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| 1 | Genome-wide SNP Genotyping Resolves Signatures of Selection and Tetrasomic Recombination in Peanut显示文摘花生(Arachis hypogaea;2n = 4x = 40 ) 是滋养的食物和维生素,矿物质,和健康脂肪的好来源。扩大基因并且为栽培花生的基因改进的 genomic 资源从栽培花生的双祖先的定序的染色体获得了动量。便于 Arachis 种类的高产量的 genotyping, 20 遗传型被重新定序,染色体宽的单个核苷酸多型性(SNP ) 被选择开发一个大规模 SNP genotyping 数组。为在 genotyping 应用程序的灵活性,在 tetraploid 和双种类之间多态的 SNP 为使用被包括在栽培并且种间的人口。一套 384 就职被用来测试导致生产了在双种类之间的高质量的多态的簇的 54 564 个标记的数组, 47 116 个多态的标记在之间栽培并且种间的混血儿,和在 A 以内的 15 897 个多态的标记。hypogaea germplasm。一另外 1193 个标记被识别那照亮的 genomic 区域展出 tetrasomic 再结合。而且,完成美国跑步者 germplasm 的家谱的一套精英栽培变种是 genotyped 并且过去常识别经历了积极选择的 genomic 区域。这些观察在栽培花生在新基因差异的包括上提供关键卓见并且将通知发展高分辨率的印射的人口。由于它的效率,范围,和灵活性,最新发达的 SNP 数组将为在 Arachis 的进一步基因、引起的应用程序是很有用的。 | Josh Clevenger Ye Chu Carolina Chavarro Gaurav Agarwal David J. Bertioli Soraya C.M. LeaI-Bertioli Manish K. Pandey Justin Vaughn Brian Abernathy Noelle A. Barkley Ran Hovav Mark Burow Spurthi N. Nayak Annapurna Chitikineni Thomas G. Isleib C. Corley Holbrook Scott A. Jackson Rajeev K. Varshney Peggy Ozias-Akins | 2017 | Molecular Plant2017，10，2： | 4 |
| 2 | Trophic factors are essential for the survival of grafted oligodendrocyte progenitors and for neuroprotection after perinatal excitotoxicity显示文摘The consequences of neonatal white matter injury are devastating and represent a major societal problem as currently there is no cure.Prematurity,low weight birth and maternal pre-natal infection are the most frequent causes of acquired myelin deficiency in the human neonate leading to cerebral palsy and cognitive impairment.In the developing brain,oligodendrocyte(OL)maturation occurs perinatally,and immature OLs are particularly vulnerable.Cell replacement therapy is often considered a viable option to replace progenitors that die due to glutamate excitotoxicity.We previously reported directed specification and mobilization of endogenous committed and uncommitted neural progenitors by the combination of transferrin and insulin growth factor 1(TSC1).Here,considering cell replacement and integration as therapeutic goals,we examined if OL progenitors(OLPs)grafted into the brain parenchyma of mice that were subjected to an excitotoxic insult could rescue white matter injury.For that purpose,we used a well-established model of glutamate excitotoxic injury.Four-day-old mice received a single intraparenchymal injection of the glutamate receptor agonist N-methyl-D-aspartate alone or in conjunction with TSC1 in the presence or absence of OLPs grafted into the brain parenchyma.Energetics and expression of stress proteins and OL developmental specific markers were examined.A comparison of the proteomic profile per treatment was also ascertained.We found that OLPs did not survive in the excitotoxic environment when grafted alone.In contrast,when combined with TSC1,survival and integration of grafted OLPs was observed.Further,energy metabolism in OLPs was significantly increased by N-methyl-D-aspartate and modulated by TSC1.The proteomic profile after the various treatments showed elevated ubiquitination and stress/heat shock protein 90 in response to N-methyl-D-aspartate.These changes were reversed in the presence of TSC1 and ubiquitination was decreased.The results obtained in this pre-clinical study indicate that the use of a combinatorial intervention including both trophic support and healthy OLPs constitutes a promising approach for long-term survival and successful graft integration.We established optimal conditioning of the host brain environment to promote long-term survival and integration of grafted OLPs into an inflamed neonate host brain.Experimental procedures were performed under the United States Public Health Service Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Animal Care Committee at(UCLA)(ARC#1992-034-61)on July 1,2010. | Megumi Hirose-Ikeda Brian Chu Paul Zhao Omar Akil Elida Escalante Laurent Vergnes Carlos Cepeda Araceli Espinosa-Jeffrey | 2020 | Neural Regeneration Research2020，15，3： | 4 |
| 3 | Cellular protein kinase C isozyme regulation by exogenously delivered physiological disulfides-implications of oxidative protein kinase C regulation to cancer prevention显示文摘 | CHEN LH O'BRIAN CA | 2004 | Carcinogenesis2004，25，4： | 1 |
| 4 | Prospects for Targeting Protein Kinase C Isozymes in the Therapy of Drug-resistant Cancer – An Evolving Story显示文摘 | Catherine A. O’Brian Nancy E. Ward Jubilee R. Stewart Feng Chu | 2001 | Cancer and Metastasis Reviews2001，，1： | 1 |
| 5 | Cellular protein kinase C isozyme regulation by exogenously delivered physiological disulfides-implications of oxidative protein kinase C regulation to cancer prevention显示文摘 | Chu F Chen LH O'Brian CA | 2004 | Carcillogenesis2004，25，4： | 1 |
| 6 | Dynamic Hepatitis C Virus Genotypic and Phenotypic Changes in Patients Treated With the Protease Inhibitor Telaprevir显示文摘 | Christoph Sarrazin Tara L. Kieffer Doug Bartels Brian Hanzelka Ute Müh Martin Welker Dennis Wincheringer Yi Zhou Hui–May Chu Chao Lin Christine Weegink Henk Reesink Stefan Zeuzem Ann D. Kwong | 2007 | Gastroenterology2007，，5： | 1 |
| 7 | GNSS Receiver Evaluation Record and Playback Test Methods显示文摘 | Brian Weinstein Dennis Akos Eric Vinande Tianxing Chu | 2009 | GPS World2009，17，： | 1 |
| 8 | 为便携式系统设计线性锂离子电池充电器显示文摘本文通过对比镍氢电池和锂离子电池特性说明了锂离子电池在便捷式系统设计中的优势,进而展示了几种常用的锂离子电池充电器的设计方法,可为相关工程师提供设计参考。 | Brian Chu | 2009 | 电子设计应用2009，，11： | 1 |
| 9 | The optical properties of porcine nasal cartilage 显示文摘 | Steen J Madsen Eugene A Chu Brian J F | 1999 | IEEE Journal of Selected Topic in Quantum Electronics1999，5，4： | 1 |
| 10 | Microbial resistance to nanotechnologies:An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants显示文摘Microbial resistance to current antibiotics therapies is a major cause of implant failure and adverse clinical outcomes in orthopaedic surgery.Recent developments in advanced antimicrobial nanotechnologies provide numerous opportunities to effective remove resistant bacteria and prevent resistance from occurring through unique mechanisms.With tunable physicochemical properties,nanomaterials can be designed to be bactericidal,antifouling,immunomodulating,and capable of delivering antibacterial compounds to the infection region with spatiotemporal accuracy.Despite its substantial advancement,an important,but under-explored area,is potential microbial resistance to nanomaterials and how this can impact the clinical use of antimicrobial nanotechnologies.This review aims to provide a better understanding of nanomaterial-associated microbial resistance to accelerate bench-to-bedside translations of emerging nanotechnologies for effective control of implant associated infections. | Zhuoran Wu Brian Chan Jessalyn Low Justin Jang Hann Chu Hwee Weng Dennis Hey Andy Tay | 2022 | Bioactive Materials2022，7，10： | 1 |
| 11 | Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis显示文摘 | Lai-Shan Tam Brian Tomlinson Tanya T. Chu Tena K. Li Edmund K. Li | 2007 | Clinical Rheumatology2007，，9： | 1 |
| 12 | Surgical Management of Hepatic Neuroendocrine Tumor Metastasis: Results from an International Multi-Institutional Analysis显示文摘 | Skye C. Mayo Mechteld C. Jong Carlo Pulitano Brian M. Clary Srinevas K. Reddy T. Clark Gamblin Scott A. Celinksi David A. Kooby Charles A. Staley Jayme B. Stokes Carrie K. Chu Alessandro Ferrero Richard D. Schulick Michael A. Choti Giles Mentha Jennifer S | 2010 | Annals of Surgical Oncology2010，，12： | 1 |
| 13 | Cellular protein kinase C isozyme regulation by exogenously delivered physiological disulfides-implications of oxidative protein kinase C regulation to cancer prevention显示文摘 | Chu F Chen LH O'Brian CA | 2004 | Carcinogenesis2004，25，4： | 1 |
| 14 | Dynamic Hepatitis C Virus Genotypic and Phenotypic Changes in Patients Treated With the Protease Inhibitor Telaprevir显示文摘 | Christoph Sarrazin Tara L. Kieffer Doug Bartels Brian Hanzelka Ute Müh Martin Welker Dennis Wincheringer Yi Zhou Hui–May Chu Chao Lin Christine Weegink Henk Reesink Stefan Zeuzem Ann D. Kwong | 2007 | Gastroenterology2007，，5： | 1 |
| 15 | 简化三相BLDC电机控制和驱动系统的策略显示文摘高度集成的半导体产品不仅是消费类产品的潮流,同时也逐步渗透至电机控制应用。与此同时,无刷直流(BLDC)电机在汽车和医疗应用等众多市场中也呈现出相同态势,其所占市场份额正逐渐超过其他各类电机。随着对BLDC电机需求的不断增长以及相关电机技术的日渐成熟,BLDC电机控制系统的开发策略已逐渐从分立式电路发展成三个不同的类别。这三类主要方案划分为片上系统(SoC)、应用特定的标准产品(ASSP)和双芯片解决方案。每种策略都有其各自的优缺点。本文将论述这三种方案及其如何在设计的集成度和灵活性之间做出权衡。 | Brian Chu | 2014 | 电子产品世界2014，21，9： | 1 |
| 16 | Estrogen-related genes and their contribution to racial differences in breast cancer risk显示文摘 | Kerryn Reding Chu Chen Kimberly Lowe David Doody Christopher Carlson Christina Chen John Houck Linda Weiss Polly Marchbanks Leslie Bernstein Robert Spirtas Jill McDonald Brian Strom Ronald Burkman Michael Simon Jonathan Liff Janet Daling Kathleen Malone | 2012 | Cancer Causes & Control2012，，5： | 1 |
| 17 | 电池供电应用的集成电路显示文摘目前,不仅是便携式娱乐设备和手持产品采用电池供电应用,此类应用在绿色产品中也有用武之地,例如光伏(PhotoVoltaic,PV)应用和电动车(Electrical Vehicle,EV)等。随着电池在人们的日常生活中日益普及,选择何种电池和低功耗设计方案,已成为电池供电产品的开发能否取得成功的关键。 | Brian Chu | 2011 | 世界电子元器件2011，，3： | 1 |
| 18 | Trust management for Web applications显示文摘 | Yang-Hua Chu Joan Feigenbaum Brian Lamacchia PaulResnick and Martin Strauss | 1997 | Computer Networks and ISDN System1997，29，813： | 1 |
| 19 | Determination of relative assay response factors for toxic chlorinated and brominated dioxins/furans using an enzyme immunoassay (EIA) and a chemically-activated luciferase gene expression cell bioassay (CALUX)显示文摘 | Fatin Samara Brian K. Gullett Robert O. Harrison Andrew Chu George C. Clark | 2008 | Environment International2008，，3： | 1 |
| 20 | 季节性干旱驱动亚热带森林的碳积累显示文摘本研究旨在表明处于南亚热带的鼎湖山生物圈保护区的干旱频率和强度正在增加,并说明季节性干旱对亚热带森林碳积累的影响。这是为了应对全球气候变化导致的干旱加剧所带来的威胁开展的一项研究。我们使干旱指数(标准化降水指数、标准降水蒸散发指数、降水距平百分率及自校准帕尔默干旱指数)准确确定干旱期和降水量增加期。此后,将2003至2014年(12年)监测采集的实测涡动通量和土壤含水量数据在干旱期和湿润期之间进行比较,以确定干旱对生态系统碳积累的影响。在本研究所选择的12年期间,干旱的发生时间约占比20%,最强干旱事件和严重程度发生于2012至2013年。研究期间的年平均降水量和气温分别为1404.57±43.2 mm和22.65±0.1°C,与30年记录(1990–2020)相比较,年降水量减少量可达523 mm,而气温则增加了2.55°C。与全球针对大多数森林生态系统研究所发表的数据呈相反趋势,处于中国南亚热带区域的鼎湖山生物圈保护区在60%的干旱期内所监测的森林生态系统记录到显著的碳积累趋势,说明季节性干旱驱动了森林的碳积累。 | Brian Njoroge Yuelin Li Dennis Otieno Shizhong Liu Simin Wei Ze Meng Qianmei Zhang Deqiang Zhang Juxiu Liu Guowei Chu Fasih Ullah Haider John Tenhunen | 2023 | Journal of Plant Ecology2023，16，1： | 0 |
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