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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | GenomeWide Identification of Nodule-Specific Transcripts in the Model Legume Medicago truncatula显示文摘 | Fedorova M Judith van de Mortel Matsumoto P A | 2002 | Plant Physiol2002，130，： | 1 |
| 3 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 4 | Carboxymethylation of cashew tree exudate polysaecharide 显示文摘 | I)URCII ENE A S REGINA C M JUDITH P A | 2004 | Carbohydrate Polymers2004，58，2： | 1 |
| 5 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 6 | Nuclear run-on analysis of var gene expression in Plasmodium falciparum 显示文摘 | Elise S Judith M P Cecilia P S | 2007 | Mol Biochem Parasitol2007，153，2： | 1 |
| 7 | The analysis of cell images显示文摘 | JUDITH M S P MENDELSOHN M L | 1966 | Annals of the New York Academy of Sciences1966，128，1： | 1 |
| 8 | Chronic Fatigue Syndrome 显示文摘 | Judith B P Jos W M Gils B | 2006 | Lancet2006，367，： | 1 |
| 9 | Environmental fate of explosives显示文摘 | Judith C P James M B | 2002 | Thermoehimiea Aeta2002，384，： | 1 |
| 10 | Phenotypic Characterization and Course of Chronic Obstructive Pulmonary Disease in the PAC -COPD Study: Design and Methods显示文摘 | Judith Garcia-Aymericha Federico P G6mezb Josep M Ant6a | 2009 | Archivos de Bronconeu- mologfa ((English Edition))2009，，45： | 1 |
| 11 | Gene discovery in the adenophorean nematode Trichinella spiralis : an analysis of transcription from life cycle stages显示文摘 | Makedonka M Douglas P J Judith A | 2004 | Mol Biochem Parasitol2004，137，： | 1 |
| 12 | Multiplex PCR assay and simple preparation method for stool specimens detect enterotoxigenic Esch erichia coli DNA during course of infection显示文摘 | Sandrina S P James J M Judith B W | 1995 | Journal of clinical microbio logy1995，33，5： | 1 |
| 13 | Experimental growth responses to groundwater level variation and competition in five British wetland plant species显示文摘 | Kennedy M P Judith M M Kevin J M | 2003 | Wetlands Ecology and Management2003，11，： | 1 |
| 14 | Preparation, purification, and characterization of aminopropyl-functionalized silica sol 显示文摘 | Marcell P Livia N N Judith M etal | 2013 | Colloid and Interface Science2013，390，： | 1 |
| 15 | Environmental fate of explosives显示文摘 | Judith C P James M B | 2002 | Thermochimica Acta2002，，384： | 1 |
| 16 | Comparative reliability and validiy of chronic pain intensity measure显示文摘 | Mark P Jensen Judith A Turner Joan M Romano | 1999 | Pain1999，83，： | 1 |
| 17 | Aplastie anemia : firstline treatment by immunosuppression and sibling marrow transplantation显示文摘 | JAKOB R P JUDITH C W M | 2010 | ASH2010，，： | 1 |
| 18 | ISSR, ERIC, and RAPD techniques to detect genetic diversity in the aphid pathogen Pandora neoaphidis显示文摘 | ANNA M T JUDITH K P | 2005 | Mycological Research2005，109，3： | 1 |
| 19 | Hormone therapy: Physiological complexity belies therapeutic simplicity显示文摘 | Judith L T Donald P M Kathryn A M | 2004 | Science2004，304，5675： | 1 |
| 20 | Experimental growth responses to groundwater levelvariation and competition in five British wetland plant species显示文摘 | Kennedy M P Judith M M Kevin J M | 2003 | Wetlands Ecology andManagement2003，11，： | 1 |
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