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| 1 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 3 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 4 | Continuous internal counterpulsation as a bridge to recovery in acute and chronic heart failure显示文摘Cardiac recovery from cardiogenic shock(CS) and end-stage chronic heart failure(HF) remains anoften insurmountable therapeutic challenge. The counterpulsation technique exerts numerous beneficial effects on systemic hemodynamics and left ventricular mechanoenergetics, rendering it attractive for promoting myocardial recovery in both acute and chronic HF. Although a recent clinical trial has questioned the clinical effectiveness of short-term hemodynamic support with intra-aortic balloon pump(IABP, the main representative of the counterpulsation technique) in CS complicating myocardial infarction, the issue remains open to further investigation. Moreover, preliminary data suggest that long-term IABP support in patients with end-stage HF is safe and may mediate recovery of left- or/and right-sided cardiac function, facilitating long-term weaning from mechanical support or enabling the application of other permanent, life-saving solutions. The potential of long-term counterpulsation could possibly be enhanced by implementation of novel, fully implantable counterpulsation devices. | Christos D Kontogiannis Konstantinos Malliaras Chris J Kapelios Jay W Mason John N Nanas | 2016 | World Journal of Transplantation2016，6，1： | 4 |
| 5 | Chronic nitrogen additions reduce total soil respiration and microbial respiration in temperate forest soils at the Harvard Forest显示文摘 | Richard D Bowden Eric Davidson Kathleen Savage Chris Arabia Paul Steudler | 2004 | Forest Ecology and Management2004，，1： | 2 |
| 6 | Effects of Fenofibrate Treatment on Cardiovascular Disease Risk in 9,795 Individuals With Type 2 Diabetes and Various Components of the Metabolic Syndrome显示文摘 | Scott Russell O’Brien Richard Fulcher Greg Pardy Chris d’Emden Michael Tse Dana Taskinen Marja-Riitta Ehnholm Christian Keech Anthony | 2009 | Diabetes Care2009，，： | 2 |
| 7 | Mapping precipitation in Switzerland with ordinary and indicator Kriging显示文摘 | Peter M Chris D | 1998 | Journal of Geographic Information and Decision Analysis1998，2，2： | 1 |
| 8 | A comparison of the digestibility of a range of lupin and soybean protein products when fed to Atlantic salmon (Salmo salar) or rainbow trout ( Oncorhynchus mykiss) 显示文摘 | Brett D G Chris G C Neil D | 2004 | Aquaculture2004，237，14： | 1 |
| 9 | New insights into magnetic derivatives for structural mapping显示文摘 | Verduzco B Fairhead J D G Chris M | 2004 | The Leading Edge2004，23，： | 1 |
| 10 | The HITRAN molecular spectroscopic database: edition of 2000 including updates through 2001显示文摘 | Rothman L S Barbe A Chris Benner D | 2003 | JQSRT2003，82，： | 1 |
| 11 | The evolution of constructivist learning environments:immersion in distributed virtual worlds显示文摘 | CHRIS D | 1995 | Educational Technology1995，35，5： | 1 |
| 12 | Novel therapeutic approaches for pulmonary fibrosis 显示文摘 | Arnab D Chris JS Rachel CC | 2011 | Br J Pharmacol2011，163，1： | 1 |
| 13 | Large and composition-dependent band gap bowing in InxGa1-x N alloys 显示文摘 | Chris G Van de Walle Chris G McCluskey M D | 1999 | Materials Science and Engineering1999，59，： | 1 |
| 14 | A Compact Optical Flow Cell for Nurse in Aqueous Halide Determination显示文摘 | Chris D G Peter D Christopher P M | | 0，，04： | 1 |
| 15 | Voluntary Disclosure of Segment Information 显示文摘 | Mitchell Jason D Chia Chris W L Loh Andrew S | 1995 | Accounting and Fi nance1995，35，： | 1 |
| 16 | Use of supplementary cementing materials to increase the resistance to chloride ion penetration of concrete cured at elevated temperatures显示文摘 | RACHEL J D CHRIS A F JENNIFER N | 1994 | ACI Materials Journal1994，91，1： | 1 |
| 17 | Minimal gradient encoding for robust estimation of diffusion anisotropy☆显示文摘 | Nikolaos G Papadakis Chris D Murrills Laurance D Hall Christopher L.-H Huang T Adrian Carpenter | 2000 | Magnetic Resonance Imaging2000，，： | 1 |
| 18 | Intuitionistic fuzzy rough sets: At the crossroads of imperfect knowledge 显示文摘 | Chris C Cock M D Kerre E E | 2003 | Expert Systems2003，20，5： | 1 |
| 19 | Methane Line Pa- rameters in H ITRAN 显示文摘 | Brown L R Chris D Benner Champion J P | 2003 | Journal of Quantitative Specmscopy and Radiative Transfer2003，82，： | 1 |
| 20 | Assessment of a mussel as a metal bioindicator of coastal contamination:Relationships between metal bioaccumulation and multiple biomarker responses显示文摘 | Rathishri C Islay D M Chris N G | 2015 | Science of the Total Environment2015，511，： | 1 |
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