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| 1 | 子宫内膜异位症妇女月经期腹膜及子宫内膜生物学相关细胞因子和生长因子的基因表达增加显示文摘Objective: To examine differential messenger RNA(mRNA)-expression of relevant cytokines, metalloproteases, growth and adhesion factors in endometrium and peritoneum from women with endometriosis when compared with women without the disease duringmenstrual and luteal phases of the cycle. Design: Patients with endometriosis were compared with control patients. Setting: University hospital. Patient(s): A total of 35 patients(20 patients during the luteal phase and 15 patients during the menstrual phase)were selected for this study on the basis of cycle phase and presence or absence of endometriosis. Intervention( s): In this study, endometriosis was laparoscopically and histologically confirmed in 24 women with endometriosis of revised American Society for Reproductive Medicine(ASRM) stage I-II(n=12) and revised ASRM stage III-IV(n=12), and the presence of a normal pelvis was documented by laparoscopy in 11 control patients. The macroscopically normal peritoneum tissues were collected from lateral wall left or right, near the colon ascendens or descendens. Main Outcome Measure(s): The expression levels were determined as ratios between the target molecules and β-actin as housekeeping gene. Result(s): In women with endometriosis, peritoneal mRNA levels of matrix metalloproteinase(MMP)-3, transforming growth factor-β, interleukin(IL)-6, and intercellular adhesion molecule-1 and endometrial mRNA levels of MMP-3, tumor necrosis factor(TNF)-α, and IL-8 were significantly higher during the menstrual phase when compared with luteal phase. During the menstrual phase of the cycle, both endometrial expression of TNF-α, IL-8, and MMP-3 mRNA levels and peritoneal expression of transforming growth factor-β, IL-6, and intercellular adhesion molecule-1 mRNA levels were significantly higher in women with endometriosis when compared with controls. Immunohistochemical staining confirmed the presence of TNF-αin peritoneum and endometrium in both women with endometriosis and controls. Conclusion(s): Increased endometrial and peritoneal cytokine mRNA expression during menstruation may contribute to a pelvic inflammatory microenvironment favoring the development of endometriosis. | Kyama C.M. Overbergh L. Debrock S. T.M. D'Hghe 党慧敏 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，10： | 2 |
| 2 | Growth hormone secretagogue bidning sites in peripheral human tissues显示文摘 | Papotti M Ghe C Cassoni P | 2000 | J Clin Endocrinol Metab2000，85，10： | 1 |
| 3 | Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines显示文摘 | Cassoni P Ghe C Marrocco T | 2004 | Eur J Endocrinol2004，150，： | 1 |
| 4 | Intensive insulin therapy in the critically ill patients显示文摘 | van den Ber ghe G Wouters P Weekers F et a1 | 2001 | N Engl J Med2001，345，19： | 1 |
| 5 | Evidence for Cammacerane as an Indicator of Water Column Stratification 显示文摘 | Sinnin ghe Damste J S Kenig F Koopmans | 1995 | Geochim Cosmchim Acta1995，59，9： | 1 |
| 6 | The anti-proliferative effect of synthetic peptidyl GH secretagogues in human CALU-1 lung carcinoma cells显示文摘 | Ghe C Cassoni P Catapano F | 2002 | Endocrinology2002，143，： | 1 |
| 7 | Nuclear medicine and infection detection:the relative effectiveness of imaging with 111 in-orine-,99 Tcm-HMPAO-,and 99Tcm-stannous fluoride colloid labeled leukocytes and with 67Gacit rate显示文摘 | HU GHES DK | 2003 | Nucl Med Technol2003，31，4： | 1 |
| 8 | Stability measure- ments of osseointegrated implants using Osstell in partially edentulous jaws after 1 year of loading: a pilot study 显示文摘 | Balle ri P Cozzolino A Ghe lli L | 2002 | Clin Implant Dent Relat Res2002，4，3： | 1 |
| 9 | Growth hormone secretagogue binding sites in peripheral human tissues显示文摘 | Papotti M Ghe C Cassoni P | 2000 | J Clin Endocrinol Metab2000，85，： | 1 |
| 10 | Amperometric glucose biosensor based on Prussian blue-multiwall carbon nano- tubes composite and hollow PtCo nanochains 显示文摘 | Ghe X Yuan R Chai Y Q | 2010 | Electro- chim Acta2010，19，： | 1 |
| 11 | Connexin expression and gap junctional intercellular communication in human squamous ceil carcinoma of the head and neck显示文摘 | FRAN K DK SZYMKOWIA KB HU GHES CA | 2006 | Otolaryngol Head Neck Surg2006，135，5： | 1 |
| 12 | Growth hormone secretag ogue binding sites in peripheral human tissues显示文摘 | Papotti M Ghe C Cassoni P | 2000 | J Clin Endocrinol Metab2000，85，： | 1 |
| 13 | Identification,characterization,and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines显示文摘 | Cassoni P Papotti M Ghe C | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 14 | Growth hormone secretagogue binding sites in peripheral human tissues 显示文摘 | Papotti M Ghe C Cassoni P | 2000 | J Clin Endocrinol Metab2000，85，10： | 1 |
| 15 | The anti-proliferative effect of synthetic peptidyl GH secretagogues in human CALU-1 lung carcinoma cells显示文摘 | Ghe C Cassoni P Catapano F | 2002 | Endocrinology2002，143，： | 1 |
| 16 | High expression of capsid protein of red‐spotted grouper nervous necrosis virus in an avian cell line requires viral RNA2 non‐coding regions显示文摘 | J NHuang LLin S PWeng J GHe | 2007 | Journal of Fish Diseases2007，，7： | 1 |
| 17 | Growth hormone secretagogues binding sites in peripheral human tissues显示文摘 | Ghe C Cassoni P | 2001 | Clin Endocrinol Metab2001，85，： | 1 |
| 18 | Rotavirus infection in commercial laying hens显示文摘 | Jones R C Hμghes C S Henry R R | 1979 | Vet Rec1979，104，1： | 1 |
| 19 | Identification, characterization,and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines 显示文摘 | Cassoni P Papotti M Ghe C | 2001 | J Clin Endocrinol Metab2001，86，4： | 1 |
| 20 | Laparoscopic choledochoscopy显示文摘 | L Alecu A Marin Ghe Corodeanu L Gulinescu | 2003 | Chirurgia2003，98，2： | 1 |
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