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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | An in situ grown eutectic magnetoelectric composite material-1: Composition and unidirectional solidification 显示文摘 | Van den Boomgaard J Terrell D Born R A J Giller H F J I | 1974 | Journal of Materials Science1974，9，： | 1 |
| 3 | Aggregation of bloodplatelets by adenosine diphosphate and its reversal显示文摘 | Born G V R | 1962 | Nature1962，194，： | 1 |
| 4 | Increased matrix metallopmteinase-8and-9 activity in patients with infarct Rupture after myocardial infarction显示文摘 | Van den Borne S W Cleutjens J P Hanemaaijer R | 2009 | Cardiovasc Pathol2009，18，1： | 1 |
| 5 | An in situ grown eutectic magnetoelectric composite material显示文摘 | Boomgaard J Terrell D R Born R A J | 1974 | J Mater Sci1974，9，： | 1 |
| 6 | Plasma separation and bilirubin adsorption after complicated liver transplantation:a therapeutic approach to excessive hyperbilirubinemia显示文摘 | Ott R Rupprecht H Born G | 1998 | Transplantation1998，65，3： | 1 |
| 7 | A sintered magnetoelectric composite material BaTiO3 -Ni( Co, Mn) Fe2O4显示文摘 | Boomgaard J Born R A J | 1978 | J Mater Sci1978，13，： | 1 |
| 8 | Dynamics of porous saturated media,checking of generalized law of darcy显示文摘 | Auriault J L Borne L Chambon R | 1985 | J Acoust Soc Am1985，77，5： | 1 |
| 9 | Reduced hippocampal glutamate in Alzheimer disease显示文摘 | Rupsingh R Borne M Smith M | 2009 | Neurobiol Aging2009，32，： | 1 |
| 10 | ERCP or EUS for tissue diagnosis of biliary strictures? a prospective comparative study显示文摘 | Thomas R?sch Kim Hofrichter Eckart Frimberger Alexander Meining Peter Born Norbert Weigert Hans-Dieter Allescher Meinhard Classen Marius Barbur Ulrich Schenck Martin Werner | 2004 | Gastrointestinal Endoscopy2004，，3： | 1 |
| 11 | High-resolution typing reveals distinct Chlamydia trachomatis strains in an at- risk population in Nanjing, China 显示文摘 | Born R J van den Hoek A Wang Q | 2013 | Sex Transm Dis2013，40，8： | 1 |
| 12 | Zur Quantentheorie der Mole- keln显示文摘 | BORN M OPPENHEIMER R | 1927 | Annalen Der Physik1927，，20： | 1 |
| 13 | Fly ash mediated reactions ofphenolandmonochlorophenols: oxychlorination, deep oxidation and condensation显示文摘 | BORN J G P MULDER P LOUVV R | 1993 | Environmental Science & Technology1993，27，9： | 1 |
| 14 | Effect of Cheyne-Stokes respiration on muscle sympathetic nerve activity in severe congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy 显示文摘 | van de Borne P Oren R Abouassaly C | 1998 | Am J Cardiol1998，81，4： | 1 |
| 15 | Functional relevance of G-protein-coupled-receptor-associated proteins,exemplified by receptor-activity-modifying proteins(RAMPs)显示文摘 | Muff R Born W | 2002 | Biochem Soc Trans2002，30，4： | 1 |
| 16 | Aggregation of blood platelets by adenosine diphosphate and its reversal显示文摘 | Born G V R | 1962 | Nature1962，194，： | 1 |
| 17 | Biomimetic coatings functionalized with adhesion peptides for denta implants显示文摘 | Roessler S Born R Scharnweber D | 2001 | J Mater Sci Mater Med2001，12，1012： | 1 |
| 18 | Empirical orthogonal function analysis of global TOPEX/POSEIDON altimeter data and implications for detection of global sea level rise显示文摘 | Hendricks J R Leben R R Born G H | 1996 | Journal of Geophysical Research1996，101，14： | 1 |
| 19 | Determining the potential global distribution of natural vegetation,crops and agricultural productivity显示文摘 | Leemans R Van den Born G J | 1994 | Water Air and Soil Pollution1994，76，： | 1 |
| 20 | Increased matrix metalloproteinase-8 and -9 activity in patients with infarct rupture after myocardial infarction 显示文摘 | van den Borne SW Cleutjens JP Hanemaaijer R | 2009 | Cardiovasc Pathol2009，18，1： | 1 |
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