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| 1 | Hypoxia-inducible factor-lαand semaphorin4D genes involved with tumor-associated macrophage-induced metastatic behavior and clinical significance in colon cancer显示文摘 | Mu Linjun Wang Jinshen Chen Yuezhi Li Leping Guo Xiaobo Zheng Sheng Jing Changqing | 2014 | Chinese Medical Journal2014，，20： | 15 |
| 2 | Comparison of sentinel lymph node detection performances using blue dye in conjunction with indocyanine green or radioisotope in breast cancer patients: a prospective singlecenter randomized study显示文摘Objective:This randomized study aimed to compare the clinical efficacy between the novel dual tracer composed of indocyanine green(ICG)and blue dye(BD)and the conventional dual tracer composed of radioisotope and BD for sentinel lymph node(SLN)mapping in patients with breast cancer.Methods:This study enrolled 471 clinically lymph node-negative patients with primary breast cancer.All patients underwent mastectomy,and those undergoing sentinel lymph node biopsy(SLNB)were randomized to receive blue dye plus radioisotope(RB group)or BD plus ICG(IB group).The detection performances on SLN identification rate,positive SLN counts,detection sensitivity,and false-negative rate were compared between the two groups.Results:In the IB group,97%(194/200)of the patients who underwent the ICG and BD dual tracer injection showed fluorescentpositive lymphatic vessels within 2–5 min.The identification rate of SLNs was comparable between the IB group(99.0%,198/200)and the RB group(99.6%,270/271)(P=0.79).No significant differences were observed in the identification rate of metastatic SLNs(22.5%vs.22.9%,P>0.05,RB group vs.IB group,the same below),positive SLN counts(3.72±2.28 vs.3.91±2.13,P>0.05),positive metastatic SLN counts(0.38±0.84 vs.0.34±0.78,P>0.05),SLNB detection sensitivity(94.4%vs.92.5%,P>0.05),or false-negative rate(5.6%vs.7.5%,P>0.05)between the two groups.Conclusions:ICG can be used as a promising alternative tracer for radioisotope in SLN mapping,and when it is combined with BD in lymphangiography,it offers comparable detection sensitivity compared to the conventional lymphatic mapping strategies that are widely used in clinical practice. | Long Yuan Xiaowei Qi Yi Zhang Xinhua Yang Fan Zhang Linjun Fan Li Chen Kongyong Zhang Ling Zhong Yanling Li Sijie Gan Wenying Fu Jun Jiang | 2018 | Cancer Biology & Medicine2018，15，4： | 9 |
| 3 | Active/passive Q-switching operation of 2 μm Tm,Ho:YAP laser with an acousto-optical Q-switch/MoS_2 saturable absorber mirror显示文摘The active/passive Q-switching operation of a 2 μm a-cut Tm,Ho:YAP laser was experimentally demonstrated with an acousto-optical Q–switch∕MoS_2 saturable absorber mirror. The active Q-switch laser was operated for the first time, to the best of our knowledge, with an average output power of 12.3 W and a maximum pulse energy of 10.3 mJ. The passive Q-switch laser was also the first acquired with an average output power of 3.3 W and per pulse energy of 23.31 μJ, and the beam quality factors of M_x^2 = 1.06 and M_y^2 = 1.06 were measured at the average output power of 2 W. | LINJUN LI XINING YANG LONG ZHOU WENQIANG XIE YUNLONG WANG YINGJIE SHEN YUQIANG YANG WENLONG YANG WEI WANG ZHIWEI LV XIAOMING DUAN MINGHUA CHEN | 2018 | Photonics Research2018，6，6： | 5 |
| 4 | Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish ( Danio rerio )显示文摘 | Yuanxiang Jin Xiangxiang Zhang Linjun Shu Lifang Chen Liwei Sun Haifeng Qian Weiping Liu Zhengwei Fu | 2009 | Chemosphere2009，，7： | 2 |
| 5 | Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration显示文摘Inflammatory responses of nucleus pulposus(NP)can induce imbalanced anabolism and catabolism of extracellular matrix,and the cytosolic dsDNA accumulation and STING-NF-κB pathway activation found in NP inflammation are considered as fairly important cause of intervertebral disc(IVD)degeneration.Herein,we constructed a siSTING delivery hydrogel of aldehyde hyaluronic acid(HA-CHO)and poly(amidoamine)PAMAM/siRNA complex to intervene the abnormal STING signal for IVD degeneration treatment,where the formation of dynamic Schiff base bonds in the system(siSTING@HPgel)was able to overcome the shortcomings such as low cellular uptake,short half-life,and rapid degradation of siRNA-based strategy.PAMAM not only formed complexes with siRNA to promote siRNA transfection,but also served as dynamic crosslinker to construct hydrogel,and the injectable and self-healing hydrogel efficiently and steadily silenced STING expression in NP cells.Finally,the siSTING@HPgel significantly eased IVD inflammation and slowed IVD degeneration by prolonging STING knockdown in puncture-induced IVD degeneration rat model,revealing that STING pathway was a therapeutic target for IVD degeneration and such novel hydrogel had great potential for being applied to many other diseases for gene delivery. | Jiaxin Chen Haifeng Zhu Yutao Zhu Chenchen Zhao Shengyu Wang Yixin Zheng Ziang Xie Yang Jin Honghai Song Linjun Yang Jin Zhang Jiayong Dai Zhijun Hu Huaiyu Wang | 2022 | Bioactive Materials2022，7，3： | 2 |
| 6 | Trends in Fhysician Diagnosed Gout and Gout Therapies in the US: Results from the National Ambulatory Health Care Surveys 1993 to 2009显示文摘 | Eswar Krishnan Linjun Chen | 2013 | Arthritis Res Ther2013，15，6： | 1 |
| 7 | Advances in graphene oxide membranes for water treatment显示文摘Graphene oxide(GO),a derivative of graphene,is a novel carbon material that has attracted a lot of attention in the field of membrane materials as its ability to achieve layer-by-layer stacking and the formation of nanochannels between the lamellae makes it excellent for selective separation of substances.In this paper,the separation mechanism of the GO membrane is summarized.According to the different separation substances,the separation mechanism of graphene oxide membrane is reviewed from two aspects of metal ions and organic pollutants.Next,the preparation methods of graphene oxide membranes is introduced,such as spin-coating,vacuum filtration,dip-coating,spraying,and layer-by-layer self-assembly,followed by a review on the structural regulation of GO.Finally,this paper concludes with an overview of the potential development prospects and challenges of GO membranes. | Fengchun Jia Xiao Xiao Ardo Nashalian Sophin Shen Liu Yang Zhenyang Han Huaijiao Qu Tianmei Wang Zhi Ye Zhijun Zhu Linjun Huang Yanxin Wang Jianguo Tang Jun Chen | 2022 | Nano Research2022，15，7： | 1 |
| 8 | Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish ( Danio rerio )显示文摘 | Yuanxiang Jin Xiangxiang Zhang Linjun Shu Lifang Chen Liwei Sun Haifeng Qian Weiping Liu Zhengwei Fu | 2009 | Chemosphere2009，，7： | 1 |
| 9 | FGF8-mediated signaling regulates tooth developmental pace during odontogenesis显示文摘The developing human and mouse teeth constitute an ideal model system to study the regulatory mechanism underlying organ growth control since their teeth share highly conserved and well-characterized developmental processes, and their developmental tempo varies notably. In the current study, we manipulated heterogenous recombination between human and mouse dental tissues and demonstrated that the dental mesenchyme dominates the tooth developmental tempo and FGF8 could be a critical player during this developmental process. Forced activation of FGF8 signaling in the dental mesenchyme of mice promoted cell proliferation, prevented cell apoptosis via p38 and perhaps PI3 K-Akt intracellular signaling,and impelled the transition of the cell cycle from G1-to S-phase in the tooth germ, resulting in the slowdown of the tooth developmental pace. Our results provide compelling evidence that extrinsic signals can profoundly affect tooth developmental tempo, and the dental mesenchymal FGF8 could be a pivotal factor in controlling the developmental pace in a non-cell-autonomous manner during mammalian odontogenesis. | Chensheng Lin Ningsheng Ruan Linjun Li Yibin Chen Xiaoxiao Hu YiPing Chen Xuefeng Hu Yanding Zhang | 2022 | Journal of Genetics and Genomics2022，49，1： | 1 |
| 10 | Transforming growth factor-β1 polymorphisms and breast cancer risk: a meta-analysis based on 27 case–control studies显示文摘 | Xiaowei Qi Fan Zhang Xinhua Yang Linjun Fan Yi Zhang Li Chen Yan Zhou Xianchun Chen Ling Zhong Jun Jiang | 2010 | Breast Cancer Research and Treatment2010，，1： | 1 |
| 11 | Loss of SOCS3 expression is associated with an increased risk of recurrent disease in breast carcinoma显示文摘 | Mingzhen Ying Dawei Li Linjun Yang Mei Wang Ning Wang Ying Chen Miaoxia He Yajie Wang | 2010 | Journal of Cancer Research and Clinical Oncology2010，，10： | 1 |
| 12 | Effects of Ti additive on the structure and electrochemical performance of LiMnPO 4 cathode material显示文摘 | Laifen Qin Yonggao Xia Hailiang Cao Linjun Luo Qian Zhang Lipeng Chen Zhaoping Liu | 2014 | Electrochimica Acta2014，，： | 1 |
| 13 | Controlling exciton-exciton annihilation in WSe_(2) bilayers via interlayer twist显示文摘The twist angle between two van der Waals coupled monolayers has emerged as a new and powerful degree of freedom for engineering physical properties of semiconductor homo-and hetero-bilayers.While the interlayer twist has shown prominent effect on electronic and optical properties of transition metal dichalcogenide(TMD)bilayers,it remains unclear how it could be used to manipulate the exciton dynamics,especially exciton-exciton annihilation(EEA)process which is the dominant energy loss channel in TMDs under moderate to high exciton density due to strong Coulomb interaction.Herein,we show that the twist angle in TMD bilayers can act as an effective knob to control the EEA process.Specifically,EEA rate constant increases from 1° twisted WSe_(2) bilayers(0.026 cm^(2)/s)by more than twice to 32° twisted bilayers(0.053 cm2/s)and then drops again in 60° twisted bilayers(0.019 cm^(2)/s).This twist-angle dependence can be attributed to the energy difference between indirect and direct excitons arising from the interlayer interaction.Our work opens up the possibility of artificially managing the exciton dynamics in TMD materials for optoelectronic applications via interlayer twist angle. | Yuzhong Chen Bichuan Cao Cheng Sun Zedong Wang Hongzhi Zhou Linjun Wang Haiming Zhu | 2022 | Nano Research2022，15，5： | 1 |
| 14 | Emergy evaluations of three aquaculture systems on wetlands surrounding the Pearl River Estuary, China显示文摘 | Linjun Li Hongfang Lu Hai Ren Wenling Kang Feipeng Chen | 2010 | Ecological Indicators2010，，2： | 1 |
| 15 | Exploiting flash memory characteristics to improve performance of RAIS storage systems显示文摘Redundant array of independent SSDs (RAIS) is generally based on the traditional RAID design and implementation. The random small write problem is a serious challenge of RAIS. Random small writes in parity-based RAIS systems generate significantly more pre-reads and writes which can degrade RAIS performance and shorten SSD lifetime. In order to overcome the well-known write-penalty problem in the parity-based RAID5 storage systems, several logging techniques such as Parity Logging and Data Logging have been put forward. However, these techniques are originally based on mechanical characteristics of the HDDs, which ignore the properties of the flash memory. In this article, we firstly propose RAISL, a flash-aware logging method that improves the small write performance of RAIS storage systems. RAISL writes new data instead of new data and pre-read data to the log SSD by making full use of the invalid pages on the SSD of RAIS. RAISL does not need to perform the pre-read operations so that the original characteristics of workloads are kept. Secondly, we propose AGCRL on the basis of RAISL to further boost performance. AGCRL combines RAISL with access characteristic to guide read and write cost regulation to improve the performance of RAIS storage systems. Our experiments demonstrate that the RAISL significantly improves write performance and AGCRL improves both of write performance and read performance. AGCRL on average outperforms RAIS5 and RAISL by 39.15% and 16.59% respectively. | Linjun MEI Dan FENG Lingfang ZENG Jianxi CHEN Jingning LIU | 2019 | Frontiers of Computer Science2019，13，5： | 0 |
| 16 | SET1A催化YAP甲基化修饰调控YAP细胞核转运和促进肿瘤发生显示文摘文章简介YAP作为Hippo信号通路主要效应因子之一,在Hippo通路受抑的条件下,从细胞质转运至细胞核调控基因表达和促进肿瘤发生。虽然YAP锚定在细胞质中的调控机制已经被广泛研究,但是YAP激活后入核在细胞核中持续积累的分子机制并不十分清楚。 | 方兰 滕鸿琦 王益林 廖光红 Linjun Weng Yaxu Li Xinbo Wang Jiali Jin Chenchen Jiao Lei Chen Xiaoping Peng Jiayu Chen Yongzhi Yang Houqin Fang Dongyan Han Cheng Li Xueling Jin Shihao Zhang Zhongchen Liu Min Liu Qing Wei Lujian Liao Xin Ge Bin Zhao Dawang Zhou HuanLong Qin Jun Zhou 王平 | 2019 | 科学新闻2019，0，2： | 0 |
| 17 | 智能胶囊米仓设计显示文摘这款胶囊米仓针对粮食的储存与食品浪费问题进行设计,能够延长谷物的保质期,并通过可量化米仓、轻量化包装的新方式来储存粮食。可量化的智能米仓,让粮食储存更加方便,同时让粮食的存取更加量化,更加精确,避免浪费。胶囊米仓设计有透明的胶囊箱,可以让用户直观地看到内部,从而增强使用体验。与传统的粮食储存方法相比,胶囊米仓提供了更长的保质期,通过改进储存方式. | Chen Tongtong Han Luyao Li Yanda Ling Junjie Liu Weirui Liu Yi Ruan Ziqing Yu Linjun Yuan Yang | 2023 | 工业设计2023，，11： | 0 |
| 18 | An estimation framework of regional rooftop photovoltaic potential based on satellite remote sensing images显示文摘This paper proposes a comprehensive framework for estimating the regional rooftop photovoltaic(PV)potential.The required rooftop information is extracted from Gao Fen-7 satellite images.In particular,the rooftop area is obtained using a semantic segmentation network.The azimuth and inclination angles are calculated based on the digital surface model.In addition,to improve the accuracy of the economic evaluation,buildings are divided into commercial and industrial buildings and residential buildings.Based on the difference in the roof inclination,the rooftops can be divided into flat roofs,on which the PV panels are installed with the optimal inclination angle,and sloped rooftops,on which the PV panels are installed in a lay-flat manner.The solar irradiation on the plane-of-array is calculated using the isotropic sky translocation model.Then,the available installed capacity and generation potential of the rooftop PV is obtained.Finally,the net present value,dynamic payback period,and internal rate of return are used to evaluate the economic efficiency of the rooftop PV project.The proposed framework is applied in the Da Xing district of Beijing,China,with a total area of 546.84 km^(2).The results show that the rooftop area and available installed capacity of PV are 25.63 km^(2)and 1487.45 MWp,respectively.The annual rooftop PV generation potential is 2832.23 GWh,with significant economic returns. | Boyu Chen Yanbo Che Jingkai Wang Hongfeng Li Linjun Yu Dacheng Wang | 2022 | Global Energy Interconnection2022，5，3： | 0 |
| 19 | Preparation and Application of Bauxite-based Sintered Mullite Homogenized Grog in Ladle Castable显示文摘Preparation of bauxite-based sintered mullite homogenized grog was introduced and its application in ladle castable was studied.Two kinds of bauxite-based sintered mullite homogenized grogs were used,named as GA and GB,respectively.The results show that bauxitebased sintered homogenized grog with uniform components,stable microstructure and mullite as main crystal phase can be prepared using joint process of three-step homogenization,automatic component batching,wet cogrinding,high-temperature calcinations.It also indicates that carbon steel ladle castables with GA or composite aggregate of GA and GB as main materials have the same excellent general performance indicators,great erosion resistance,anti-strip performance and longer service life in field applications,and compared with castables with single aggregate of GA,the castables with aggregate of GA and GB as main materials had higher cost performance because of lower bulk density of GB. | AN Jiancheng GAO Changhe WANG Yali CHEN Chaoqun WANG Linjun | 2016 | China's Refractories2016，25，4： | 0 |
| 20 | Progress in Research on the Role of Angiomotins in Cancer显示文摘Cancer is a major public health problem worldwide and its overall morbidity and mortality have been increasing every year.The growth,invasion and metastasis of cancer are vital traits of malignancy causing extreme difficulties in therapeutic management.These behavioral characteristics of cancer are closely related to tumor angiogenesis.The argument was put forward that tumorigenesis depended on the formation of new blood vessels,which gained insight into a promising treatment strategy for cancer based on the inhibition of tumor angiogenesis.To date,many new therapeutic strategies targeting tumor vessels are universally accepted and become a hotspot in oncology research.Angiomotin(Amot),encoded by Amot gene,is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta.During the formation of new blood vessels,Amot may play an inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors.In this review,we summarized the structure and function of Amot,and its mechanism and research progress in cancer. | XU Fei LI Wenhui CHEN Linjun FANG Wenjuan | 2020 | Wuhan University Journal of Natural Sciences2020，25，5： | 0 |
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