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| 1 | Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile显示文摘AIM: To examine the presence of human papillomavirus (HPV) in esophageal squamous cell carcinoma (ESCC) specimens collected from Colombia and Chile located in the northern and southern ends of the continent, respectively. METHODS: We examined 47 and 26 formalin-fixed and paraffin-embedded ESCC specimens from Colombia and Chile, respectively. HPV was detected using GP5+/GP6+ primer pair for PCR, and confirmed by Southern blot analysis. Sequencing analysis of L1 region fragment was used to identify HPV genotype. In addition, P16INK4A protein immunostaining of all the specimens was conducted. RESULTS: HPV was detected in 21 ESCC specimens (29%). Sequencing analysis of L1 region fragment identified HPV-16 genome in 6 Colombian cases(13%) and in 5 Chilean cases (19%). HPV-18 was detected in 10 cases (21%) in Colombia but not in any Chilean case. Since Chilean ESCC cases had a higher prevalence of HPV-16 (without statistical significance), but a significantly lower prevalence of HPV-18 than in Colombian cases (P = 0.011) even though the two countries have similar ESCC incidence rates, the frequency of HPV-related ESCC may not be strongly affected by risk factors affecting the incidence of ESCC. HPV-16 genome was more frequently detected in p16 positive carcinomas, although the difference was not statistically significant. HPV-18 detection rate did not show any association with p16 expression. Well-differentiated tumors tended to have either HPV-16 or HPV-18 but the association was not statistically significant. HPV genotypes other than HPV-16 or 18 were not detected in either country. CONCLUSION: HPV-16 and HPV-18 genotypes can be found in ESCC specimens collected from two South American countries. Further studies on the relationship between HPV-16 presence and p16 expression in ESCC would aid understanding of the mechanism underlying the presence of HPV in ESCC. | Andres Castillo Francisco Aguayo Chihaya Koriyama Miyerlandi Torres Edwin Carrascal Alejandro Corvalan Juan P Roblero Cecilia Naquira Mariana Palma Claudia Backhouse Jorge Argandona Tetsuhiko Itoh Karem Shuyama Yoshito Eizuru Suminori Akiba | 2006 | World Journal of Gastroenterology2006，12，38： | 11 |
| 2 | 用传统方法与计算机辅助精液分析软件CRISMAS分析166名丹麦青年男性精液样本的结果比较显示文摘本研究以166名丹麦青年男性精液为样本,通过评估精于浓度和活力来比较传统精液分析与计算机辅助精液分析方法(CASA)(哥本哈根Rigshospitalet图像屋精子运动分析系统,CRISMAS软件4.6版本)。CRISMAS软件测定精子的浓度把精子活力分为三类。传统分析方法将精子活力分为四种状态。为了便于二者的比较,本文将传统的四种状态根据精子速度等级重新分为三个状态:rapidly progressive(A),slowly progressive(B)和non-progressive(C+D)。两种方法所研究的参数之间都有显著差异(P〈0.001)。与传统方法相比,CRISMAS高估了精子浓度以及快速运动精子的比例,因而低估了慢速运动和非运动精子。为分析研究结果是否会随精液分析时间而起伏变动,将精液分析结果按分析同期分为四个层次。结果表明CRISMAS对活力的分析结果比传统分析方法稳定,但两种方法都未表现出任何趋势。显然,无法比较CRISMAS CASA和传统分析方法在精子浓度和精子活力方面的分析结果。在临床上使用该软件时以及用其研究这些精子特性时需要说明这一点。 | Anne Vested Cecilia H Ramlau-Hansen Jens P Bonde Ane M Thulstrup Susanne L Kristensen Gunnar Toft | 2011 | Asian Journal of Andrology2011，13，3： | 3 |
| 3 | Performance, structure, and mechanism of CeO 2 in HCl oxidation to Cl 2显示文摘 | Amol P. Amrute Cecilia Mondelli Maximilian Moser Gerard Novell-Leruth Núria López Dirk Rosenthal Ramzi Farra Manfred E. Schuster Detre Teschner Timm Schmidt Javier Pérez-Ramírez | 2011 | Journal of Catalysis2011，，： | 2 |
| 4 | Risk aversion and rising wage inequality显示文摘 | Eve C Cecilia G P | 2002 | Economics Letters2002，77，1： | 1 |
| 5 | Water hyacinths as a resource in agriculture and energy production:A literature review显示文摘 | Carina C G Cecilia M P | 2007 | Waste Management2007，27，： | 1 |
| 6 | Studies of the synthesis of transition metal phosphides and their activity in the hydrodeoxy- genation of a biofuel model compound 显示文摘 | Bui P Cecilia J A Oyama S T | 2012 | J Catal2012，294，2： | 1 |
| 7 | Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification显示文摘 | Shuichi J Christopher P Cecilia MG | 2000 | J Bio Chem2000，275，20： | 1 |
| 8 | Two-round Delphi technique for the consensual design of a paediatric pharmaceutical care model 显示文摘 | Cecilia M Yolanda HG Maite P | 2013 | Pharmacological Research2013，68，1： | 1 |
| 9 | Single nucleotide polyrnorphism discovery in rainbow trout by deep sequenc- ing of a reduced representation library显示文摘 | Cecilia C S Timothy P S Ralph T W | 2009 | BMC Genom2009，10，： | 1 |
| 10 | Adipocytokines, Insulin Resistance, and Coronary Athero- sclerosis in Rheumatoid Arthritis 显示文摘 | Rho Young Hee Chung Cecilia P Solus Joseph F | 2010 | Arthritis & Rheu- matism2010，62，5： | 1 |
| 11 | Nuclear run-on analysis of var gene expression in Plasmodium falciparum 显示文摘 | Elise S Judith M P Cecilia P S | 2007 | Mol Biochem Parasitol2007，153，2： | 1 |
| 12 | A versatile indirect detector design for hard X-ray micro imaging显示文摘 | Douissard P A Cecilia A Rochet X | 2012 | Journal of Instrumentation2012，7，09： | 1 |
| 13 | Natural Capital and Qutility of Life:a Model for Evaluating the Sustainability of Alternative Regional Development Paths显示文摘 | Cecilia& Duane Timothy P | 1999 | Ecological Economics1999，30，： | 1 |
| 14 | Involvement of soluble Fas Ligand in germ cell apoptosis in testis of rats undergoing autoimmune orchitis显示文摘 | Patricia Verónica Jacobo Mónica Fass Cecilia Valeria Pérez Sabrina Jarazo-Dietrich Livia Lustig María Susana Theas | 2012 | Cytokine2012，，2： | 1 |
| 15 | Carbohydrate synthesis by two Navicula strains isolated from benthic and pelagic mucilages in the Tyrrhenian Sea (Tuscan Archipelago)显示文摘 | Cecilia F Roberto D P Claudio S | 2003 | Applied Phycology2003，，15： | 1 |
| 16 | A rapid method of Sertoli cell isolation by DSA lectin,allowing mitotic analyses显示文摘 | Stefania S Anna R Cecilia P | 1998 | Mol Cellu Endocrinol1998，146，2： | 1 |
| 17 | Notes on some species of the related genera Aegyptobia Sayed, Phytoptipalpus Trasardh and Pentamerismus McGregor, with descriptions of eight new species (Acari: Tenuipalpidae)显示文摘 | Smith P Cecilia J | 1993 | Genus1993，4，4： | 1 |
| 18 | Bulblet differentiation afterscale propagation of Lilium longiflorum显示文摘 | Pablo A M Luis F H Cecilia P P | 2003 | Journal of the AmericanSociety for Horticultural Science2003，128，3： | 1 |
| 19 | A short synthesis of astemizole 显示文摘 | Cecilia A P Leticia Q C Jesus S R | 1996 | Synthetic Communication1996，26，17： | 1 |
| 20 | Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification显示文摘 | Christopher P Cecilia MG | 2000 | J Bio Chem2000，275，20： | 1 |
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