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| 1 | Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation显示文摘Dendritic cells (DCs) are the most potent antigen-presen ting cells that play crucial roles in the regulation of immune response. Triptol ide, an active component purified from the medicinal plant Tripterygium wilfor dii Hook F., has been demonstrated to act as a potent immunosuppressive drug c apab le of inhibiting T cell activation and proliferation. However, little is known a bout the effects of triptolide on DCs. The present study shows that triptolide d oes not affect phenotypic differentiation and LPS-induced maturation of murine DCs. But triptolide can dramatically reduce cell recovery by inducing apoptosis of DCs at concentration as low as 10 ng/ml, as demonstrated by phosphatidylserin e exposure, mitochondria potential decrease, and nuclear DNA condensation. Tript olide induces activation of p38 in DCs, which precedes the activation of caspase 3. SB203580, a specific kinase inhibitor for p38, can block the activation of caspase 3 and inhibit the resultant apoptosis of DCs. Our results suggest that t he anti-inflammatory and immunosuppressive activities of triptolide may be due, in part, to its apoptosis-inducing effects on DCs. | LiuQ ChenT ChenH ZhangM LiN LuZ MaP CaoX | 2004 | 第二军医大学学报2004，25，9： | 41 |
| 2 | 雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应显示文摘文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。 | Mengjie Hu Qiang Luo Gulimiran Alitongbieke Shuyi Chong Chenting Xu Lei Xie Xiaohui Chen Duo Zhang Yuqi Zhou Zhaokai Wang Xiaohong Ye Lijun Cai Fang Zhang Huibin Chen Fuquan Jiang Hui Fang Shanjun Yang Jie Liu Maria T.Diaz-Meco Ying Su Hu Zhou Jorge Moscat Xiangzhi Lin 张晓坤 | 2018 | 科学新闻2018，0，4： | 3 |
| 3 | Global spread of dengue virus types: mapping the 70-year history显示文摘 | Jane P. Messina Oliver J. Brady Thomas W. Scott Chenting Zou David M. Pigott Kirsten Duda Samir Bhatt Leah Katzelnick Rosalind E. Howes Katherine E. Battle Cameron P. Simmons Simon I. Hay | 2013 | Trends in Microbiology2013，，： | 2 |
| 4 | Treatment of coking and magnesium ores显示文摘 | ChenT H Huang X M Pan wastewater by using manganese M | 2009 | Journal of Hazardous Materials2009，168，23： | 1 |
| 5 | Screen printed thick self-biased, low-loss, barium hexaferrite films by hot-press sintering 显示文摘 | CHEN Y J SAKAI T K CHENT Y | 2006 | J Appl Phys2006，100，4： | 1 |
| 6 | Effects of wood particle size and mixing ratios of HDPE on the properties of the composites 显示文摘 | Chen H C ChenT Y Hsu C H | 2008 | Polymer Composites2008，29，6： | 1 |
| 7 | Asystematicapproachtoevaluatetheoverallimpactoftheelectrictractiondemandsofahigh-speedrailroadonapowersystem显示文摘 | CHENT H YANG W C HSU YF | 1998 | IEEETransonVehicularTechnology1998，47，4： | 1 |
| 8 | An animal model of MERS pro- duced by infection of rhesus macaques with MERS coro- navirus显示文摘 | Yao Y Bao L Deng W Xu L Li F Lv Q Yu P ChenT Xu Y Zhu H Yuan J Gu S Wei Q Chen H Yuen KY Qin C | 2014 | J Infect Dis2014，209，2： | 1 |
| 9 | The impacts of co- ordinative exercise on executive function in kindergarten chil- dren: an ERP study显示文摘 | CHANG Y K TSAI Y J CHENT T | 2013 | Exp Brain Res2013，225，2： | 1 |
| 10 | Synthesis,acute toxicities and antitumor effects of novel 9-substituted β-carboline derivatives显示文摘 | Cao R Chent Q Hou X | 2004 | Bioorg Med Chem2004，12，： | 1 |
| 11 | Asymmetric strategic alliances: A network view 显示文摘 | CHEN H CHENT | 2002 | Journal of Business Research2002，55，12： | 1 |
| 12 | Development and prospective validation of a clinical index to predict survival in ambulatory, patients for cardiac transplant evaluation 显示文摘 | Aaronson K D Schwartz J S ChenT M | 1997 | Circulation1997，95，12： | 1 |
| 13 | Pyrolysis characteristics and kinetics of sewage sludge by thermogravimetry Fourier transform infrared analysis显示文摘 | SHAO J YAN R CHENT H WANG B LEE D H LIANG D T | 2008 | Energy Fuels2008，22，1： | 1 |
| 14 | Stretch induced programmed myocyte cell death显示文摘 | Chent W Basheng L Kajatura LP | 1995 | J Clin Invest1995，96，6： | 1 |
| 15 | ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins显示文摘 | Wang N Lan D Chent W | 2004 | Proc Natl Acad Sci U S A2004，101，26： | 1 |
| 16 | How do brand communities generate brand relationships? Intermediate mechanisms显示文摘 | Zhimin Zhou Qiyuan Zhang Chenting Su Nan Zhou | 2011 | Journal of Business Research2011，，7： | 1 |
| 17 | Analyststreatmentofnonrecurringitemsinstreetearnings显示文摘 | GuZ ChenT | 2004 | JournalofAccountingandEconomics2004，，12： | 1 |
| 18 | 显示文摘 | FuZJ ZhuLF etal | 2003 | Acta ChimicaSinica (Huaxue Xuebao)2003，61，11： | 1 |
| 19 | An Operator-Based Approach for Modeling Influence Diffusion in Complex Social Networks显示文摘Social media have dramatically changed the mode of information dissemination.Various models and algorithms have been developed to model information diffusion and address the influence maximization problem in complex social networks.However,it appears difficult for state-of-the-art models to interpret complex and reversible real interactive networks.In this paper,we propose a novel influence diffusion model,i.e.,the Operator-Based Model(OBM),by leveraging the advantages offered from the heat diffusion based model and the agent-based model.The OBM improves the performance of simulated dissemination by considering the complex user context in the operator of the heat diffusion based model.The experiment obtains a high similarity of the OBM simulated trend to the real-world diffusion process by use of the dynamic time warping method.Furthermore,a novel influence maximization algorithm,i.e.,the Global Topical Support Greedy algorithm(GTS-Greedy algorithm),is proposed corresponding to the OBM.The experimental results demonstrate its promising performance by comparing it against other classic algorithms. | Chenting Jiang Anthony D’Arienzo Weihua Li Shiqing Wu Quan Bai | 2021 | Journal of Social Computing2021，2，2： | 1 |
| 20 | UsingRefer-entialHierarchicalClusteringAlgorithmtoStudyOffensiveandDefensiveAbilitiesofNBABasket-ballPlayers显示文摘 | ChenMH ChenCT ChenTS etal | 2014 | 电子工程科技国际期刊2014，14，2： | 1 |
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