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| 1 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 2 | Rheological model for self-consolidating concrete 显示文摘 | BUI V K AKKAYA Y SHAH S P | 2002 | ACI Materials Journal2002，99，6： | 1 |
| 3 | Technique for measurement of power-line impedance in the frequency range from 500 kHz to 500 MHz 显示文摘 | Kwasniok P J Bui M D Kozlowski A J | 1993 | IEEE Trans on Electromagnetic Compatibility1993，35，1： | 1 |
| 4 | Building online crisis management support using workflow systems 显示文摘 | Mak H Y Mallard A P Bui T | 1999 | Decision Support Systems1999，，25： | 1 |
| 5 | Numerical simulation of cold roll-forming processes 显示文摘 | Bui Q V Ponthot J P | 2008 | Journal of Materials Processing Technology2008，202，： | 1 |
| 6 | Adiponectin induces LKB1/AMPK-dependent glucose uptake via actin cy- toskeleton remodeling 显示文摘 | VI V BUI P EGUCHI M | 2013 | J Mol Endocrinol2013，51，1： | 1 |
| 7 | Anther developmentaldefects in Arabidopsis thaliana male-sterile mutants显示文摘 | Sanders P M Bui A Q Weterings K | 1999 | SexualPlant Reproduction1999，11，： | 1 |
| 8 | Hydrodeoxygenation of guaiacol with CoMo catalysts Part I Promoting effect of cobalt on HDO selectivity and activity显示文摘 | BUI V N LAURENTI D AFANASIEV P | 2011 | Applied Catalysis B: Environmental2011，101，34： | 1 |
| 9 | Flexible diamond- like carbon film coated on rubber 显示文摘 | Pei Y T Bui X L van der Pal J P | 2013 | Progress in Organic Coatings2013，76，12： | 1 |
| 10 | Role of epigenetic mechanisms in differential regulation of the dioxin-inducible human CYP1A1 and CYP1B1 genes显示文摘 | Beedanagari SR Taylor RT Bui P Wang F Nickerson DW Hankinson O | 2010 | Mol Pharmacol2010，78，4： | 1 |
| 11 | Studies of the synthesis of transition metal phosphides and their activity in the hydrodeoxy- genation of a biofuel model compound 显示文摘 | Bui P Cecilia J A Oyama S T | 2012 | J Catal2012，294，2： | 1 |
| 12 | Numerical simulation of cold roll-forming processes 显示文摘 | Bui Q V Ponthot J P | 2008 | Journal of Materials Processing Technology2008，202，1： | 1 |
| 13 | Optical flow techniques or moving target detection显示文摘 | Russo P Marandey V Bui T | 1990 | SPIE1990，1383，： | 1 |
| 14 | Numerical simulation of springback using enhanced assumed strain elements显示文摘 | BUI Q V PAPELEUX L PONTHOT J P | 2004 | Journal of Materials Processing Technology2004，，： | 1 |
| 15 | Hydrodeoxygenation of guaiacol as model compound for pyrolysis oil on transition metal phosphide hydroprocessing catalysts 显示文摘 | Zhao H Y Li D Bui P | 2011 | Applied Catalysis A: General2011，391，12： | 1 |
| 16 | SSH adequacy to preimplantation mammalian development: Scarce specific transcripts cloning despite irregular normalisation 显示文摘 | Bui L C L6andri R D Renard J P | 2005 | BMC Genomics2005，，6： | 1 |
| 17 | Blood pressure and heart rate effects following a single dose of bitter orange显示文摘 | Bui L T Nguyen D T Ambrose P J | 2006 | Ann Pharmacother2006，40，： | 1 |
| 18 | Claudins in teleost fishes显示文摘 | KOLOSOV D BUI P CHASIOTIS H | 2013 | Tissue Barriers2013，1，25： | 1 |
| 19 | ARBAS: A formal language to support argumentation in network-based organizations显示文摘 | Bui T X Bodart F Ma P | 1997 | Journal of Management Information Systems1997，14，3： | 1 |
| 20 | Lipid prodrug nanocar-riers in cancer therapy显示文摘 | MURA S BUI D T COUVREUR P | 2015 | Journal of Controlled Release2015，208，： | 1 |
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