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| 1 | 中国和美国原始土壤中非高温发现和鉴定显示文摘近年来在非极端环境中已经发现有古菌(Archaea)的存在, 但在中国原始土壤中还未见报道。本研究的目的是调查古菌是否存在于两个分别取自中国新疆和广西的土壤及两个美国亚利桑那州南部地区的土壤中。我们分别构建了这四个原始土壤的古菌16S rDNA文库并对28个克隆的16S rDNA进行了鉴定。所有这些16S rDNA的序列都归类于古菌的泉古菌门(Crenarchaeota)。进化树分析表明, 这些泉古菌的16S rDNA属于非高温陆地环境中的泉古菌种群, 明显区别于海洋和淡水地带的泉古菌种群。这个泉古菌种群又有两个分支, 这两个分支在16S rDNA序列上和G+C含量上有明显的区别。本研究在两个中国和两个美国原始土壤中鉴定了非高温泉古菌的存在, 由此证明泉古菌的存在范围不只局限于高温等极端环境。另外, 美国原始土壤中的泉古菌只属于一个进化分支, 这说明非高温泉古菌种群的类型和土壤的地理位置及土壤特性有关。 | 樊昊心 Derek J. Fairley Christopher Rensing Ian L. Pepper 王革娇 | 2006 | 生物多样性2006,14,3: | 7 |
| 2 | 一种新型的高频半导体量子点单电子泵显示文摘除了直流负电压外,还在浅法刻蚀出的GaAs/AlGaAs量子线上的两个金属指形门上分别叠加两个相位相差π的正弦信号,从而对形成量子点的两个势垒作不等幅调制.在无源漏偏压的情况下,通过周期形成的量子点实现了单电子的搬运.由于新的半导体量子点单电子泵不是依赖库仑阻塞效应通过隧穿进行单电子输运,因此,该器件就不会受到固定隧穿时间引起的低工作频率限制.在1.7K温度下,频率达到3GHz仍然可以观测到量子化电流平台,对应的电流值达到0.5nA量级.这种新器件提供了实现高速度、高精度搬运单电子的另一种可能途径. | 李玲 Kaestner B Blumenthal M D Giblin S Janssen T J B M Pepper M Anderson D Jones G Ritchie D A 高洁 | 2008 | 物理学报2008,57,3: | 4 |
| 3 | Current status of clinical islet transplantation显示文摘Islet transplantation(IT) is today a well-established treatment modality for selected patients with type 1 diabetes mellitus(T1DM). After the success of the University of Alberta group with a modified approach to the immune protection of islets, the international experience grew along with the numbers of transplants in highly specialized centers. Yet, long-term analysis of those initial results from the Edmonton group indicated that insulin-independence was not durable and most patients return to modest amounts of insulin around the fifth year, without recurrent hypoglycemia events. Many phenomena have been identified as limiting factor for the islet engraftment and survival, and today all efforts are aimed to improve the quality of islets and their engrafting process, as well as more optimized immunosuppression to facilitate tolerance and ultimately, better long term survival. This brief overview presents recent progress in IT. A concise historical perspective is provided, along with the latest efforts to improve islet engraftment, immune protection and ultimately, prolonged graft survival. It is apparent that as the community continues to work together further optimizing IT, it is hopeful a cure for T1 DM will soon be achievable. | Andrew R Pepper Boris Gala-Lopez Oliver Ziff AM James Shapiro | 2013 | World Journal of Transplantation2013,3,4: | 3 |
| 4 | Genistein a dietary-derived inhibitor of in vitro angiogenesis显示文摘 | Fotsis T Pepper M Adlercreutz H | 1993 | Proc Natl Acad Sci USA1993,90,7: | 2 |
| 5 | Genistein,a dietary ingested isoflavonoid,inhibits cell proliferation and in vitro angiogenesis显示文摘 | Fotsis T Pepper M Adlercreutz H | 1995 | J Nutr1995,125,3: | 1 |
| 6 | Do you want to keep your customers forever显示文摘 | Pine BJ Peppers D Roggers M | 1995 | Harvard Business Review1995,73,2: | 1 |
| 7 | Simple kinetic models of petroleum formatien(part Ⅲ:Modeling an open system)显示文摘 | Pepper A Corvi P | 1995 | Marine and Petroleum Geology1995,12,4: | 1 |
| 8 | Lymphangiogenesis and tumor metastasis显示文摘 | Tille JC Nisato R | 2003 | Cell Tissue Res2003,314,1: | 1 |
| 9 | Mesenchymal cells potentiate vascular endothelial growth factor-induced angiogenesis in vitro 显示文摘 | Tille JC Pepper MS | 2002 | Exp Cell Res2002,280,: | 1 |
| 10 | Endothelial cell integrin α5β1 expressionis modulated by eytokines and during migration in vitro 显示文摘 | Collo G Pepper GS | 1999 | J Cell Science1999,11,: | 1 |
| 11 | Leukemia inhibitory factor (LIF) inhibits angiogenesis in vitro显示文摘 | Pepper MS Ferrara N Orci L | 1995 | J Cell Sci1995,108,1: | 1 |
| 12 | Simple kinetic models of petroleum formation显示文摘 | Pepper A S Corvi P J | 1995 | Marine and Petroleum Geology1995,12,: | 1 |
| 13 | The histology of viable and ibernating myocardium in relation to imaging characteristics显示文摘 | Gunning MG Kaprielian RR Pepper J | 2002 | JAm Coll Cardiol2002,39,3: | 1 |
| 14 | Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells显示文摘 | Olofsson B Korpelainen E Pepper MS Mandriota SJ Aase K Kumar V | 1998 | Proc Natl Acad Sci USA1998,95,11: | 1 |
| 15 | Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells显示文摘 | Olofsson B Korpelainen E Pepper MS | | 0,,: | 1 |
| 16 | Microbial responses to environmentally toxic cadmium显示文摘 | Roane T M Pepper I L | 1999 | Microbial Ecology1999,38,4: | 1 |
| 17 | Plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines 显示文摘 | Bochaton-Piallat M-L Gabbiani G Pepper MS | 1998 | Circ Res1998,82,10: | 1 |
| 18 | Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro 显示文摘 | Ferrara N Orci L | 1992 | Biochem Biophys Res Commun1992,189,: | 1 |
| 19 | Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3显示文摘 | Apte BA Pepper MS Voest E Montesano R Olsen B Murphy G | 1997 | Invest Ophthalmol Vis Sci1997,38,: | 1 |
| 20 | Vascular endothelial growth factor-induced in vitro angiogenesis and plasminogen activator expression are dependent on endogenojus basic fibroblast growth factor显示文摘 | Mandriota SJ Pepper MS | 1997 | J Cell Sci1997,110,: | 1 |