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| 1 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 2 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 3 | How LDL receptors influence cholesterol and atherosclerosos显示文摘 | Brown M S Goldstein J L | 1984 | scientific American1984，251，： | 2 |
| 4 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 5 | Organizaing knowledge显示文摘 | Brown J S Duguid P | 1998 | California Management Review1998，40，： | 2 |
| 6 | 气缸孔粗糙度对机油耗影响的试验研究显示文摘侧重于内燃机机油耗控制中的一个重要因素。以前的研究工作已经通过理论或试验方法建立了气缸孔粗糙度与机油耗之间的关系。在本研究中,利用回归分析和新的瞬态放射性示踪剂机油耗测量法所得到的试验数据用统计学方法推导出了一个数学模型。该模型可预测机油耗随气缸孔粗糙度变化的期望值,并能提出确定和控制最低机油耗的重要气缸孔表面粗糙度参数。 | Hill S H Kantola T C Brown J R 孙书麒 | 1998 | 国外内燃机1998，30，3： | 2 |
| 7 | 2004英国高血压学会高血压治疗指南(BHS-IV):概要显示文摘在高血压领域,不断出现的新证据已日益受到关注。例如:血压可作为心血管疾病的一个危险因素;改进生活方式对于预防和治疗高血压的重要意义;不同类型药物的有效性和安全性;高危高血压患者包括糖尿病患者的治疗;心血管疾病总体危险性评估的重要性以及使用他汀类药物所获得的额外益处。 | Bryan Williams Neil R Poulter Peter S Sever Morris J Brown Mark Davis Gordon T McInnes John F Potter 邱洪 | 2004 | 英国医学杂志中文版2004，7，5： | 2 |
| 8 | Nutritional properties of microalgae for mariculture显示文摘 | Brown M R Jeffrey S W Volkman J K | 1997 | Aquaculture1997，151，： | 2 |
| 9 | Effective interventions for lifestyle change after myocardial infarction or coronary artery revascularization显示文摘 | COBB S L BROWN D J DAVIS L L | 2006 | J Am Acad Nurs Pract2006，18，1： | 1 |
| 10 | Postmenopausal hormones and incontinence:The heart and estrogen/progestin replacement study显示文摘 | Grady D Brown J S Vittinshof E | 2001 | Obstet Gynecol2001，97，1： | 1 |
| 11 | Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998显示文摘 | Brown B A Oberste M S Alexander J P | 1999 | J Virol1999，73，： | 1 |
| 12 | Toxic shock syndrome in a horse with Staphylococcus aureus pneumonia显示文摘 | HOLBROOK T C MUNDAY J S BROWN C A | 2003 | J Am Vet Med Assoc2003，222，5： | 1 |
| 13 | The mathematics of Statistical Machine Translation: Parameter Estimation显示文摘 | Brown P F Della Pietra V J Della Pietra S A | 1993 | Compu- tational Linguistics1993，19，2： | 1 |
| 14 | Financing innovation and growth: Cash flows, external equity, and the 1990s R&D Boom显示文摘 | Brown J Fazzari S Petersen B | 2009 | Journal of Finance2009，，64： | 1 |
| 15 | Analysis of fMRI data by blind separation into independent spatial components 显示文摘 | Mckeown M J Makelg S Brown G G Jung T P Kinderman S S Bell A J and Sejnowski T J | 1998 | Human Brain Mapping1998，6，： | 1 |
| 16 | Nitrogen availability in disturbed,rehabilitated and mature forests of tropical China显示文摘 | MO J M BROWN S PENG S L | 2003 | Forest Ecology and Management2003，175，3： | 1 |
| 17 | Deleterious rhizosphere bacteria:An integrating perspectice显示文摘 | Nehl D B Allen S J Brown J F | 1996 | Applied Soil Ecology1996，5，： | 1 |
| 18 | The SREBP pathway:regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor显示文摘 | Brown M S Goldstein J L | 1997 | Cell1997，89，： | 1 |
| 19 | Modeling of biological processes using self-cycling fermentation and genetic algorithms显示文摘 | Pinchuk R J Brown W A Hughes S M | 2000 | Biotechnoi Bioeng2000，，67： | 1 |
| 20 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
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