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| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery显示文摘Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration(GBR)and are often made of resorbable collagen or non-resorbable materials such as PTFE.While collagen membranes do not provide sufficient mechanical protection of the covered bone defect,titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery.Thus,biodegradable GBR membranes made of pure magnesium might be an alternative.In this study a biodegradable pure magnesium(99.95%)membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective.After implantation,the magnesium membrane separates the regenerating bone from the overlying,faster proliferating soft tissue.During the initial healing period,the membrane maintained a barrier function and space provision,whilst retaining the positioning of the bone graft material within the defect space.As the magnesium metal corroded,it formed a salty corrosion layer and local gas cavities,both of which extended the functional lifespan of the membrane barrier capabilities.During the resorption of the magnesium metal and magnesium salts,it was observed that the membrane became surrounded and then replaced by new bone.After the membrane had completely resorbed,only healthy tissue remained.The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane.Overall,the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment. | Patrick Rider Zeljka Peric Kacarevic Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Emely Bortel Bernhard Hesse Frank Witte | 2022 | Bioactive Materials2022，7，8： | 7 |
| 3 | Combining extractive heterogeneous-azeotropic distillation and hydrophilic pervaporation for enhanced separation of non-ideal ternary mixtures显示文摘The separation of non-ideal mixtures using distillation can be an extremely complex process and there continues to be a need to further improve these techniques.A new method which combines extractive heterogeneous-azeotropic distillation(EHAD)and hydrophilic pervapora-tion(HPV)for the separation of non-ideal termary mixtures is demonstrated.This improved distillation method combines the benefits of heterogeneous-azeotropic and extractive distillations in one column but no added materials are needed as is usually the case with pervaporation.The separation of water-methanol-ethyl acetate and water-methanol-isopropyl acetate mixtures were investigated to demonstrate the accuracy of the combined EHAD/HPV technique.There is not currently an established treatment strategy for the separation of the second mixtures in the literature.These separation processes were rigorously modelled and optimized using a professional flowsheet.The objective functions were total cost and energy consumption and heat integration was also investigated.The verification of the process modelling was carried out using laboratory-scale measurements.Extractive heterogeneous-distillation combined with methanol dehydration was found to be more efficient than conventional distillation for the separation of these highly non-ideal mixtures. | Eniko Haaz Botond Szilagyi Daniel Fozer Andras Jozsef Toth | 2020 | Frontiers of Chemical Science and Engineering2020，14，5： | 2 |
| 4 | 'The Japanese Order of Things:Notes on Humanism and the Man-Environment Relationship in Japan,'显示文摘 | Botond Bognar | 1988 | Pratt Joumal of Architecture1988，2，1988： | 1 |
| 5 | 'What Goes Up,Must Come Down:Recent Urban Architecture in Japan,'显示文摘 | Botond Bognar | 1997 | Harvard Design Magazine1997，，1997： | 1 |
| 6 | Reinforcement learning in a distributed market-based production control system显示文摘 | Csanad C B Laszlo M Botond K | 2006 | Advanced Engineering Informatics2006，20，3： | 1 |
| 7 | What Goes Up,Must Come Down显示文摘 | Botond Bognar | | 0，，： | 1 |
| 8 | A model of reference-depend- ent preferences 显示文摘 | Botond K(iszegi Matthew Rabin | 2005 | Quarterly Journal of Economics2005，121，4： | 1 |
| 9 | Hierarchy in distributed shop floor control显示文摘 | MONOSTORI L DUNCAN M BOTOND K | 2000 | Computers in Industry2000，43，： | 1 |
| 10 | Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells显示文摘 | Marion Pepper Antonio J. Pagán Botond Z. Igyártó Justin J. Taylor Marc K. Jenkins | 2011 | Immunity2011，，4： | 1 |
| 11 | What Goes Up, Must Come Do- wn显示文摘 | Botond Bognar | 1994 | Harvard Design Magazine1994，，3： | 1 |
| 12 | Hierarchy in distributed shop floor control显示文摘 | Luc Bongaerts Laszlo Monostori Duncan McFarlane Botond Kadar | 2000 | Computers in Industry2000，43，： | 1 |
| 13 | Effect of application frequency and reduced rates of Acibenzolar-S-Methyl on the field efficacy of induced resistance against bacterial spot on tomato显示文摘 | Cheng-Hua Huang Gary E Vallad Shouan Zhang Amin Wen Botond Balogh Jose Francisco L Figueiredo Franklin Behlau Jeffrey B Jones M Timur Momol Steve M Olson | 2012 | Plant Disease2012，96，2： | 1 |
| 14 | Pathological peptide fokling in Alzheimer's disease and other conformational disorders显示文摘 | Peter P Mager Botond Penke Regina Walter | 2002 | Curr Med Chem2002，9，： | 1 |
| 15 | Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism显示文摘 | Nathan E. Welty Christopher Staley Nico Ghilardi Michael J. Sadowsky Botond Z. Igyártó Daniel H. Kaplan | 2013 | Journal of Experimental Medicine2013，，10： | 1 |
| 16 | Stability-oriented evaluation ofrescheduling strategies by using simulation显示文摘 | Andras Pfeiffer Botond Kadar Laszlo Monostori | | 0，，： | 1 |
| 17 | Prolonged Survival Using Anti-CD20 Combined Chemotherapy in Primary Prostatic Intravascular Large B-cell Lymphoma显示文摘 | Judit Csomor Ilona Kaszás Balázs Kollár László Pajor Zsolt Egyházi Sándor Fekete Miklós Egyed Botond Timár | 2008 | Pathology & Oncology Research2008，，3： | 1 |
| 18 | Stability-orien ted Evaluation of Rescheduling Strategies, by Using Simulation 显示文摘 | Andrars P Botond K La:szlor M | 2007 | Computers in Industry2007，58，： | 1 |
| 19 | Ethylene production ACC content PAL and POD activities in excised seetion of straight and bent gerbera scapes显示文摘 | MENCARL L AGOSTLNIR R BOTOND R | 1995 | Journal of Horticultural Science1995，70，3： | 1 |
| 20 | A novel and simple fluorescence method for the measurement of presynaptic vesicular zinc release in acute hippocampal slices with a fluorescence plate reader显示文摘 | ZSOLT L DATKI á KOS HUNYA BOTOND PENKE | 2007 | Brain Res Bull2007，74，13： | 1 |
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