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| 1 | Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome显示文摘AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS). METHODS: 18 patients with IBS (Rome Ⅱ criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of f irst rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no signifi cant improvement in the symptom score with probiotic therapy, except for wind (P=0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median fi nal score 5.3 (IQR3.9-5.9), 55% reduction; n=6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these fi ndings awaits a randomised, controlled trial. | Jacqueline S Barrett Kim EK Canale Richard B Gearry Peter M Irving Peter R Gibson | 2008 | World Journal of Gastroenterology2008，14，32： | 16 |
| 2 | Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘 | José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste | 2014 | The Journal of Molecular Diagnostics2014，，1： | 2 |
| 3 | Graft function, histopathology and morphometry of radial arteries used as conduits for myocardial revascularization in patients beyond age 70显示文摘 | Wildhirt S M Voss B yon Canal F | 2006 | Eur J Cardiothorac Surg2006，30，2： | 1 |
| 4 | Surgical management of the calyceal diverticulum 显示文摘 | Canales B Monga M | 2003 | Curr Opin Urol2003，13，： | 1 |
| 5 | Surgical management of the calyceal diverticu- lum显示文摘 | Canales B Monga M | 2003 | Curt Opin Urol2003，13，3： | 1 |
| 6 | Pharmacy- and community-based screenings for diabetes and cardiovascular conditions in high-risk individuals显示文摘 | SNELLA K A CANALES A E IRONS B K | 2006 | J Am Pharm Assoc2006，46，3： | 1 |
| 7 | Minimally invasive approaches to upper urinary tract urolithiasis显示文摘 | WIGNALL G R CANALES B K DENSTEDT J D | 2008 | Urol Clin N Am2008，35，： | 1 |
| 8 | Osmotic dehydration of raspberries with vacuum pretreatment followed by microwave-vacuum drying显示文摘 | Bórquez R M Canales E R Redon J P | 2010 | Journal of Food Engineering2010，99，2： | 1 |
| 9 | Surgical management of the calyceal diverticulum显示文摘 | CANALES B MONGA M | 2003 | Curr Opin Urol2003，13，3： | 1 |
| 10 | Complexes ofmacrocycles with pendantarms as models for biologicalmolecules显示文摘 | Costamagna J Ferraudi G Matsuhiro B Campos-Vallette M Canales J Villagran M Vargas J Aguirre M J | | 0，，： | 1 |
| 11 | Sleep-disordered breathing and urinary albumin excretion in older men显示文摘 | CANALES M T PAUDEL M L TAYLOR B C | 2011 | Sleep Breath2011，15，： | 1 |
| 12 | Seismic reflection imaging of an oceanic detachment fault: Atlantis megamullion (Mid-Atlantic Ridge, 3010tN)显示文摘 | CANALES J P TUCHOLKE B E COLLINS J A | 2004 | Earth and Planetary Science Letters2004，222，2： | 1 |
| 13 | A practical two-step quantitative clinical and electrophysiological assessmentfor the diagnosis and staging of diabetic neuropathy 显示文摘 | Feldman E L Stevens M J Thomas P K Brown M B Canal N Greene D A | 1994 | Diabetes Care1994，17，： | 1 |
| 14 | Kinematics and geometry of active detachment faulting beneath the Trans-Atlantic Geotra- verse(TAG)hydrothermal field on the Mid-Atlantic Ridge显示文摘 | deMartin B J Sohn R A Canales J P | 2007 | Geology2007，，8： | 1 |
| 15 | Graft func- tion, histopathology and morphometry of radial arteries used as conduits for myocardial revascularization in pa- tients beyond age 70显示文摘 | Wildhirt S M Voss B von Canal F | 2006 | Eur J Cardiothorac Surg2006，30，2： | 1 |
| 16 | Clostridium hungatei sp nov, a mesophilic, N2 -fixing cellulolytic bacterium isolated from soil 显示文摘 | Monserrate E Leschine S B Canale - Parola E | 2001 | Int J Syst Evol Microbiol2001，51，1： | 1 |
| 17 | Surgical managemenl oI the calyceal diverticulum显示文摘 | Canales B Monga M | 2003 | Curr Opin Urol2003，13，3： | 1 |
| 18 | Solution NMR structure of a human FGF-1 monomer, activated by a hexasaecharide heparin-analogue显示文摘 | Canales A Lozano R Lopez-Mendez B | 2006 | FEBS J2006，273，20： | 1 |
| 19 | Second prize: Comprehensive proteomic analysis of human cal- cium oxalate monohydrate kidney stone matrix显示文摘 | Canales B K Anderson L Higgins L | 2008 | J Endourol2008，22，6： | 1 |
| 20 | Mesophilic Cellulolytic Clostridia from Freshwater Environments显示文摘 | LESCHINE S B CANALE P E | 1983 | Applied and Environmental Microbiology1983，46，3： | 1 |
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