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| 1 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 2 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 3 | Atherosclerotic changes of extracoronary arteries are associated with the extent of coronary atherosclerosis 显示文摘 | JOHN P CHRISTOS M ADRIANA T | 2000 | Am J Cardiol2000，85，： | 1 |
| 4 | ln vivo and in vitro studies on the anticancer activity of Copaifera multijuga Hayne and its fractions显示文摘 | Lima S R M Junior V F V Christo H B | 2003 | Phytotherapy Research2003，17，9： | 1 |
| 5 | Environmental, social and economic information management for the evaluation of sustainability in urban areas: A system of indieators for Thessaloniki, Greece 显示文摘 | Nicolas M Charisios A Christos V | 2010 | Cities2010，，27： | 1 |
| 6 | Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history 显示文摘 | Gob C Finkel M Christos PJ | 2006 | J Eur Acad Dermatol Venereol2006，20，： | 1 |
| 7 | Ankle- Brachial Index as a predictor of the extent of coronary atherosclerosis is and cardiovascular events in patients with coronary artery disease 显示文摘 | Christos M Papamicheal John P | 2000 | Am J Cardiol2000，86，： | 1 |
| 8 | Unravelling the ultrastructure of ascending colon fluids from patients with ulcerative colitis by cryogenic transmission electron microscopy显示文摘 | Anette Müllertz Dimitrios G. Fatouros Maria Vertzoni Christos Reppas | 2013 | J Pharm Pharmacol2013，，10： | 1 |
| 9 | Thomas,Analytical Formulation for the Shielding Effectiveness of Enclosures with Apertures显示文摘 | MARTIN P R TREVOR M B CHRISTOS C | 1998 | IEEE Transaction on Electromagnetic Compatibility1998，40，8： | 1 |
| 10 | Evaluation of alternative calculation methods for determining low-density lipoprotein cholesterol in hemodialysis patients显示文摘 | Eleni TB Christos T Kalientzidou M | 2003 | Clin Biochemi2003，37，2004： | 1 |
| 11 | lnereased mortality among previously apprehended drunken and drugged drivers显示文摘 | Christo SS Phersena AS Grung M | 2002 | Drug Alco- hol Depend2002，68，2： | 1 |
| 12 | Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history 显示文摘 | Goh C Finkel M Christos PJ | 2006 | J Eur Acad Dermatol Venereol2006，20，9： | 1 |
| 13 | A UK-based assessment of hybrid PV and solar-thermal systems for domestic heating and power:System performance显示文摘 | Marí a H Christos N M Klaus H | 2014 | Applied Energy2014，，122： | 1 |
| 14 | Ankle-brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patients with coronary artery disease显示文摘 | Christos M Papamichael John P Lekakis Kimon S Stamatelopoulos Theodoros G Papaioannou Maria K Alevizaki Adriana T Cimponeriu John E Kanakakis Aggeliki Papapanagiotou Anastasios Th Kalofoutis Stamatios F Stamatelopoulos | 2000 | The American Journal of Cardiology2000，，6： | 1 |
| 15 | Acute combined effects of olive oil and wine on pressure wave reflections: another beneficial influence of the Mediterranean diet antioxidants?显示文摘 | Christos M Papamichael Kalliopi N Karatzi Theodore G Papaioannou Emmanouil N Karatzis Paraskevi Katsichti Vasilis Sideris Nikolaos Zakopoulos Antonis Zampelas John P Lekakis | 2008 | Journal of Hypertension2008，，2： | 1 |
| 16 | Predictive factors associated with axillary lymph node metastases in T1 a and T1 b breast carcinomas: analysis in more than 900 patients 显示文摘 | RIVADENEIRA D E SIMMONS R M CHRISTOS P J | 2000 | J Am Coll Surg2000，191，1： | 1 |
| 17 | Ankle-Brachial Index as a predictor of the extent of coronary atherosclerosis and cardiovascular event in patients with coronary artery disease 显示文摘 | Christos M Papamicheal John P | 2000 | Am J Cardiol2000，86，： | 1 |
| 18 | Real time robotic tactile sensor system for the determination of the physical properties of biomaterials 显示文摘 | Sadao O Yoshinobu M Christos E C | 2004 | Sensors and Actuat9rs A : Physical2004，112，23： | 1 |
| 19 | Exercise-mediated adaptations in vascular function and structure:Beneficial effects in coronary artery disease显示文摘Exercise exerts direct effects on the vasculature via the impact of hemodynamic forces on the endothelium,thereby leading to functional and structural adaptations that lower cardiovascular risk.The patterns of blood flow and endothelial shear stress during exercise lead to atheroprotective hemodynamic stimuli on the endothelium and contribute to adaptations in vascular function and structure.The structural adaptations observed in arterial lumen dimensions after prolonged exercise supplant the need for acute functional vasodilatation in case of an increase in endothelial shear stress due to repeated exercise bouts.In contrast,wall thickness is affected by rather systemic factors,such as transmural pressure modulated during exercise by generalized changes in blood pressure.Several mechanisms have been proposed to explain the exercise-induced benefits in patients with coronary artery disease(CAD).They include decreased progression of coronary plaques in CAD,recruitment of collaterals,enhanced blood rheological properties,improvement of vascular smooth muscle cell and endothelial function,and coronary blood flow.This review describes how exercise via alterations in hemodynamic factors influences vascular function and structure which contributes to cardiovascular risk reduction,and highlights which mechanisms are involved in the positive effects of exercise on CAD. | Xenofon M Sakellariou Michail I Papafaklis Eleni M Domouzoglou Christos S Katsouras Lampros K Michalis Katerina K Naka | 2021 | World Journal of Cardiology2021，13，9： | 1 |
| 20 | Mitochondrial dysfunc- tion in osteoarthritis is associated with down-regulation of superoxide dismutase 2 显示文摘 | Christos G Satomi M Thomas von Z | 2013 | Arithritis & Rheumatism2013，65，2： | 1 |
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