014 | 护理管理杂志2014，14，4： | 7 |
| 5 | Implementation of a Pediatric Emergency Triage System in Xiamen, China显示文摘 | Gang-Xi Lin Yin-Ling Yang Denise Kudirka Colleen Church Collin K K Yong Fiona Reilly Qi-Yi Zeng | 2016 | Chinese Medical Journal2016，，20： | 7 |
| 6 | Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders显示文摘Deep brain stimulation(DBS) is emerging as a pow-erful tool for the alleviation of targeted symptoms in treatment-resistant neuropsychiatric disorders. Despite the expanding use of neuropsychiatric DBS, the mecha-nisms responsible for its effects are only starting to be elucidated. Several modalities such as quantitative elec-troencephalography as well a intraoperative recordings have been utilized to attempt to understand the under-pinnings of this new treatment modality, but functional imaging appears to offer several unique advantages. Functional imaging techniques like positron emission tomography, single photon emission computed tomog-raphy and functional magnetic resonance imaging have been used to examine the effects of focal DBS on activ-ity in a distributed neural network. These investigations are critical for advancing the field of invasive neuro-modulation in a safe and effective manner, particularly in terms of defining the neuroanatomical targets and refining the stimulation protocols. The purpose of this review is to summarize the current functional neuroim-aging findings from neuropsychiatric DBS implantation for three disorders: treatment-resistant depression, obsessive-compulsive disorder, and Tourette syndrome. All of the major targets will be discussed(Nucleus ac-cumbens, anterior limb of internal capsule, subcallosal cingulate, Subthalamic nucleus, Centromedial nucleus of the thalamus-Parafasicular complex, frontal pole, and dorsolateral prefrontal cortex). We will also address some apparent inconsistencies within this literature, and suggest potential future directions for this promis-ing area. | Nolan R Williams Joseph J Taylor Kayla Lamb Colleen A Hanlon E Baron Short Mark S George | 2014 | World Journal of Radiology2014，6，10： | 6 |
| 7 | Depression following a traumatic brain injury:uncovering cytokine dysregulation as a pathogenic mechanism显示文摘A substantial number of individuals have long-lasting adverse effects from a traumatic brain injury(TBI). Depression is one of these long-term complications that influences many aspects of life. Depression can limit the ability to return to work, and even worsen cognitive function and contribute to dementia. The mechanistic cause for the increased depression risk associated with a TBI remains to be defined. As TBI results in chronic neuroinflammation, and priming of glia to a secondary challenge, the inflammatory theory of depression provides a promising framework for investigating the cause of depression following a TBI. Increases in cytokines similar to those seen in depression in the general population are also increased following a TBI. Biomarker levels of cytokines peak within hours-to-days after the injury, yet pro-inflammatory cytokines may still be elevated above physiological levels months-to-years following TBI, which is the time frame in which post-TBI depression can persist. As tumor necrosis factor α and interleukin 1 can signal directly at the neuronal synapse, pathophysiological levels of these cytokines can detrimentally alter neuronal synaptic physiology. The purpose of this review is to outline the current evidence for the inflammatory hypothesis of depression specifically as it relates to depression following a TBI. Moreover, we will illustrate the potential synaptic mechanisms by which tumor necrosis factor α and interleukin 1 could contribute to depression. The association of inflammation with the development of depression is compelling; however, in the context of post-TBI depression, the role of inflammation is understudied. This review attempts to highlight the need to understand and treat the psychological complications of a TBI, potentially by neuroimmune modulation, as the neuropsychiatric disabilities can have a great impact on the rehabilitation from the injury, and overall quality of life. | Colleen N.Bodnar Josh M.Morganti Adam D.Bachstetter | 2018 | Neural Regeneration Research2018，13，10： | 6 |
| 8 | 澳大利亚养老机构关键照护质量指标解析及启示显示文摘澳大利亚的国家养老质量指标项目以压疮、物理约束和非预期体质量下降3个指标为关键照护质量指标内容,本文分别对3个质量指标的定义、所致的不良事件,发生原因等进行解析,为构建适用于我国养老机构的关键照护质量指标提供借鉴。 | 张银华 徐依 陈杨 Colleen Dolye 陈燕 | 2018 | 护理学杂志2018，33，7： | 6 |
| 9 | Subcutaneous Golimumab Induces Clinical Response and Remission in Patients with Moderate-To-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Brian G. Feagan Colleen Marano Hongyan Zhang Richard Strauss Jewel Johanns Omoniyi J. Adedokun Cynthia Guzzo Jean-Frederic Colombel Walter Reinisch Peter R. Gibson Judith Collins Gunnar J?rnerot Toshifumi Hibi Paul Rutgeerts | 2013 | Gastroenterology2013，，： | 6 |
| 10 | Subcutaneous Golimumab Maintains Clinical Response in Patients with Moderate-To-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Brian G. Feagan Colleen Marano Hongyan Zhang Richard Strauss Jewel Johanns Omoniyi J. Adedokun Cynthia Guzzo Jean-Frederic Colombel Walter Reinisch Peter R. Gibson Judith Collins Gunnar J?rnerot Paul Rutgeerts | 2013 | Gastroenterology2013，，： | 5 |
| 11 | Incorporation of Biochar Carbon into Stable Soil Aggregates:The Role of Clay Mineralogy and Other Soil Characteristics显示文摘Aggregation and structure play key roles in water-holding capacity and stability of soils.In this study,the incorporation of carbon(C) from switchgrass biochar into stable aggregate size fractions was assessed in an Aridisol(from Colorado,USA) dominated by 2:1 clays and an Alfisol(from Virginia,USA) containing weathered mixed 1:1 and 2:1 mineralogy,to evaluate the effect of biochar addition on soil characteristics.The biochar was applied at 4 levels,0,25,50,and 100 g kg^(-1),to the soils grown with wheat in a growth chamber experiment.The changes in soil strength and water-holding capacity using water release curves were measured.In the Colorado soil,the proportion of soil occurring in large aggregates decreased,with concomitant increases in small size fractions.No changes in aggregate size fractions occurred in the Virginia soil.In the Colorado soil,C content increased from 3.3 to 16.8 g kg^(-1),whereas in the<53 μm fraction C content increased from 5.7 to 22.6 g kg^(-1) with 100 g kg^(-1)biochar addition.In the Virginia soil,C content within aggregate size fractions increased for each size fraction,except the>2 000 μm fraction.The greatest increase(from 6.2 to 22.0 g kg^(-1)) occurred in the 53–250 μm fraction.The results indicated that C was incorporated into larger aggregates in the Virginia soil,but remained largely unassociated to soil particles in the Colorado soil.Biochar addition had no significant effect on water-holding capacity or strength measurements.Adding biochar to more weathered soils with high native soil organic content may result in greater stabilization of incorporated C and result in less loss because of erosion and transport,compared with the soils dominated by 2:1 clays and low native soil organic content. | Charlene N. KELLY Joseph BENJAMIN Francisco C. CALDERON Maysoon M. MIKHA David W. RUTHERFORD Colleen E. ROSTAD | 2017 | Pedosphere2017，27，4： | 5 |
| 12 | Treating Clostridium difficile Infection With Fecal Microbiota Transplantation显示文摘 | Johan S. Bakken Thomas Borody Lawrence J. Brandt Joel V. Brill Daniel C. Demarco Marc Alaric Franzos Colleen Kelly Alexander Khoruts Thomas Louie Lawrence P. Martinelli Thomas A. Moore George Russell Christina Surawicz | 2011 | Clinical Gastroenterology and Hepatology2011，，12： | 5 |
| 13 | Transient Flare of Ulcerative Colitis After Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection显示文摘 | Lauren M. De Leon James B. Watson Colleen R. Kelly | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 5 |
| 14 | Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis显示文摘 | Jean Frédéric Colombel Paul Rutgeerts Walter Reinisch Dirk Esser Yanxin Wang Yinghua Lang Colleen W. Marano Richard Strauss Bj?rn J. Oddens Brian G. Feagan Stephen B. Hanauer Gary R. Lichtenstein Daniel Present Bruce E. Sands William J. Sandborn | 2011 | Gastroenterology2011，，4： | 3 |
| 15 | Guidance on Preparing an Investigational New Drug Application for Fecal Microbiota Transplantation Studies显示文摘 | Colleen R. Kelly Sachin S. Kunde Alexander Khoruts | 2014 | Clinical Gastroenterology and Hepatology2014，，2： | 2 |
| 16 | Assessing cultural competency skills in gastroenterology fellowship training显示文摘AIM:To assess and teach cultural competency skills at the fellowship training level through the use of objective structured clinical examinations(OSCEs).METHODS:We revised four scenarios to infuse a specific focus on cross-cultural care,and to render them appropriate for gastroenterology fellows.Three are discussed here:(1)Poor Health Literacy;(2)Disclosing/Apologizing for a Complication to a Patient Who Mistrusts the Healthcare System;and(3)Breaking Bad News to a Fatalistic Patient.A fourth case emphasizing shared decision-making will be described elsewhere.Four stations were completed by fellows and observed live by four faculty members,and the fellows’performance was assessed.RESULTS:Eleven fellows from four programs participated in the four OSCE.In the'Poor Health Literacy'case,18%(2/11)of participants recognized that the standardized patient(SP)had below-basic health literacy.None successfully evaluated the SP’s reading skills in a culturally-sensitive manner.In'Disclosing/Apologizing for a Complication',4/11(36%)personally apologized for the complication.1/11 recognized the SP’s mistrust of the medical system.With'Breaking Bad News',27%(3/11)explored the patient’s values to identify her fatalistic beliefs.CONCLUSION:OSCEs can be used to assess deficiencies in culturally-competent care at the fellowship level.OSCEs also afford fellowships the opportunity to inform future training curricula. | Sophie Balzora Benjamin Abiri Xiao-Jing Wang James Mc Keever Michael Poles Sondra Zabar Colleen Gillespie Elizabeth Weinshel | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 17 | Maternal cigarette smoking,metabolic gene polymorphism, and infant birth weight 显示文摘 | Wang XB Barry Z Colleen P | 2002 | JAMA2002，287，： | 2 |
| 18 | Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting显示文摘 | Colleen Gorman Koch Liang Li Andra I. Duncan Tomislav Mihaljevic Delos M. Cosgrove Floyd D. Loop Norman J. Starr Eugene H. Blackstone | 2006 | Critical Care Medicine2006，，6： | 2 |
| 19 | The U-Curve on trial: a longitudinal study of psychological and sociocultural adjustment during Cross-Cultural transition显示文摘 | Colleen Ward Yutaka Okura Antony Kennedy Takahiro Kojima | 1998 | International Journal of Intercultural Relations1998，，3： | 2 |
| 20 | Selective Deactivation of Gibberellins below the Shoot Apex is Critical to Flowering but Not to Stem Elongation of Lolium显示文摘赤霉素(气体) 在 GA1 的合成在植物高度和基因块引起戏剧的增加解释相形见绌 Mendel 的豌豆。为 flowering,是 GA5 重要在长天(LD ) 应答的草, Lolium。当我们这里出现,因为他们被 C-2 hydroxylation 在射击顶下面撤销, GA1 和 GA4 为 flowering 在他们的有效性被限制。相反,因为它的结构的保护, GA5 是有效的。切除植物的射击尖端很快降级[14C ] GA1,[14C ] GA4,并且[14C ] GA20 (>80% 在 6 ? h ) ,然而并非[14C ] GA5。偶然,编码二 2-oxidases 的基因和通常认为的 1617-epoxidase 最就在射击顶下面被表示(< 3 ? 公里) 。进一步击倒不成熟的茎(> 4 ? 公里) ,这些 GA 释放基因的表示被减少,那么允许 GA1 和 GA4 支持接近顶点的茎延伸。随后, GA 降级在花地导致的射击尖端和这些气体衰退能为花的开发变得活跃。稳定 GA4 的结构的变化证实在 florigenicity 和限制 GA 2-hydroxylation 之间的连接(例如 2-hydroxylation 和 C-2 di-methylation ) 。另外,一个 2-oxidase 禁止者(Trinexapac 乙醇) 提高了应用 GA4 的活动,作为做了在 16,17-dihydro 气体或在 C-13 hydroxylation 以后限制 C-16,17 epoxidation。总的来说,就在射击顶下面的 GA1 和 GA4 的释放有效地在 Lolium 限制他们的 florigenicity,相反地,与 GA5,对释放的 C-2 和 C-13 保护允许它的高 florigenicity。思索地,在草的射击顶的 GA 存取的如此的差别可能为把花的正式就职与开花期出现分开是重要的并且能因此在草食动物 predation 的条件下面影响他们的幸存。 | Rod W. King Lewis N. Mander Torben Asp Colleen R MacMillan Cheryl A. Blundell Lloyd T. Evans | 2008 | Molecular Plant2008，1，2： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员