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| 1 | Hypoxia-inducible factor-lαand semaphorin4D genes involved with tumor-associated macrophage-induced metastatic behavior and clinical significance in colon cancer显示文摘 | Mu Linjun Wang Jinshen Chen Yuezhi Li Leping Guo Xiaobo Zheng Sheng Jing Changqing | 2014 | Chinese Medical Journal2014，，20： | 15 |
| 2 | Regionalization based on spatial and seasonal variation in ground-level ozone concentrations across China显示文摘Owing to the vast territory of China and strong regional characteristic of ozone pollution,it's desirable for policy makers to have a targeted and prioritized regulation and ozone pollution control strategy in China based on scientific evidences. It's important to assess its current pollution status as well as spatial and temporal variation patterns across China.Recent advances of national monitoring networks provide an opportunity to insight the actions of ozone pollution. Here, we present rotated empirical orthogonal function(REOF)analysis that was used on studying the spatiotemporal characteristics of daily ozone concentrations. Based on results of REOF analysis in pollution seasons for 3 years' observations, twelve regions with clear patterns were identified in China. The patterns of temporal variation of ozone in each region were separated well and different from each other, reflecting local meteorological, photochemical or pollution features. A rising trend in annual averaged Eight-hour Average Ozone Concentrations(O_3-8 hr) from 2014 to 2016 was observed for all regions, except for the Tibetan Plateau. The mean values of annual and 90 percentile concentrations for all 338 cities were 82.6 ± 14.6 and 133.9 ± 25.8 μg/m^3,respectively, in 2015. The regionalization results of ozone were found to be influenced greatly by terrain features, indicating significant terrain and landform effects on ozone spatial correlations. Among 12 regions, North China Plain, Huanghuai Plain, Central Yangtze River Plain, Pearl River Delta and Sichuan Basin were realized as priority regions for mitigation strategies, due to their higher ozone concentrations and dense population. | Linjun Cheng Shuai Wang Zhengyu Gong Hong Li Qi Yang Yeyao Wang | 2018 | Journal of Environmental Sciences2018，30，5： | 14 |
| 3 | Carbonatites in China:A review for genesis and mineralization显示文摘Carbonatites 是通常与象 REE, Cu,和 P 那样的经济地珍贵的物质的累积有关。在到联系硅酸盐岩石的 carbonatites 和他们的关系的起源上的争论是进行中的大约 45 年了。全球,岩石表示特性地比沉积碳酸盐岩石在 Ba, Sr 和 REE 显示更多的 geochemical 丰富。然而,因为第二等的矿物质效果, carbonatites geochemical 特征被争论。从在在中国的 Qinling, Panxi 区域,和 Bayan Obo 的 carbonatites 的形成岩石的碳酸盐显示出从 LREE 丰富到扁平的模式的 REE 分发模式。他们被超过 10 比第二等的碳酸盐的高预定的一个 Sr 内容描绘。从 Bayan Obo H8 白云石云石的纹理粗糙、有细密纹理的白云石也显示出类似的高 Sr 丰富,显示他们具有火的起源。在中国 carbonatites 的一些碳酸盐显示出 REE (特别 HREE ) 整个岩石的类似于那些的内容和分布模式。这些恼人的 carbonatites 显示相对 high-Si 降低在磅和红外之间的铂组元素和更强壮的分别挤出的 carbonatite。这显示很恼人的 carbonatites 可以是碳酸盐堆积。在 Panxi 区域的 Maoniuping 和 Daluxiang 是大 REE 沉积物。热水的荧石矿石静脉发生在 carbonatite 身体外面并且是在 wallrock 的 emplaced 正长岩。在 Maoniuping 的荧石有类似于 carbonatite 的 Sr 和 Nd 同位素。Daluxiang 荧石在 Maoniuping 显示出与那些不同的 Sr 和 REE 作文。差别被 carbonatites 和形成岩石的碳酸盐反映,显示那个 REE 矿化作用与 carbonatites 有关。碳酸盐矿物质的 cumulate 进程从 LREE 由于为在碳酸盐和 carbonatite 之间的 REE 的系数融化的低分区和增加在 volatiles 和 LREE 使 fractionated 液体富有到 HREE。导出 carbonatite 的液体与 wallrock 交往了形成 REE 矿石静脉。发生在 Bayan Obo orebodies 附近的 carbonatite 女同性恋的数量可以支持一样的矿化作用模型,即液体从 carbonatite 女同性恋演变,这与 H8 白云石大理石反应了,并且这样纹理粗糙、有细密纹理的白云石的不同 REE 和同位素作文可能与反应过程有关。 | Cheng Xu Linjun Wang Wenlei Song Min Wu | 2010 | Geoscience Frontiers2010，1，1： | 10 |
| 4 | Active/passive Q-switching operation of 2 μm Tm,Ho:YAP laser with an acousto-optical Q-switch/MoS_2 saturable absorber mirror显示文摘The active/passive Q-switching operation of a 2 μm a-cut Tm,Ho:YAP laser was experimentally demonstrated with an acousto-optical Q–switch∕MoS_2 saturable absorber mirror. The active Q-switch laser was operated for the first time, to the best of our knowledge, with an average output power of 12.3 W and a maximum pulse energy of 10.3 mJ. The passive Q-switch laser was also the first acquired with an average output power of 3.3 W and per pulse energy of 23.31 μJ, and the beam quality factors of M_x^2 = 1.06 and M_y^2 = 1.06 were measured at the average output power of 2 W. | LINJUN LI XINING YANG LONG ZHOU WENQIANG XIE YUNLONG WANG YINGJIE SHEN YUQIANG YANG WENLONG YANG WEI WANG ZHIWEI LV XIAOMING DUAN MINGHUA CHEN | 2018 | Photonics Research2018，6，6： | 5 |
| 5 | Propane dehydrogenation catalyzed by in-situ partially reduced zinc cations confined in zeolites显示文摘Propane dehydrogenation(PDH), employing Pt-or Cr-based catalysts, represents an emerging industrial route for propylene production. Due to the scarcity of platinum and the toxicity of chromium, alternative PDH catalysts are being pursued. Herein, we report the construction of Zn-containing zeolite catalysts,namely Zn@S-1, for PDH reaction. Well-isolated zinc cations are successfully trapped and stabilized by the Si-OH groups in S-1 zeolites via in-situ hydrothermal synthesis. The as-prepared Zn@S-1 catalysts exhibit good dehydrogenation activity, high propylene selectivity, and regeneration capability in PDH reaction under employed conditions. The in-situ partial reduction of zinc species is observed and the partially reduced zinc cations are definitely identified as the active sites for PDH reaction. | Linjun Xie Rui Wang Yuchao Chai Xuefei Weng Naijia Guan Landong Li | 2021 | Journal of Energy Chemistry2021，30，12： | 4 |
| 6 | Evaluation of probiotic yoghurt by the mixed culture with Lactobacillus plantarum A3显示文摘Lactic acid bacteria(LAB)fermentation is the simplest and safest way of food preservation,and the use of probiotics in yoghurt could provide dairy products with unique flavors,textures and health benefits.In this study,Lactobacillus bulgaricus,Streptococcus thermophilus,L.reuteri DSMZ 8533 and the potential probiotic strain L.plantarum A3 were used for the milk fermentation.Results found the texture properties such as hardness,consistency,and viscosity of the yoghurt were enhanced in the mixed culture condition.Furthermore,components like amino acid(leucine),vanilla(vanillin),C;(unsaturated fatty acids)were also accumulated in L.plantarum A3 fermented yoghut,which leads to the significant sensory profiling difference compared with the former plain yoghurt.All these results proved L.plantarum A3 is a potential probiotic stom winch could enhance the sensory and nutrition profiling of the fermented milk.Future work still needs to be done on the synergistic interaction between the traditional strains and the probiotics during the fermentation process. | Fengxuan Lang Jianzhu Wen Zhen Wu Daodong Pan Linjun Wang | 2022 | Food Science and Human Wellness2022，11，2： | 3 |
| 7 | Exosomes Released from Rabies Virus-Infected Cells May be Involved in the Infection Process显示文摘Exosomes are cell-derived vesicles that are secreted by many eukaryotic cells. It has recently attracted attention as vehicles of intercellular communication. Virus-infected cells release exosomes, which contain viral proteins, RNA, and pathogenic molecules. However, the role of exosomes in virus infection process remains unclear and needs to be further investigated.In this study, we aimed to evaluate the effects of exosomes on rabies virus infection. OptiPrep^(TM) density gradient centrifugation was used to isolate exosomes from rabies virus-infected cell culture supernatants. A rabies virus G protein enzyme-linked immunosorbent assay and acetylcholinesterase activity assays were performed to verify the centrifugation fractions. Exosomes were then characterized using transmission electron microscopy and Western blotting. Our results showed that rabies virus infection increased the release of exosomes. Treatment with GW4869 and si-Rab27 a, two exosomal secretion inhibitors, inhibited exosome release. Furthermore, the inhibitors reduced the levels of extracellular and intracellular viral RNA. These data indicated that exosomes may participate in the viral infection process. Moreover, our results establish a basis for future research into the roles of exosomes in rabies virus infection and as potential targets for developing new antiviral strategies. | Jingyu Wang Fan Wu Chuntian Liu Wenwen Dai Yawei Teng Weiheng Su Wei Kong Feng Gao Linjun Cai Ali Hou Chunlai Jiang | 2019 | Virologica Sinica2019，34，1： | 3 |
| 8 | CO2 capture over molecular basket sorbents:Effects of SiO2 supports and PEG additive显示文摘The objective of this work is to study the influences of silica supports and PEG additive on the sorption performance of molecular basket sorbent(MBS) for CO_2 capture consisting of polyethylenimine and one of the following supports: SBA-15(2-D structure), TUD-1(3-D sponge-like structure) and fumed silica HS-5(3-D disordered structure). Effects of the supports regarding pore structures and pore properties, the PEI loading amount as well as the sorption temperature were examined. Furthermore, polyethylene glycol(PEG) was introduced as an additive into the sorbents and its effect was investigated at different PEI loadings and sorption temperatures. The results suggest that the pore properties of MBS(after PEI loading) play a more important role in the CO_2 sorption capacity, rather than those of the supports alone.MBS with 3D pore structure exhibits higher CO_2 sorption capacity and amine efficiency than those with 2D-structured support. Among the sorbents studied, fumed silica(HS-5) based MBS showed the highest CO_2 sorption capacity in the temperature range of 30-95 °C, probably due to its unique interstitial pores formed by the aggregation of polymer-loaded SiO_2 particles. It was found that the temperature dependence is directly related to the PEI surface coverage layers. The more PEI surface coverage layers, the higher diffusion barrier for CO_2 and the stronger temperature dependence of CO_2 capacity. 3D MBS exceeds 2D MBS at the same PEI coverage layers due to lower diffusion barrier. Adding PEG can significantly enhance the CO_2 sorption capacity and improve amine efficiency of all MBS, most likely by alleviating the diffusion barrier within PEI bulk layers through the inter-molecular interaction between PEI and PEG. | Lin Zhang Xiaoxing Wang Mamoru Fujii Linjun Yang Chunshan Song | 2017 | Journal of Energy Chemistry2017，26，5： | 3 |
| 9 | Molecular dynamics simulation of chip formation mechanism in single-crystal nickel nanomachining显示文摘Nanometric machining simulations of single-crystal nickel were performed using molecular dynamics.The atomic displacement vector method was applied to study the relationship between defect displacement vectors and the crystal slip system during different deformation stages as well as the displacement trend characteristics of workpiece atoms under different deformations.The arrangement characteristics of atoms in the machining region,relative density of atoms at different machining zones,and proportion of different atoms were investigated in detail.In addition,the atom shunt phenomenon was observed by studying the displacement trend of the atoms adjacent to the machining tool,and a method for determining the location of the shunt point was determined.Moreover,direct evidence of crystal transition caused by temperature was obtained.The effects of machining depth on workpiece damage,surface flatness,and workpiece temperature were investigated.With increasing machining depth,the chip gradually changed from spherical to strip-shaped,the damage depth of workpiece gradually increased,but the atomic arrangement of the machined surface became neater.Simultaneously,the dislocation reaction of subsurface defects was studied,and the rationality of the reaction was analyzed using an energy criterion.Furthermore,the overall temperature of the workpiece increased,but the temperature of the chip part gradually decreased. | ZHU ZongXiao PENG Bin FENG RuiCheng WANG LinJun JIAO Shi DONG Yun | 2019 | Science China(Technological Sciences)2019，62，11： | 2 |
| 10 | APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells显示文摘APOBEC3 protein families, a DNA cytidine deaminase, were up-regulated in multiple tumors. However, the relationship between Hepatocellular carcinoma(HCC) and APOBEC3B(A3B) remains unknown. It has been confirmed that interleukin-6(IL-6)has significant impacts on oncogenesis of HCC. Here, we reported that the expression of IL-6 was substantially up-regulated by A3 B in HepG2 cells. A3 B induced IL-6 expression through relocating HuR to enhance the IL-6 mRNA stability. Further analysis indicated that IL-6 also increased the expression of A3 B through JAK1/STAT3 signaling pathway, which formed a positive feedback to maintain the continuous expression of A3 B and IL-6, and thereby promoted the prolonged non-resolving inflammation. Collectively, these findings suggest that A3 B is essential for oncogenesis of HCC, and is a potential target for preventive intervention. | Shuran Li Xueyang Bao Duowei Wang Linjun You Xianjing Li Hongbao Yang Jinsong Bian Yun Wang Yong Yang | 2017 | Science China(Life Sciences)2017，60，6： | 2 |
| 11 | Fabrication and luminescence of KGdF_4:Yb^(3+)/Er^(3+) nanoplates and their improving performance for polymer solar cells显示文摘Solar energy remains the most abundant renewable energy resource available to us[1].Continuous efforts have been invested to enhance the conversion of light to electricity by the diverse range of applications[2].Especially,polymer solar cells(PSCs)have reminded extensive attention own to flexibility,light-weight | Jiqing Jiao Yao Li Wenfei Shen Shasha Gai Jianguo Tang Yao Wang Linjun Huang Jixian Liu Wei Wang Laurence A.Belfiore | 2018 | Science Bulletin2018，63，4： | 2 |
| 12 | Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration显示文摘Inflammatory responses of nucleus pulposus(NP)can induce imbalanced anabolism and catabolism of extracellular matrix,and the cytosolic dsDNA accumulation and STING-NF-κB pathway activation found in NP inflammation are considered as fairly important cause of intervertebral disc(IVD)degeneration.Herein,we constructed a siSTING delivery hydrogel of aldehyde hyaluronic acid(HA-CHO)and poly(amidoamine)PAMAM/siRNA complex to intervene the abnormal STING signal for IVD degeneration treatment,where the formation of dynamic Schiff base bonds in the system(siSTING@HPgel)was able to overcome the shortcomings such as low cellular uptake,short half-life,and rapid degradation of siRNA-based strategy.PAMAM not only formed complexes with siRNA to promote siRNA transfection,but also served as dynamic crosslinker to construct hydrogel,and the injectable and self-healing hydrogel efficiently and steadily silenced STING expression in NP cells.Finally,the siSTING@HPgel significantly eased IVD inflammation and slowed IVD degeneration by prolonging STING knockdown in puncture-induced IVD degeneration rat model,revealing that STING pathway was a therapeutic target for IVD degeneration and such novel hydrogel had great potential for being applied to many other diseases for gene delivery. | Jiaxin Chen Haifeng Zhu Yutao Zhu Chenchen Zhao Shengyu Wang Yixin Zheng Ziang Xie Yang Jin Honghai Song Linjun Yang Jin Zhang Jiayong Dai Zhijun Hu Huaiyu Wang | 2022 | Bioactive Materials2022，7，3： | 2 |
| 13 | Modula- tion method of scroll compressor based on suction gas by- pass显示文摘 | Baolong Wang Linjun Han Wenxing Shi | 2012 | Applied Thermal Engineering2012，37，： | 1 |
| 14 | De- velopment of an integrated air conditioner with thermo- syphon and the application in mobile phone base station 显示文摘 | Han Linjun Shi Wenxing Wang Baolong | 2013 | International Journal of Refrigeration2013，36，1： | 1 |
| 15 | Ener- gy consumption model of integrated air conditioner with thermosyphon in mobile phone base station 显示文摘 | Han Linjun Shi Wenxing Wang Baolong | 2014 | Inter- national Journal of Refrigeration2014，40，： | 1 |
| 16 | Optimi- zation of refrigeration system with gas-injected scroll com- pressor显示文摘 | Baolong Wang Wenxing Shi Linjun Han | 2009 | International Journal of Refrigeration2009，32，7： | 1 |
| 17 | Emerging phagocytosis checkpoints in cancer immunotherapy显示文摘Cancer immunotherapy,mainly including immune checkpoints-targeted therapy and the adoptive transfer of engineered immune cells,has revolutionized the oncology landscape as it utilizes patients’own immune systems in combating the cancer cells.Cancer cells escape immune surveillance by hijacking the corresponding inhibitory pathways via overexpressing checkpoint genes.Phagocytosis checkpoints,such as CD47,CD24,MHC-I,PD-L1,STC-1 and GD2,have emerged as essential checkpoints for cancer immunotherapy by functioning as“don’t eat me”signals or interacting with“eat me”signals to suppress immune responses.Phagocytosis checkpoints link innate immunity and adaptive immunity in cancer immunotherapy.Genetic ablation of these phagocytosis checkpoints,as well as blockade of their signaling pathways,robustly augments phagocytosis and reduces tumor size.Among all phagocytosis checkpoints,CD47 is the most thoroughly studied and has emerged as a rising star among targets for cancer treatment.CD47-targeting antibodies and inhibitors have been investigated in various preclinical and clinical trials.However,anemia and thrombocytopenia appear to be formidable challenges since CD47 is ubiquitously expressed on erythrocytes.Here,we review the reported phagocytosis checkpoints by discussing their mechanisms and functions in cancer immunotherapy,highlight clinical progress in targeting these checkpoints and discuss challenges and potential solutions to smooth the way for combination immunotherapeutic strategies that involve both innate and adaptive immune responses. | Yu’e Liu Yanjin Wang Yanrong Yang Linjun Weng Qi Wu Jin Zhang Pengcheng Zhao Lan Fang Yufeng Shi Ping Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 18 | Effects of Homo-buffer Layer on Properties of Sputter-deposited ZnO Films显示文摘Two-step growth regimes were applied to realize a homoepitaxial growth of ZnO films on freestanding diamond substrates by radio-frequency(RF)reactive magnetron sputtering method.ZnO buer layers were deposited on freestanding diamond substrates at a low sputtering power of 50 W,and then ZnO main layers were prepared on this buffer layer at a high sputtering power of 150 W.For comparison,a sample was also deposited directly on freestanding diamond substrate at a power of 150 W.The effects of ZnO buffer layers on the structural, optical,electrical and morphological properties of the ZnO main layer were studied by X-ray diffraction(XRD), scanning electron microscopy(SEM),Raman spectroscopy,semiconductor characterization system and atomic force microscopy(AFM)respectively.The experimental results suggested that homo-buffer layer was helpful to improve the crystalline quality of ZnO/diamond heteroepitaxial films. | Jian Huang Linjun Wang Run Xu Weimin Shi Yiben Xia | 2009 | Journal of Materials Science & Technology2009，25，5： | 1 |
| 19 | CVD diamond devices for charged particle detection显示文摘 | Zhang Minglong Xia Yiben Wang Linjun | 2005 | Semicond Sci Technol2005，20，： | 1 |
| 20 | Effects of microstructure on the electrode properties of melt-spun Mg-based amorphous alloys 显示文摘 | Huang Linjun Tang Jianguo Wang Yao Liu Jixian Wu D C | 2009 | Journal of Alloys and Com- pounds2009，485，： | 1 |
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