| 1 | Effect of endotoxin on portal hemodynamic in rats显示文摘AIM: To study the effects of endotoxin on portalhemodynamic of normal and noncirrhotic portal hypertensiverats.METHODS: Normal rats were intraperitonealy injected with 0.1,0.25, 0.5, 1.0, 2.0, 4.0 mg@kg-1 of lipopolysaccharide( LPS ) respectively, portal vein ligation ( PVL ) andintrahepatic portal occlusion (IPO) rats as well as sham-operated rats were treated with an intraperitoneal injection of1.0 mg@kg-1 of LPS, the portal vein pressure(PVP), portalvenous flow(PVF), inferior vena cava pressure(IVCP) andportal vein resistance (PVR) were detected 4 hours afterinjection.RESULTS: PVF of the 5 groups of rats acceptingintraperitoneal injection of LPS were increased from 14.0 to18.0, 22.2, 266.2, 34.8, 39.66, 38.8 mL@min-1 4 hours afterinjection of LPS ( P < 0. 01 ). PVP of the 4 groups of ratsaccepting more than 0.1 mg/kg@ b. w of LPS was increasedfrom 1.04 to1.25, 1.50, 1.80, 1.95, 2.05 kPa(P<0.01). Theincrements of PVF and PVP were in a dose-dependentmanner of LPS. PVR of the 5 groups of rats was decreasedfrom 51 to 42,44,48,45,44,47 kPa@min@ L-1 ( P< 0.05) and nodosedependent manner wes observed. PVF of PVL, IPOand sham-operated rats increased from 22.66 to 32.8, 22.0 to28.0, 14.0 to 34.8 mL@min1 ( P< 0.01), and PVP increasedfrom 1.86 to 2.24, 1.74 to 1.95, 1.04 to 1.80 kPa(P<0.01),PVR decreased from 71 to61, 67 to61, 52 to 44 kPa@min@ L-1after intraperitoneal injection of 1 mg@ kg-1 of LPS. Theincrements of PVF and PVP of PVL and IPO rats weresignificantly less than the sham-operated rats ( P < 0. 01 ),There wes no significant difference between the amounts ofPVR decreased in the two groups of PHT model rats andsham-operated rats( P> 0.05) after intraperitoneal injection 1mg@kg1 of LPS.CONCLUSION: Endotoxin could prompt portal hypertensionof the normal and noncirrhotic portal hypertensive rats byincreasing portal blood flow mainly. | BiXJ ChenMH | 2002 | World Journal of Gastroenterology2002，8，3： | 9 |
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