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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | 【特刊综述】睾酮和雌二醇检测方法面临的挑战和取得的进展显示文摘在患者护理、公共卫生、科学研究过程中类固醇激素的检测方法需要正确而精准,因为这些检测的标准可以保证所有的临床机构和研究机构的结果具有可比性。本文陈述了目前有关检验结果易变的主要问题以及最近美国疾病预防控制中心(CDc)针对提升检验效果所做的工作。目前,睾酮和雌二醇的检测方法还无法达到高度的正确性和精准性。虽然类固醇激素检测方法已经有了长足的进步,但是实验室内部和实验室之间的检测差异仍然未能得到相应的改善。检测标准和特异性的差异被认为是测量精度变异性的来源。最终认为,类固醇激素检测的不准确性似乎是由综合因素造成的,其中不一致的检验标准和缺乏特异性被认为是产生结果变异的两个主要因素。目前,同一批次内的化验结果也变异较大,特别是在样本浓度低的情况下。2007至2011年间的质谱分析法和CDC参考方法之间的平均绝对偏差下降了50%,由此可以看出CDC激素标准化测试程序正在提高临床化验的准确性。这种测试程序可以为CDC参考方法提供追朔源头的途径,从而减少产生测量结果变异的因素。 | Hubert W Vesper Julianne C Botelho Yuesong Wang | 2014 | Asian Journal of Andrology2014，16，2： | 3 |
| 3 | The Diffusion of Cellular Phones in Portugal显示文摘 | Botelho A Pinto L C | 2004 | Telecommunications Policy2004，，28： | 1 |
| 4 | Use of Autologous Mesenchymal Stem Cells Derived from Bone Marrow for the Treatment of Naturally Injured Spinal Cord in Dogs显示文摘 | Euler Moraes Penha Cássio Santana Meira Elisalva Teixeira Guimar?es Marcus Vinícius Pinheiro Mendon?a Faye Alice Gravely Cláudia Maria Bahia Pinheiro Taiana Maria Bahia Pinheiro Stella Maria Barrouin-Melo Ricardo Ribeiro-dos-Santos Milena Botelho Pereira | 2014 | Stem Cells International2014，，： | 1 |
| 5 | Psyllium as a substitute for gluten in bread显示文摘 | ZANDONADI R P BOTELHO R B A ARAUJO W M C | 2009 | Journal of the American Dietetic Association2009，109，10： | 1 |
| 6 | l)oppler ul trasound: a powerful tool for vascular access surveiI lance显示文摘 | Guedes Marques M Ibeas J Botelho C | 2015 | Semin Dial2015，28，2： | 1 |
| 7 | Syner-gism on antioxidant activity between natural compounds optimized byresponse surface methodology显示文摘 | CAPITANI C D CARVALHO A C L BOTELHO P B | 2009 | European Journal of Lipid Science andTechnology2009，111，11： | 1 |
| 8 | Partial oxidation of methane over bimetallic nickel-lanthanide oxides显示文摘 | Ferreira A C Ferraria A M Botelho do Rego A M Goncalves A P Correia M R Gasche T A Branco J B | | 0，，01： | 1 |
| 9 | Viscoelastic behavior of multiwalled carbon nanotubes into phenolic resin显示文摘 | Botelho E C Costa M L | 2013 | Materials Research2013，16，4： | 1 |
| 10 | Effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture 显示文摘 | BOTELHO A P SANTOS-ZAGO L F OLIVEIRA A C | 2009 | Brazilian Journal of Nutrition2009，22，5： | 1 |
| 11 | Influence of cassava starch content and sintering temperature on the alumina consolidation technique 显示文摘 | Almeida F A Botelho E C Melo F C L | 2009 | Journal of the European Ceramic Society2009，29，： | 1 |
| 12 | Methylene blue adsorption by algal biomass based materials:Biosorbents characterization and process behaviour显示文摘 | Vilar V J P Botelho C Boaventura R A R | 2007 | Journal of Hazardous Materials2007，147，1： | 1 |
| 13 | Fatigue behaviour study on repaired aramid fiber/epoxy compos- ites显示文摘 | Botelho E C Mazur R L Costa M L | 2009 | Journal of Aerospace Technology & Management2009，1，2： | 1 |
| 14 | Equilibrium and kinetic modeling of Cd ( II ) biosorption by algae Gelid- ium and agar extraction algal waste 显示文摘 | Vilar V I P Botelho C M S Boaventura R A R | 2006 | Water Research2006，40，3： | 1 |
| 15 | Reproductive effects of di(2-ethylhexyl) phthalate in immature male rats and its relation to cholesterol testosterone, and thyroxin levels 显示文摘 | Botelho G G Golin M Bufalo A C | 2009 | Archives of Environmental Contamination and Toxicology2009，57，4： | 1 |
| 16 | A review of the use of red mud as adsorbent for the removal of toxic pollutants from water and wastewater显示文摘 | Bhatnagar A Vilar V J Botelho C M | 2011 | Environ Techn2011，32，34： | 1 |
| 17 | Mechanical behav- ior of carbon fiber reinforced polyamide composites显示文摘 | Botelho E C Figiela L Rezendeb M C | 2003 | Compos- ites Science and Technology2003，63，： | 1 |
| 18 | Damping behavior of continuous fiber/metal composite materials by the free vibration method显示文摘 | BOTELHO E C CAMPOS A N D BARROS E | 2006 | Composites: Part B2006，37，： | 1 |
| 19 | Equilibrium and kinetic modeling of Cd (Ⅱ) biosorption by algae Gelidium and agar extraction algal waste 显示文摘 | Vilar V I P Botelho C M S Boavcntura R A R | 2006 | Water Research2006，40，3： | 1 |
| 20 | Mechanical behavior of carbon fiber reinforced polyamide composites 显示文摘 | BOTELHO E C FIGIEL L REZENDE M C | 2003 | Composites Science and Technology2003，，63： | 1 |
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