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| 1 | Towards an evaluation of alcoholic liver cirrhosis and nonalcoholic fatty liver disease patients with hematological scales显示文摘BACKGROUND Seeking potentially novel blood markers of liver fibrosis and steatosis is constantly of crucial importance.Despite a growing number of studies in this field of hepatology,a certain role of hematological indices in the course of liver disorders has not been fully elucidated,yet.AIM To evaluate a diagnostic accuracy of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)and mean platelet volume-to-platelet-ratio(MPR)in the course of alcoholic liver cirrhosis(ALC)and nonalcoholic fatty liver disease(NAFLD).METHODS One hundred forty-two patients with ALC,92 with NAFLD and 68 persons in control group were enrolled in the study.Hematological indices(NLR,PLR and MPR),indirect and direct markers of liver fibrosis(aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index,fibrosis-4,gamma-glutamyl transpeptidase to platelet ratio,procollagen Ⅰ carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,platelet-derived growth factor AB,laminin)were measured in each person.Model for end-stage liver disease(MELD)score in ALC group and NAFLD fibrosis score together with BARD score were calculated in NAFLD patients.Receiver operating characteristic(ROC)curves and area under the curve(AUC)values were applied to assess the sensitivity and specificity of examined markers and to evaluate proposed cut-offs of measured indices in the course of ALC and NAFLD.RESULTS MPR and NLR values in ALC patients were significantly higher in comparison to control group;PLR level was significantly lower.MPR and PLR correlated with assessed indirect and direct markers of liver fibrosis.MPR,NLR and PLR correlated with MELD score.NLR level in NAFLD patients was significantly higher in comparison to controls.MPR correlated with indirect markers of liver fibrosis and NAFLD fibrosis score.AUC values and proposed cut-offs for NLR,PLR and MPR in ALC patients were:0.821(>2.227),0.675(<70.445)and 0.929(>0.048),respectively.AUC values and proposed cut-offs for NLR,PLR and MPR in NAFLD group were:0.725(>2.034),0.528(>97.101)and 0.547(>0.038),respectively.CONCLUSION Hematological markers are inseparably connected with serological indices of liver fibrosis in ALC and NAFLD patients.MPR and NLR turned out to be the most powerful parameters in ALC patients. | Agata Michalak Halina Cichoz-Lach Malgorzata Guz Joanna Kozicka Marek Cybulski Witold Jeleniewicz Andrzej Stepulak | 2020 | World Journal of Gastroenterology2020，26，47： | 6 |
| 2 | Red blood cell distribution width derivatives in alcohol-related liver cirrhosis and metabolic-associated fatty liver disease显示文摘BACKGROUND Looking for undiscovered blood markers of liver fibrosis and steatosis still remains an issue worth exploring.There are still plenty of unresolved issues related to the actual role of hematological indices as potential markers of liver function.AIM To study red blood cell distribution width(RDW),RDW-to-platelet ratio(RPR)and RDW-to-lymphocyte ratio(RLR) in alcohol-related liver cirrhosis(ALC) and metabolic-associated fatty liver disease(MAFLD).METHODS The study group was composed of 302 people:142 patients with ALC and 92 with MAFLD;68 persons were included as controls.RDW,RPR and RLR were measured in each person.Indirect and direct parameters of liver fibrosis were also assessed [aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index(APRI),fibrosis-4(FIB-4),gamma-glutamyl transpeptidase to platelet ratio(GPR),procollagen I carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,plateletderived growth factor AB,laminin].MELD score in ALC patients and nonalcoholic fatty liver disease(NAFLD) fibrosis score together with BARD score were obtained in the MAFLD group.The achieved results were compared to controls.Then a correlation between assessed markers was done.Diagnostic value of each investigated parameter and its suggested cut-off in the research group RESULTS RDW,RPR and RLR values turned out to be significantly higher in ALC and MAFLD groups compared to controls(ALC:P<0.0001;NAFLD:P<0.05,P<0.0001 and P<0.0001,respectively).RPR correlated positively with MELD score(P<0.01) and indirect indices of liver fibrosis(FIB-4 and GPR;P<0.0001) in ALC patients;negative correlations were found between PDGF-AB and both:RDW and RPR(P<0.01 and P<0.0001,respectively).RPR correlated positively with NAFLD fibrosis score and APRI(P<0.0001) in the MAFLD group;a positive relationship was observed between RDW and FIB-4,too(P<0.05).AUC values and suggested cut-offs for RDW,RPR and RLR in ALC patients were:0.912(>14.2%),0.965(>0.075) and 0.914(>8.684),respectively.AUC values and suggested cut-offs for RDW,RPR and RLR in MAFLD patients were:0.606(>12.8%),0.724(>0.047) and 0.691(>6.25),respectively.CONCLUSION RDW with its derivatives appear to be valuable diagnostic markers in patients with ALC.They can also be associated with a deterioration of liver function in this group. | Agata Michalak Małgorzata Guz Joanna Kozicka Marek Cybulski Witold Jeleniewicz Tomasz Lach Halina Cichoż-Lach | 2022 | World Journal of Gastroenterology2022，28，38： | 4 |
| 3 | Noninvasive determination of fetal RHD status by examination of cell-free DNA in maternal plasma显示文摘 | Brojer E Zupanska B Guz K | 2005 | Transfusion2005，45，9： | 1 |
| 4 | Procalcitonin and conventional markers of inflammation in peritoneal dialysis patients and peritonitis显示文摘 | Guz G B.Colak K.Hizel | | 0，，： | 1 |
| 5 | Axisymmetric longitudinal wave propagation in pre-stressed compound circular cylinders 显示文摘 | AKBAROV S D GUZ A N | 2004 | International Journal of Engineering Science2004，42，： | 1 |
| 6 | The physical fundamentals of the uhrasonic nondestructive stress analysis of solids 显示文摘 | Guz A N Makhort F G | 2000 | International Applied Mechanics2000，36，9： | 1 |
| 7 | Retroperitoneal neu- ral sheath tumors: cleveland clinic experience 显示文摘 | Guz BV Wood DP Jr Montie JE | 1989 | J Urol1989，142，14： | 1 |
| 8 | Spectral comparisons of coniferyl and cinnamyl alcohol epoxide derivatives with a purported cis-epoxyconiferyl alcohol isolate 显示文摘 | Nathan R Guz R Frank S | 2000 | Phytochemistry2000，54，8： | 1 |
| 9 | Nestin expression in pancreatic endocrine and exocrine ceils of mice lacking glucagon signaling显示文摘 | Kedees MH Guz Y Vuguin PM | 2007 | Dev Dyn2007，236，4： | 1 |
| 10 | Inhibition of connective tissue growth factor by small interfering ribonucleic acid prevents increase in extracellular matrix molecules in a rodent model of diabetic retinopathy显示文摘 | Winkler JL Kedees MH Guz Y | | 0，，： | 1 |
| 11 | Clinical and radiological aspects of Kartagener' syndrome显示文摘 | Ramotowski R Guz W Zieba E | 2001 | Ann Univ Mariae Curie Sklodowska2001，56，1： | 1 |
| 12 | A robust adaptive beamformer based on worst-case semi-definite programming显示文摘 | YUZL GUZ H ZHOU J J | 2010 | IEEE Transactions on Signal Processing2010，58，11： | 1 |
| 13 | ICI reduction in OFDM sys- tems by using improved sine power pulse 显示文摘 | VOLKAN K GUZ KUCUR O | 2007 | Digital Signal Processing2007，17，6： | 1 |
| 14 | Intravenous iron therapy as a possible risk factor for atherosclerosis in end-stage renal disease显示文摘 | Reis KA Guz G Ozdemir H | 2005 | Int Heart J2005，46，： | 1 |
| 15 | Noninvasive determination of fetal RHD status by examination of cell-free DNA in maternal plasma显示文摘 | Brojer E Zupanska B Guz K | 2005 | Transfusion2005，45，9： | 1 |
| 16 | Children's understanding of the distinction between real and apparent emotion显示文摘 | HARRIS P L DONNELLY K GUZ G R PITT-WATSON R | | 0，，： | 1 |
| 17 | Detrimental effect of protracted hyperglycaemia on beta-cell neogenesis in a mouse murine model of diabetes显示文摘 | Guz Y Torres A Teitelman G | 2002 | Diabetologia2002，45，： | 1 |
| 18 | Multi-view semi- supervised learning for dialog act segmentation of speech 显示文摘 | GUZ U CUENDET S HAKKANI-TUR D | 2010 | IEEE Transactions on Audio Speech and Language Processing2010，18，2： | 1 |
| 19 | Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrineprogenitors during ontogeny 显示文摘 | GUZ Y MONTMINY MR STEIN R | 1995 | Development1995，121，1： | 1 |
| 20 | Clinical and morphologi- cal aspects of gray matter heterotopia type developmental malformations 显示文摘 | Zajac-Mnich M Kostkiewicz A Guz W | 2014 | Pol J Radiol2014，79，： | 1 |
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