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| 1 | Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration显示文摘在到女繁殖的道的从男性的旅行,哺乳动物的精子经验自然渗透的减少(例如在老鼠,从 ~ 在到 ~ 的尾 epididymis 的 415 mOsm 在子宫的洞的 310 mOsm ) 。精子演变为活动性激活利用这张力减退的暴露,同时高效地沉默张力减退的房间胀大的否定影响。以前的生理并且药理学研究显示出那个离子控制隧道的水流入 / 流出活跃地涉及精子的过程体积规定;然而,没有特定的精子蛋白质为这快速的 osmoadaptation 被发现负责。这里,我们报导 aquaporin3 (AQP3 ) 是在老鼠和人的一条精子水隧道。Aqp3 缺乏的精子响应张力减退显示出正常活动性激活,但是显示增加的危险到张力减退的房间胀大,在进入以后,由增加的尾巴弯曲描绘了子宫。精子缺点是在男性女性的繁殖的道转变期间响应生理的张力减退的应力胀大的损害精子体积规定和进步房间的结果。微速摄影的成像表明房间体积扩大在细胞质的微滴开始,强迫尾巴到有角并且由于机械膜段形成像发卡的结构。尾巴变丑妨碍了精子移植进输卵管,导致损害授精并且减少了男富饶。这些数据为精子作为一条必要的膜小径建议 AQP3 平衡 “ 的规章的卷减少(RVD ) ; trade-off”在在生理的张力减退之上胀大的精子活动性和房间之间,从而优化 postcopulatory 精子行为。 | Qi Chen Hongying Peng Li Lei Ying Zhang Haibin Kuang Yujing Cao Qi-xian Shi Tonghui Ma Enkui Duan | 2011 | Cell Research2011，21，6： | 13 |
| 2 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 3 | Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection显示文摘 | Yunfang Zhang Ying Zhang Junchao Shi He Zhang Zhonghong Cao Xuan Gao Wanhua Ren Yunna Ning Lina Ning Yujing Cao Yongchang Chen Weizhi Ji Zi-jiang Chen Qi Chen Enkui Duan | 2014 | Journal of Molecular Cell Biology2014，8，2： | 10 |
| 4 | Development of mouse preimplantation embryos in space显示文摘The development o f life beyond planet Earth is a long-standing quest of the human race,but whether normal mammalian embryonic development can occur in space is still unclear.Here,we show unequivocally that preimplantation mouse embryos can develop in space;but the rate of blastocyst formation and blastocyst quality are compromised.Additionally,the cells in the embryo contain severe DNA damage,while the genome of the blastocysts developed in space is globally hypomethylated with a unique set of differentially methylated regions.The developmental defects,DNA damage and epigenetic abnormalities can be largely mimicked by the treatment with ground-based low-dose radiation.However,the exposure to simulated microgravity alone does not cause major disruptions of embryonic development,indicating that radiation is the main cause for the developmental defects.This work advances the understanding of embryonic development in space and reveals long-term extreme low-dose radiation as a hazardous factor for mammalian reproduction. | Xiaohua Lei Yujing Cao Baohua Ma Yunfang Zhang Lina Ning Jingjing Qian Liwen Zhang Yongcun Qu Tao Zhang Dehong Li Qi Chen Junchao Shi Xudong Zhang Chiyuan Ma Ying Zhang Enkui Duan | 2020 | National Science Review2020，7，9： | 8 |
| 5 | Enrichment of putative human epidermal stem cells based on cell size and collagen type IV adhesiveness显示文摘人的表皮的干细胞(EpSCs ) 的丰富和鉴定具有为基本研究和临床的申请的首要的重要性。尽管为 EpSCs 的丰富的几条途径被建立了,充实可行 EpSCs 的一张纯人口仍然是一项挑战性的任务。一条改进途径值得发展提高 EpSCs 的纯净和生存能力。这里,我们报导那种房间尺寸与骨胶原类型 IV 粘着性结合了能在一条改进途径被使用充实纯、可行的人的 EpSCs。我们分开了很快支持者 keratinocytes 进从 5-7 microm (人口 A )在尺寸 的三张人口到 7-9 microm (人口 B ),到>或在直径的 =9 microm (人口 C ),并且发现人的通常认为的 EpSCs 能进一步与最小的尺寸在人口 A 被充实。在三张人口之中,人口 A 显示了 beta1-integrin 受体的最高的密度,在 G0/G1 阶段包含了房间的最高的百分比,显示出最高的原子核到细胞质比率,并且拥有了最高的殖民地形成效率(CFE ) 。当注入了鼠科的胚囊时,这些房间参予了多织物形成。与根据 beta1-integrin 抗体染色排序通常认为的 EpSCs 的一条以前的途径相比,更显著地, EpSCs 的生存能力由改进途径充实显著地被提高。我们的结果为人的 EpSCs 的丰富提供通常认为的策略,并且在干细胞生物学鼓励进一步的学习进房间尺寸的角色。 | Juxue Li Chenglin Miao Welxiang Guo Liwei Jia Jiaxi Zhou Baohua Ma Sha Peng Shuang Liu Yujing Cao Enkui Duan | 2008 | Cell Research2008，18，3： | 8 |
| 6 | Induction of matrix metalloproteinase-9 and-2 activity in mouse blastocyst by fibronectin-integrin interaction显示文摘Fibronectin, a major extracellular matrix, plays an important role in embryo implantation by mediating embryo adhesion and outgrowth. In this work, mouse blastocysts produced pro-matrix metalloproteinase-9, pro-matrix metalloproteinase-2 and 64 ku matrix metalloproteinase-2 when they were co-cultured with fibronectin. In contrast, mouse blastocysts did not produce these proteinases without fibronectin. Focal adhesion kinase is a fundamental molecule of integrin signaling pathway and its antisense oligodeoxynucleiotide inhibited blastocyst matrix metalloproteinases expression induced by fibronectin. The results indicated that fibronectin triggered matrix metalloproteinase-9 and -2 expression in mouse blastocyst through its integrin receptors and subsequent signaling pathway, which enhanced the synchronization of blastocyst invasiveness and uterine receptivity and ensured the accuracy of events relative to implantation in timing and spatiality. | TIE Guodong CAO Yujing ZHAO Xingxu Duan Enkui | 2000 | Chinese Science Bulletin2000，45，14： | 7 |
| 7 | The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer显示文摘Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous cells1 that play crucial negative regulatory roles in immune-associated diseases,including infections,2 cancer,3 transplantation4,and autoimmunity.5 We and others have shown that mTOR signaling and its downstream metabolic pathways regulate MDSC recruitment and function in inflammation and autoimmunity. | Anna Jia Yuexin Wang Yufei Wang Yan Li Qiuli Yang Yejin Cao Ying He Lin Dong Yingjie Dong Yueru Hou Ruoning Wang Yujing Bi Guangwei Liu | 2021 | Cellular & Molecular Immunology2021，18，4： | 7 |
| 8 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
| 9 | Role of αVβ3 integrin in embryo implantation in the mouse显示文摘Integrin, a heterodimeric adhesive molecule composed of a and (5 subunits, can regulate cell adhesion and trafficking. Recent data have documented that, at the 'implantation window' stage, aVp3 integrin participates in the maternal-fetal interaction and becomes a potential marker of uterine receptivity. Furthermore, it can affect invasiveness of embryo. This work made a further study about its action mechanism. Results of indirect immunofluorescence and laser scanning confocal microscopy showed that αVβ3 integrin was clearly expressed in the mouse blastocyst. Injection of αVβS integrin antiserum into a uterine horn of a pregnant mouse on day 3 markedly decreased the number of embryos implanted (P < 0.001). In a co-culture model, aVp3 integrin antisera at 1 : 100 and 1 : 200 dilutions significantly depressed the attachment and outgrowth reactions of blastocysts on monolayer of uterine epithelial cells. Analysis of correlation manifested that the inhibitory effect of αVβ3 integrin antiserum was | Liquan Cai Yujing Cao Enkui Duan | 2000 | Chinese Science Bulletin2000，45，22： | 6 |
| 10 | Basic Characteristics,Spatial Disparity and Its Major Influencing Factors of Service Industry in China显示文摘Based on the analysis of its basic characteristics,this article investigated the disparities of Chinese service industry among the three regions(the eastern China,the western China and the middle China) and inter-provincial disparities of that in the three regions by Theil coefficient and cluster analysis.Then,major factors influencing its spatial disparity were explored by correlation analysis and regression analysis.The conclusions could be drawn as follows.1) The development of Chinese service industry experienced three phases since the 1980s:rapid growth period,slow growth period,and recovery period.From the proportion of value-added and employment,its development was obviously on the low level.From the composition of industrial structure,traditional service sectors were dominant,but modern service sectors were lagged.Moreover,its spatial disparity was distinct.2) The level of Chinese service industry was divided into five basic regional ranks:well-developed,developed,relatively-developed,underdeveloped and undevel-oped regions.As a whole,the overall structure of spatial disparity was steady in 1990-2005.But there was notable gradient disparity in the interior structure of service industry among different provinces.Furthermore,the overall disparity expanded rapidly in 1990-2005.The inter-provincial disparity of service industry in the three regions,especially in the eastern China,was bigger than the disparity among the three regions.And 3) the level of economic development,the level of urban development,the scale of market capacity,the level of transportation and telecommunication,and the abundance of human resources were major factors influencing the development of Chinese service industry. | SHEN Yuming QIU Ling REN Wangbing CAO Yi HU Dan SONG Yujing | 2009 | Chinese Geographical Science2009，19，4： | 6 |
| 11 | Effect of fibronectin and leukaemia inhibitory factor on matrix metalloproteinases in mouse blastocyst显示文摘This study was designed to detect the effects of fibronectin (FN) and leukaemia inhibitory factor (LIF) on matrix metallopoteinases (MMPs) of mouse blastocysts. The experiments comprised four groups: first, blastocysts grew on the dishes with FN-coated; the second, without FN-coated; the third group, without FN coated, but with 20 ng/μL LIF added to culture medium; and the fourth group, with both FN-coated and 20 ng/μL LIF added. Using MMP-2 and MMP-9 primers respectively, the expressions of MMP-2 and MMP-9 were detected by RT-PCR and cloning identification. The results showed that in the first group, MMP-2 and MMP-9 were produced after 12 and 24 h culturing; in the third group, there were both MMP-2 and MMP-9 bands when blastocysts were cultured for 24 h; and in the fourth group, MMP-2 and MMP-9 bands appeared when blastocysts were cultured for 6, 12 and 24 h. But in the second group no MMP-2 or MMP-9 band appeared. These results show that FN may initiate the transcription of MMP-2 and MMP-9 genes | Jian Zhang Guodong Tie Yujing Cao Enkui Duan | 2001 | Chinese Science Bulletin2001，46，15： | 4 |
| 12 | Antiviral activity of Jinchai capsule against influenza virus显示文摘OBJECTIVE:To evaluate the effect on influenza virus of Jinchai,a capsule made of Traditional Chinese Medicine.METHODS:Madin-darby canine kidney(MDCK) cells were infected with the FM1 strain of influenza virus A(subtype H1N1) in vitro.They were used to explore how Jinchai affected cell adsorption,cell membrane fusion,transcription and replication of the influenza virus.Hemagglutinin(HA) protein,intracellular pH,and influenza virus protein acid(PA) polymerase subunit were detected with confocal microscopy and real-time fluorescent quantitative polymerase chain reaction.RESULTS:Jinchai significantly reduced the expression of HA and PA polymerase subunit mRNA in infected MDCK cells.Jinchai also significantly decreased intracellular pH in infected cells.CONCLUSIONS:Jinchai had strong anti-influenza activity against the influenza virus.It weakened the ability of the influenza virus to adsorb to cell wall and fuse with cell membranes in the early infection stage,and inhibited the transcription and replication of the virus. | Juying Zhong Xiaolan Cui Yujing Shi Yingjie Gao Hongxin Cao | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 4 |
| 13 | VlicroRNA-495 induces breast cancer ce migration by targeting JAM-A显示文摘 | Minghui Cao Weiwei Nie Jing Li Yujing Zhang Xin Yan Xiaoxiang Guan Xi Chen Ke Zen Chen-yu Zhang Xiaohong Jiang Dongxia Hou | 2014 | Protein & Cell2014，5，11： | 4 |
| 14 | mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration显示文摘Hair follicles(HFs)undergo cycles of degeneration(catagen),rest(telogen),and regeneration(anagen)phases.Anagen begins when the hair follicle stem cells(HFSCs)obtain sufficient activation cues to overcome suppressive signals,mainly the BMP pathway,from their niche cells.Here,we unveil that mTOR complex 1(mTORC1)signaling is activated in HFSCs,which coincides with the HFSC activation at the telogen-to-anagen transition.By using both an inducible conditional gene targeting strategy and a pharmacological inhibition method to ablate or inhibit mTOR signaling in adult skin epithelium before anagen initiation,we demonstrate that HFs that cannot respond to mTOR signaling display significantly delayed HFSC activation and extended telogen.Unexpectedly,BMP signaling activity is dramatically prolonged in mTOR signaling-deficient HFs.Through both gain-and loss-of-function studies in vitro,we show that mTORC1 signaling negatively affects BMP signaling,which serves as a main mechanism whereby mTORC1 signaling facilitates HFSC activation.Indeed,in vivo suppression of BMP by its antagonist Noggin rescues the HFSC activation defect in mTORC1-null skin.Our findings reveal a critical role for mTOR signaling in regulating stem cell activation through counterbalancing BMP-mediated repression during hair regeneration. | Zhili Deng Xiaohua Lei Xudong Zhang Huishan Zhang Shuang Liu Qi Chen Huimin Hu Xinyue Wang Lina Ning Yujing Cao Tongbiao Zhao Jiaxi Zhou Ting Chen Enkui Duan | 2015 | Journal of Molecular Cell Biology2015，7，1： | 3 |
| 15 | IGF-Ⅱ and IGFBP-1 reversely regulate blastocyst implantation in mouse显示文摘Insulin-like growth factor (IGF)-Ⅱ and IGF binding protein (IGFBP)-1, members of IGF family, are important in the cyclic development of endometrium and the blastocyst implantation. In the present study, the indirect immunofluorescence showed that IGF- Ⅱ and IGFBP-1 were specifically expressed at the maternal-fetal interface. In a co-culture system, IGF-Ⅱ significantly enhanced the attachment and outgrowth of the blastocyst on monolayer of uterine epithelial cells, while IGFBP-1 did not affect the blastocyst attachment, but markedly inhibited the blastocyst outgrowth. The results of zymography showed that IGF- Ⅱ enhanced the activities of MMP-2 and MMP-9, while IGFBP-1 did not affect the activities of MMP-2 and MMP-9. In conclusion, the equilibrium between the invasion of tro-phoblast and the inhibition of deciduas may be regulated by the interaction between the IGF- Ⅱ -expressing invading cy-totrophoblast and maternal deciduas-derived IGFBP-1. | TIAN Yongqiang, TIE Guodong, CAO Yujing, ZHAO Xingxu & DUAN Enkui1. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China 2. College of Vet Medicine, Gansu Agricultural University, Lanzhou 730070, China | 2002 | Chinese Science Bulletin2002，47，21： | 3 |
| 16 | The expression and function of VEGF at embryo implantation 'window' in the mouse显示文摘Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen that plays a critical role in angiogenesis. Recent reports indicated that VEGF was closely involved in embryo implantation and embryonic vasculogenesis. However, very little information is available about the detailed expression and function of VEGF at implantation 'window'. In this work, VEGFs were primarily present on uterine epithelial cell monolayer and blasto-cysts including the outgrew trophoblasts at implantation window. VEGF antibodies decreased the number of mice embryos implanted and the percentage of blastocysts with attachment and outgrowth in a co-culture model in a dose-dependant manner. These findings demonstrate that VEGF is one of the essential cytokines for embryo implantation in mouse. VEGF may act as a local mediator to regulate the maternal-fetal interaction, and facilitate blastocyst implantation. | Jing Zhang Li Wang Liquan Cai Yujing Cao Enkui Duan | 2001 | Chinese Science Bulletin2001，46，5： | 2 |
| 17 | Effects of vascular endothelial growth factor on MMPs during embryo implantation in mice显示文摘Vascular endothelial growth factor (VEGF) is a specific mitogen of endothelial cells and plays an important role in vasculogenesis and angiogenesis. In recent years, both our and other laboratories have found that VEGF may be involved in embryo implantation. However, the relationship between VEGF and MMP-2 and MMP-9, the marker molecules of embryo implantation, is still unknown. In the present study, an examination of the effects of VEGF on the expression and secretion of MMP-2 and MMP-9 during implantation in mice was carried out by RT-PCR and gelatin zymography. The results show that VEGF antibody significantly decreased uterine mRNA levels of MMP-2 and MMP-9 during pregnancy, and that VEGF could up-regulate the activities of MMP-2 and MMP-9 secreted by blastocysts cultured in vitro in a time- and dose-dependent manner. The results suggest that, in the course of implantation, the ability for metastasis and invasion of blastocysts and the receptive-ness of the uterus might be regulated by VEGF | LI Sumin CAO Yujing ZHANG Jian TIAN Yongqiang ZHENG Xing DUAN Enkui | 2002 | Chinese Science Bulletin2002，47，24： | 2 |
| 18 | Electro-Fenton oxidation of pesticides with a novel Fe 3 O 4 @Fe 2 O 3 /activated carbon aerogel cathode: High activity, wide pH range and catalytic mechanism显示文摘 | Hongying Zhao Yujing Wang Yanbin Wang Tongcheng Cao Guohua Zhao | 2012 | Applied Catalysis B: Environmental2012，，： | 2 |
| 19 | Transcriptomic Response to Yersinia pestis:RIG-I Like Receptor Signaling Response Is Detrimental to the Host against Plague显示文摘Bacterial pathogens have evolved various mechanisms to modulate host immune responses for successful infection.In this study,RNAsequencing technology was used to analyze the responses of human monocytes THP1 to Yersinia pestis infection.Over 6000 genes were differentially expressed over the 12 h infection.Kinetic responses of pathogen recognition receptor signaling pathways,apoptosis,antigen processing,and presentation pathway and coagulation system were analyzed in detail.Among them,RIG-I-like receptor(RLR) signaling pathway,which was established for antiviral defense,was significantly affected.Mice lacking MAVS,the adaptor of the RLR signahng pathway,were less sensitive to infection and exhibited lower IFN-P production,higher Thl-type cytokines IFN-y and IL-12 production,and lower Th2-type cytokines EL-4 and IL-13 production in the serum compared with wild-type mice.Moreover,infection of pathogenic bacteria other than Y.pestis also altered the expression of the RLR pathway,suggesting that the response of RLR pathway to bacterial infection is a universal mechanism. | Zongmin Du Huiying Yang Yafang Tan Guang Tian Qingwen Zhang Yujun Cui Yanfeng Yan Xiaohong Wu Zuyun Chen Shiyang Cao Yujing Bi Yanping Han Xiaoyi Wang Yajun Song Ruifu Yan | 2014 | Journal of Genetics and Genomics2014，41，7： | 2 |
| 20 | Embryo implantation:A time for recalling and forwarding显示文摘The success of embryo implantation is a critical step towards further embryo development and pregnancy outcome. The observations and investigations on embryo implantation have been over a century. A huge body of knowledge has been accumulated in anatomy, histology, ultrastructure and hormonal regulation; as well as recently in depth information about molecular signaling pathways got from studies of genomic wide gene screening and specific gene deletion. The knowledge from basic research has also substantially helped to initiate and improve the Artificial Reproductive Technology (ART) in clinical applications. Now we've known that the normal embryo implantation involves the embryo's development into an implantation-competent blastocyst and the synchronized transformation of uteri into a receptive stage. The interdependent relationship between the blastocyst and uterus involves complicated hormonal regulation and local paracrine, juxtacrine interactions. In this paper, we review some important historical findings regarding uterine receptivity and blastocyst activation, as well as some less discussed topics such as embryo spacing, embryo orientation. Further understandings on detailed mechanisms during the process of embryo implantation will help cure women infertility as well as develop new generation of non-steroids contraceptives. | CHEN Qi PENG HongYing ZHANG Ying LEI Li CAO YuJing Duan EnKui | 2009 | Chinese Science Bulletin2009，54，22： | 2 |
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