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| 1 | Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile显示文摘AIM: To examine the presence of human papillomavirus (HPV) in esophageal squamous cell carcinoma (ESCC) specimens collected from Colombia and Chile located in the northern and southern ends of the continent, respectively. METHODS: We examined 47 and 26 formalin-fixed and paraffin-embedded ESCC specimens from Colombia and Chile, respectively. HPV was detected using GP5+/GP6+ primer pair for PCR, and confirmed by Southern blot analysis. Sequencing analysis of L1 region fragment was used to identify HPV genotype. In addition, P16INK4A protein immunostaining of all the specimens was conducted. RESULTS: HPV was detected in 21 ESCC specimens (29%). Sequencing analysis of L1 region fragment identified HPV-16 genome in 6 Colombian cases(13%) and in 5 Chilean cases (19%). HPV-18 was detected in 10 cases (21%) in Colombia but not in any Chilean case. Since Chilean ESCC cases had a higher prevalence of HPV-16 (without statistical significance), but a significantly lower prevalence of HPV-18 than in Colombian cases (P = 0.011) even though the two countries have similar ESCC incidence rates, the frequency of HPV-related ESCC may not be strongly affected by risk factors affecting the incidence of ESCC. HPV-16 genome was more frequently detected in p16 positive carcinomas, although the difference was not statistically significant. HPV-18 detection rate did not show any association with p16 expression. Well-differentiated tumors tended to have either HPV-16 or HPV-18 but the association was not statistically significant. HPV genotypes other than HPV-16 or 18 were not detected in either country. CONCLUSION: HPV-16 and HPV-18 genotypes can be found in ESCC specimens collected from two South American countries. Further studies on the relationship between HPV-16 presence and p16 expression in ESCC would aid understanding of the mechanism underlying the presence of HPV in ESCC. | Andres Castillo Francisco Aguayo Chihaya Koriyama Miyerlandi Torres Edwin Carrascal Alejandro Corvalan Juan P Roblero Cecilia Naquira Mariana Palma Claudia Backhouse Jorge Argandona Tetsuhiko Itoh Karem Shuyama Yoshito Eizuru Suminori Akiba | 2006 | World Journal of Gastroenterology2006，12，38： | 11 |
| 2 | sTWEAK is a marker of early haematoma growth and leukoaraiosis in intracerebral haemorrhage显示文摘Objective To study the association between early growth of haematoma with biomarkers of endothelial dysfunction such as leukoaraiosis(LA)and the soluble tumour necrosis factor-like weak inducer of apoptosis(sTWEAK)in patients with intracerebral haemorrhage(ICH).Methods This is a retrospective observational study of patients with nontraumatic ICH.Clinical and biochemical parameters were analysed.sTWEAK levels were measured by ELISA.LA was analysed in the hemisphere without haemorrhage to avoid interference with the acute injury.The main endpoint was the haematoma growth evaluated by the difference in volume between the second and the initial neuroimage.Poor functional outcome,defined as a modified Rankin Scale>2 at 3 months,was considered as secondary endpoint.Receiver operating characteristic curve analysis was performed to stablish the best cut-off for sTWEAK levels associated with haematoma growth.Results We included 653 patients with ICH in our analysis(71.1±11.9 years,44%women).Haematoma growth was observed in 188 patients(28.8%).sTWEAK levels≥5600 pg/mL predicted ICH growth with a sensitivity of 84%and a specificity of 87%.sTWEAK levels≥5600 pg/mL and the presence of LA were associated with haematoma growth(OR:42.46;(CI 95%22.67 to 79.52)and OR:2.73(CI 95%1.39 to 5.34),respectively).Also,the presence of LA(OR:4.31(CI 95%2.89 to 6.42))and the interaction between ICH growth and sTWEAK(OR:2.23(CI 95%1.40 to 3.55))were associated with poor functional outcome at 3 months.Conclusion sTWEAKs,together with the presence and grade of LA,are biomarkers able to predict ICH growth and poor functional outcome in patients with ICH. | Andrés da Silva-Candal Iria López-Dequidt Manuel Rodriguez-Yañez PauloÁvila-Gómez JoséManuel Pumar JoséCastillo Tomás Sobrino Francisco Campos Ramón Iglesias-Rey Pablo Hervella | 2021 | Stroke & Vascular Neurology2021，6，4： | 2 |
| 3 | Renal Function in Patients With Cadaveric Kidney Transplants Treated With Tacrolimus or Cyclosporine显示文摘 | M. Gonzalez Molina J.M. Morales R. Marcen J.M. Campistol F. Oppenheimer D. Serón S. Gil-Vernet L. Capdevila A. Andrés I. Lampreave D. Del Castillo M. Cabello D. Burgos F. Valdés F. Anaya F. Escuín M. Arias L. Pallardó J. Bustamante | 2007 | Transplantation Proceedings2007，，7： | 1 |
| 4 | Flameassisted synthesis of nanoscale, amorphous and crystalline, spherical BiVO4 with visible-light photocatalytic activity 显示文摘 | Castillo Nikola C Heel Andre Graule Thomas | 2010 | Applied Catalysis B : Environmental2010，95，34： | 1 |
| 5 | Human papillomavirus in upper digestive tract tumors from three countries显示文摘AIM: To clarify human papillomavirus (HPV) involvement in carcinogenesis of the upper digestive tract of virological and pathological analyses. METHODS: The present study examined the presence of HPV in squamous cell carcinomas of the oral cavity (n = 71), and esophagus (n = 166) collected from Japan, Pakistan and Colombia, with different HPV exposure risk and genetic backgrounds. The viral load and physical status of HPV16 and HPV16-E6 variants were examined. Comparison of p53 and p16INK4a expression in HPV-positive and HPV-negative cases was also made. RESULTS: HPV16 was found in 39 (55%) oral carcinomas (OCs) and 24 (14%) esophageal carcinomas (ECs). This site-specific difference in HPV detection between OCs and ECs was statistically significant (P < 0.001). There was a significant difference in the geographical distribution of HPV16-E6 variants. Multiple infections of different HPV types were found in 13 ECs, but multiple infections were not found in OCs. This difference was statistically significant (P = 0.001). The geometric means (95% confidence interval) of HPV16 viral load in OCs and ECs were 0.06 (0.02-0.18) and 0.12 (0.05-0.27) copies per cell, respectively. The expression of p16INK4a proteins was increased by the presence of HPV in ECs (53% and 33% in HPV-positive and-negative ECs, respectively; P = 0.036), and the high-risk type of the HPV genome was not detected in surrounding normal esophageal mucosa of HPV-positive ECs. CONCLUSION: Based on our results, we cannot deny the possibility of HPV16 involvement in the carcinogenesis of the esophagus. | Andres Castillo Chihaya Koriyama Michiyo Higashi Muhammad Anwar Mulazim Hussain Bukhari Edwin Carrascal Lida Mancilla Hiroshi Okumura Masataka Matsumoto Kazumasa Sugihara Shoji Natsugoe Yoshito Eizuru Suminori Akiba | 2011 | World Journal of Gastroenterology2011，17，48： | 1 |
| 6 | Purification of Gastroprotective Triterpenoids from the Stem Bark of Amphipterygium adstringens; Role of Prostaglandins, Sulfhydryls, Nitric Oxide and Capsaicin-Sensitive Neurons显示文摘 | Jesús Arrieta Javier Benitez Edith Flores Carlos Castillo Andrés Navarrete | 2003 | Planta Med2003，，： | 1 |
| 7 | Bacteriocin production by Bifidobacterium spp. A review显示文摘 | Fabio Andres Castillo Martinez Eduardo Marcos Balciunas Attilio Converti Paul D. Cotter Ricardo Pinheiro de Souza Oliveira | 2013 | Biotechnology Advances2013，，4： | 1 |
| 8 | Lactic acid properties, applications and production: A review显示文摘 | Fabio Andres Castillo Martinez Eduardo Marcos Balciunas José Manuel Salgado José Manuel Domínguez González Attilio Converti Ricardo Pinheiro de Souza Oliveira | 2012 | Trends in Food Science & Technology2012，，： | 1 |
| 9 | Novel biotechnological appli cations of bacteriocins: A review显示文摘 | Eduardo Marcos Balciunas Fabio Andres Castillo Martinez Svetosla Dimitrov Todorov | 2013 | Food Control2013，，13： | 1 |
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