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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 3 | Experimental studies in the LENS supersonic and hypersonic tunnels for hypervelocity vehicle performance and code validation 显示文摘 | Michael S H Timothy P W Matthew M | 2008 | AIAA2008，2505，： | 1 |
| 4 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 5 | Single-step purifica- tion/solubilization of recombinant proteins: Application to surfactant protein B显示文摘 | Andreas H Karen S P Timothy E W | 1996 | Bio Tech1996，，20： | 1 |
| 6 | Developments in nanoscienee: Polyhedral oligomerie silsesquioxane (POSS)-polymers显示文摘 | Shawn H P Timothy S H Sandra J T | 2004 | Current Opinion in Solid State and Materials Science2004，8，1： | 1 |
| 7 | Startup and operation of a supercritical carbon dioxide Brayton cycle 显示文摘 | Eric M C Timothy L C Christopher P S | 2014 | Journal of Engineering for Gas Turbines and Power2014，136，： | 1 |
| 8 | Scaling up:the next challenge in environmental microbiology 显示文摘 | Hans W P and Timothy F S | 2003 | Environmental Microbiology2003，5，11： | 1 |
| 9 | Roles of amino acids 161 to 179 in the PSE-4 omega-Loop in substrate specificity and in resistance to ceftazidime 显示文摘 | Christian T Francois S Timothy P | 1998 | Antimicrob Agents Chemother1998，42，10： | 1 |
| 10 | Brugada Phenocopy: New Terminology and Proposed Classification显示文摘 | Adrian Baranchuk Timothy Nguyen Min Hyung Ryu Francisco Femenía Wojciech Zareba Arthur A.M. Wilde Wataru Shimizu Pedro Brugada Andrés R. Pérez‐Riera | 2012 | Annals of Noninvasive Electrocardiology2012，，4： | 1 |
| 11 | Bacillus Calmette–Guerin immunotherapy for urothelial carcinoma of the bladder显示文摘 | Timothy P Kresowik Thomas S Griffith | 2009 | Immunotherapy2009，，2： | 1 |
| 12 | Single nucleotide polyrnorphism discovery in rainbow trout by deep sequenc- ing of a reduced representation library显示文摘 | Cecilia C S Timothy P S Ralph T W | 2009 | BMC Genom2009，10，： | 1 |
| 13 | Molecular characterization of a virulent canine coronavirus BGF strain显示文摘 | Jose M S Scott P Timothy H M | 2004 | Virus Res2004，140，： | 1 |
| 14 | Earlyblood-brain barrier permeability in cerebella of PISJL miceimmunized with myelin basic protein显示文摘 | Sergei S Carla P Timothy W | 2008 | J Neuroimmunol2008，196，12： | 1 |
| 15 | Influence of the molar mass distribution on the elongational behavior of polymer solutions in capillary breakup显示文摘 | Lucy E R Timothy P S Justin J C | | 0，，1： | 1 |
| 16 | Effect of Coagulant Type and Storage Temperature on the Functionality of Reduced-Fat Mozzarella Cheese显示文摘 | JEREMIAH J S KATHLEEN O S TIMOTHY P G | 2004 | EDP Sciences2004，84，： | 1 |
| 17 | Aortoiliac Icsufficiency:Long-term Experience with Stent Placement for Treatment显示文摘 | Timothy P Murphy MD Nikki S Ariaratnam BA Wilfred I Carney | 2004 | Radiology2004，，231： | 1 |
| 18 | A systems approach to modeling drug release from polymer microspheres to accelerate in vitro to in vivo translation 显示文摘 | Timothy D K Steven R L Robert S P | 2015 | Journal of Controlled Release2015，211，： | 1 |
| 19 | Chemical in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages 显示文摘 | Timothy S Martin P Kaszubowski N | 1999 | J Immunol1999，163，10： | 1 |
| 20 | Structural and magneticproperties of nanoscale iron oxide particles synthesized in the presence of dextran or polyvinyl alcohol 显示文摘 | HEATH P WANIDA C TIMOTHY G S P | 2001 | J Magn Magn Mater2001，225，： | 1 |
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