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| 1 | Multi-Stage Basin Development and Hydrocarbon Accumulations: A Review of the Sichuan Basin at Eastern Margin of the Tibetan Plateau显示文摘Sichuan Basin is one of the uppermost petroliferous basins in China. It experienced three evolutionary phases which were marine carbonate platform(Ediacaran to Late Triassic), Indosinian-Yanshanian orogeny foreland basin(Late Triassic to Late Cretaceous) and uplift and tectonic modification(Late Cretaceous to Quaternary). The present-day tectonics of the Sichuan Basin and its periphery are characterized by three basic elements which are topography, basement type and surface structure, and two settings(plate margin and interior). Therefore, be subdivided into five units which have different structure and tectonic history. The basin contains five different sets of source rocks with thickness up to 2 500 m. These source rocks were well preserved due to the presence of Middel–Lower Triassic evaporites(>~200 m) and thick terrestrial sediments filling in the Indosinian-Yanshanian foreland basin(>3 000 m). The uplift and erosion since Late Cretaceous has significant influence on cross-strata migration and accumulation of oil and gas. The multi-phase evolution of the basin and its superimposed tectonic elements, good petroleum geologic conditions and diverse petroleum systems reveal its bright exploration prospects. | Shugen Liu Bin Deng Luba Jansa Zhiwu Li Wei Sun Guozhi Wang Zhili Luo Ziquan Yong | 2018 | Journal of Earth Science2018，29，2： | 17 |
| 2 | Development and applications of functional gene microarrays in the analysis of the functional diversity,composition,and structure of microbial communities显示文摘Functional gene arrays(FGAs)are a special type of microarrays containing probes for key genes involved in microbial functional processes,such as biogeochemical cycling of carbon,nitrogen,sulfur,phosphorus,and metals,biodegradation of environmental contaminants,energy processing,and stress responses.GeoChips are considered as the most comprehensive FGAs.Experimentally established probe design criteria and a computational pipeline integrating sequence retrieval,probe design and verification,array construction,data analysis,and automatic update are used to develop the GeoChip technology.GeoChip has been systematically evaluated and demonstrated to be a powerful tool for rapid,specific,sensitive,and quantitative analysis of microbial communities in a high-throughput manner.Several generations of GeoChip have been developed and applied to investigate the functional diversity,composition,structure,function,and dynamics of a variety of microbial communities from different habitats,such as water,soil,marine,bioreactor,human microbiome,and extreme ecosystems.GeoChip is able to address fundamental questions related to global change,bioenergy,bioremediation,agricultural operation,land use,human health,environmental restoration,and ecological theories and to link the microbial community structure to environmental factors and ecosystem functioning. | Zhili HE Joy DVAN NOSTRAND Ye DENG Jizhong ZHOU | 2011 | Frontiers of Environmental Science & Engineering2011，5，1： | 9 |
| 3 | mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration显示文摘Hair follicles(HFs)undergo cycles of degeneration(catagen),rest(telogen),and regeneration(anagen)phases.Anagen begins when the hair follicle stem cells(HFSCs)obtain sufficient activation cues to overcome suppressive signals,mainly the BMP pathway,from their niche cells.Here,we unveil that mTOR complex 1(mTORC1)signaling is activated in HFSCs,which coincides with the HFSC activation at the telogen-to-anagen transition.By using both an inducible conditional gene targeting strategy and a pharmacological inhibition method to ablate or inhibit mTOR signaling in adult skin epithelium before anagen initiation,we demonstrate that HFs that cannot respond to mTOR signaling display significantly delayed HFSC activation and extended telogen.Unexpectedly,BMP signaling activity is dramatically prolonged in mTOR signaling-deficient HFs.Through both gain-and loss-of-function studies in vitro,we show that mTORC1 signaling negatively affects BMP signaling,which serves as a main mechanism whereby mTORC1 signaling facilitates HFSC activation.Indeed,in vivo suppression of BMP by its antagonist Noggin rescues the HFSC activation defect in mTORC1-null skin.Our findings reveal a critical role for mTOR signaling in regulating stem cell activation through counterbalancing BMP-mediated repression during hair regeneration. | Zhili Deng Xiaohua Lei Xudong Zhang Huishan Zhang Shuang Liu Qi Chen Huimin Hu Xinyue Wang Lina Ning Yujing Cao Tongbiao Zhao Jiaxi Zhou Ting Chen Enkui Duan | 2015 | Journal of Molecular Cell Biology2015，7，1： | 3 |
| 4 | Design, Synthesis and Activities of Aziridine Derivatives of N^5-Methyltetrahydrofolate Against Methionine Synthase显示文摘 | DENG Xiling GUO Ying TIAN Chao LIU Junyi WANG Xiaowei ZHANG Zhili | 2015 | Chemical Research in Chinese Universities2015，31，5： | 2 |
| 5 | Research on tracked vehicles HMT test-bed mensure and control system显示文摘 | Cheng Guangwei Zhou Zhili Deng Chunan | 2007 | Journal of Wuhan University of Technology (Transportation Science & Engineering)2007，8，4： | 1 |
| 6 | Network succession reveals the importance of competition in response to emulsified vegetable oil amendment for uranium bioremediation显示文摘 | Ye Deng Ping Zhang Yujia Qin Qichao Tu Yunfeng Yang Zhili He Christopher Warren Schadt Jizhong Zhou | 2016 | Environ Microbiol2016，，1： | 1 |
| 7 | GeoChip 4: a functional gene‐array‐based high‐throughput environmental technology for microbial community analysis显示文摘 | Qichao Tu Hao Yu Zhili He Ye Deng Liyou Wu Joy D. Van Nostrand Aifen Zhou James Voordeckers Yong‐Jin Lee Yujia Qin Christopher L. Hemme Zhou Shi Kai Xue Tong Yuan Aijie Wang Jizhong Zhou | 2014 | Mol Ecol Resour2014，，5： | 1 |
| 8 | Electrochemical quartz crystal microbalance monitoring of the cyclic voltammetric deposition of polyaniline -A laboratory experiment for undergraduates 显示文摘 | Qingji Xie Zhili Li Chunyan Deng | 2007 | Journal of Chemical Education2007，84，： | 1 |
| 9 | A visualization pipeline for in vivo two-photon volumetric astrocytic calcium imaging显示文摘Astrocytes,the multi-functional glial cells with the most abundant population in the brain,integrate information across their territories to regulate neuronal synaptic and cerebrovascular activities.Astrocytic calcium(Ca^(2+))signaling is the major readout of cellular functional state of astrocytes.The conventional two-photon in vivo imaging usually focuses on a single horizontal focal plane to capture the astrocytic Ca^(2+)signals,which leaves>80%spatial information undetected.To fully probe the Ca^(2+)activity across the whole astrocytic territory,we developed a pipeline for imaging and visualizing volumetric astrocytic Ca^(2+)time-lapse images.With the pipeline,we discovered a new signal distribution pattern from three-dimensional(3D)astrocytic Ca^(2+)imaging data of mice under isoflurane anesthetic states.The tools developed in this study enable a better understanding of the spatiotemporal patterns of astrocytic activity in 3D space. | Qian Sun Yusi Hu Saiyue Deng Yanyu Xiong Zhili Huang | 2022 | The Journal of Biomedical Research2022，36，5： | 1 |
| 10 | Scientific Advances and Weather Services of the China Meteorological Administration’s National Forecasting Systems during the Beijing 2022 Winter Olympics显示文摘Since the Beijing 2022 Winter Olympics was the first Winter Olympics in history held in continental winter monsoon climate conditions across complex terrain areas,there is a deficiency of relevant research,operational techniques,and experience.This made providing meteorological services for this event particularly challenging.The China Meteorological Administration(CMA)Earth System Modeling and Prediction Centre,achieved breakthroughs in research on short-and medium-term deterministic and ensemble numerical predictions.Several key technologies crucial for precise winter weather services during the Winter Olympics were developed.A comprehensive framework,known as the Operational System for High-Precision Weather Forecasting for the Winter Olympics,was established.Some of these advancements represent the highest level of capabilities currently available in China.The meteorological service provided to the Beijing 2022 Games also exceeded previous Winter Olympic Games in both variety and quality.This included achievements such as the“100-meter level,minute level”downscaled spatiotemporal resolution and forecasts spanning 1 to 15 days.Around 30 new technologies and over 60 kinds of products that align with the requirements of the Winter Olympics Organizing Committee were developed,and many of these techniques have since been integrated into the CMA’s operational national forecasting systems.These accomplishments were facilitated by a dedicated weather forecasting and research initiative,in conjunction with the preexisting real-time operational forecasting systems of the CMA.This program represents one of the five subprograms of the WMO’s high-impact weather forecasting demonstration project(SMART2022),and continues to play an important role in their Regional Association(RA)II Research Development Project(Hangzhou RDP).Therefore,the research accomplishments and meteorological service experiences from this program will be carried forward into forthcoming highimpact weather forecasting activities.This article provides an overview and assessment of this program and the operational national forecasting systems. | Guo DENG Xueshun SHEN Jun DU Jiandong GONG Hua TONG Liantang DENG Zhifang XU Jing CHEN Jian SUN Yong WANG Jiangkai HU Jianjie WANG Mingxuan CHEN Huiling YUAN Yutao ZHANG Hongqi LI Yuanzhe WANG Li GAO Li SHENG Da LI Li LI Hao WANG Ying ZHAO Yinglin LI Zhili LIU Wenhua GUO | 2024 | Advances in Atmospheric Sciences2024，41，5： | 0 |
| 11 | Design of Optical System in Solar Blind Ultraviolet and Study on the Detection Distance显示文摘 | Jiang Bo Zhou Sizhong Jiang Kai Duan Jing Deng Xiaoguo Guo Zhili | 2012 | 光学学报2012，32，F12： | 0 |
| 12 | Plasma Extracellular Vesicle MicroRNA Analysis of Alzheimer’s Disease Reveals Dysfunction of a Neural Correlation Network显示文摘Small extracellular vesicle(sEV)is an emerging source of potential biomarkers of Alzheimer's disease(AD),but the role of microRNAs(miRNAs)in sEV is not well understood.In this study,we conducted a comprehensive analysis of sEV-derived miRNAs in AD using small RNA sequencing and coexpression network analysis.We examined a total of 158 samples,including 48 from AD patients,48 from patients with mild cognitive impairment(MCI),and 62 from healthy controls.We identified an miRNA network module(M1)that was strongly linked to neural function and showed the strongest association with AD diagnosis and cognitive impairment.The expression of miRNAs in the module was decreased in both AD and MCI patients compared to controls.Conservation analysis revealed that M1 was highly preserved in the healthy control group but dysfunctional in the AD and MCI groups,suggesting that changes in the expression of miRNAs in this module may be an early response to cognitive decline prior to the appearance of AD pathology.We further validated the expression levels of the hub miRNAs in M1 in an independent population.The functional enrichment analysis showed that 4 hub miRNAs might interact with a GDF11-centered network and play a critical role in the neuropathology of AD.In summary,our study provides new insights into the role of sEV-derived miRNAs in AD and suggests that M1 miRNAs may serve as potential biomarkers for the early diagnosis and monitoring of AD. | Yuzhe Sun Zhen Hefu Benchao Li Wang Lifang Song Zhijie Li Zhou Yan Deng Liu Zhili Jiahong Ding Tao Li Wenwei Zhang Nie Chao Shuang Rong | 2023 | Research2023，，4： | 0 |
| 13 | The First Global Map of Atmospheric Ammonia(NH_(3)) as Observed by the HIRAS/FY-3D Satellite显示文摘Atmospheric ammonia(NH_(3)) is a chemically active trace gas that plays an important role in the atmospheric environment and climate change. Satellite remote sensing is a powerful technique to monitor NH_(3) concentration based on the absorption lines of NH_(3) in the thermal infrared region. In this study, we establish a retrieval algorithm to derive the NH_(3)column from the Hyperspectral Infrared Atmospheric Sounder(HIRAS) onboard the Chinese Feng Yun(FY)-3D satellite and present the first atmospheric NH_(3) column global map observed by the HIRAS instrument. The HIRAS observations can well capture NH_(3) hotspots around the world, e.g., India, West Africa, and East China, where large NH_(3) emissions exist. The HIRAS NH_(3) columns are also compared to the space-based Infrared Atmospheric Sounding Interferometer(IASI)measurements, and we find that the two instruments observe a consistent NH_(3) global distribution, with correlation coefficient(R) values of 0.28–0.73. Finally, some remaining issues about the HIRAS NH_(3) retrieval are discussed. | Minqiang ZHOU Zhili DENG Charles ROBERT Xingying ZHANG Lu ZHANG Yapeng WANG Chengli QI Pucai WANG Martine De MAZIÈRE | 2024 | Advances in Atmospheric Sciences2024，41，3： | 0 |
| 14 | Sensing Traction Strain Induces Cell-Cell Distant Communications显示文摘Mechanobiology has been a highly recognized field in studying the importance of physical forces in physiologies at the molecular,cellular,tissue,organ and body-levels.Beside the intensive work focusing on the fine local biomechanical forces,the long-range force which can propagate through a relatively distant scale(in hundreds of micrometers and beyond)has been an intriguing topic with increasing attentions in recent years.The collective functions at cell population level often rely on cell-cell communications with or without direct contacts.Recent progresses including our own work indicate that the long-range biomechanical force propagating across scales far beyond single cell size may reserve the capability to trigger coordinative biological responses within cell population.Whether and how cells communicate mechanically in a distant manner remains largely to be explored.In respiratory system,the mechanical property of airway smooth muscle(ASM)is associated with asthma attack with prolonged contraction during airway hyper-responsiveness.In this work,we found that ASM cells rapidly self-assembled into a well-constructed network on 3D matrigel containing type I collagen(COL I),which required the collective functions and coordination of thousands of cells completed within 12-16 hours.Cells were assembled with aligned actin stress fibers and elongated nuclei.The assembling process relied on the long-range mechanical forces across the matrix to direct cell-cell distant interactions.We further found that single ASM cells could rapidly initiate multiple buds precisely pointing to neighboring cells in distance,which relied on cell traction force and force strain on the matrix.Beads tracking assay demonstrated the long-range transmission of cellular traction force to distant locations,and modeling of maximum strain distribution on matrix by finite element method predicted the consistency with cell directional protrusions and movements in experiments.Cells could sense each other in distance to move directionally on both non-fibrous matrigel and in much more efficient way when containing COL I.Cells recruited COL I from the hydrogel to build nearly identical COL I fibrous network to mechanically stabilize the cell network.Our results revealed that ASM cells can sense the traction strain transmitted through matrix to initiate distant communications and rapidly coordinate the network assembly at the population level through active cell-matrix interactions.As an interesting phenomenon,cells sound able to’make phone call’via the role of long-range mechanical force.In summary,this work demonstrated that long-range biomechanical force facilitates the collective functions of ASM cell population for network assembly.The cells reacted to traction strain on the matrix for distant communications,which resulted in directional budding and movement.Fibrous COL I had important roles in facilitating the efficiency of force transmission to induce the assembly and stabilizing the cell network.This work has helped advance the understanding of the feature andfunction of long-range biomechanical force at the cell population level.The observed high mechano-sensitivity of ASM cells might suggest a re-enforced feedback of enhanced contraction by excessive ASM under asthmatic condition. | Zhili Qian Yang Jin Bing Bu Yan Pan Linhong Deng Mingxing Ouyang | 2019 | 医用生物力学2019，34，A01： | 0 |
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