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| 1 | Sex-influenced association of nonalcoholic fatty liver disease with coronary heart disease显示文摘 | Mary F. Feitosa Alexander P. Reiner Mary K. Wojczynski Mariaelisa Graff Kari E. North Jeffrey J. Carr Ingrid B. Borecki | 2013 | Atherosclerosis2013，，： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | A snapshot on spatial and vertical distribution of bacterial communities in the eastern Indian Ocean显示文摘Besides being critical components of marine food web,microorganisms play vital roles in biogeochemical cycling of nutrients and elements in the ocean.Currently little is known about microbial population structure and their distributions in the eastern Indian Ocean.In this study,we applied molecular approaches including polymerase chain reaction-denaturant gradient gel electrophoresis(PCR-DGGE) and High-Throughput next generation sequencing to investigate bacterial 16S rRNA genes from the equatorial regions and the adjacent Bay of Bengal in the eastern Indian Ocean.In general,Bacteroidetes,Proteobacteria(mainly Alpha,and Gamma),Actinobacteria,Cyanobacteria and Planctomycetes dominated the microbial communities.Horizontally distinct spatial distribution of major microbial groups was observed from PCR-DGGE gel image analyses.However,further detailed characterization of community structures by pyrosequencing suggested a more pronounced stratified distribution pattern:Cyanobacteria and Actinobacteria were more predominant at surface water(25m);Bacteroidetes dominated at 25m and 150m while Proteobacteria(mainly Alphaproteobacteria) occurred more frequently at 75m water depth.With increasing water depth,the bacterial communities from different locations tended to share high similarity,indicating a niche partitioning for minor groups of bacteria recovered with high throughput sequencing approaches.This study provided the first 'snapshot' on biodiversity and spatial distribution of Bacteria in water columns in the eastern Indian Ocean,and the findings further emphasized the potential functional roles of these microbes in energy and resource cycling in the eastern Indian Ocean. | WANG Jing KAN Jinjun BORECKI Laura ZHANG Xiaodong WANG Dongxiao SUN Jun | 2016 | Acta Oceanologica Sinica2016，35，6： | 2 |
| 4 | The frequency and effects of Cytoehrome P450 (CYP)2C9 polymorphisms in patients receiving warfarin 显示文摘 | Tabrizi AR Zehnbauer BA Borecki IB | 2002 | Joumal of the American College of Surgeons2002，194，： | 1 |
| 5 | HLA-Cw group 1 ligands for KIR increase susceptibility to invasive cervical cancer 显示文摘 | Martin MP Borecki IB Zhang ZY | 2010 | Immunogenetics2010，62，1112： | 1 |
| 6 | Associations between the Leptin receptor gene and adiposity in mid dle-aged Caucasian males from the HERITAGE family stud显示文摘 | Chagnon Y C Wilmore J H Borecki J B | 2000 | Journal of Clinical Endocrinology and Metab- olism2000，85，1： | 1 |
| 7 | Ca&2+ - activated K^+ channel of the BK - type in the inner mitochondrial membrane of a hu- man glioma cell line显示文摘 | Siemen D Loupatatzis C Borecky J | 1999 | Biochem Biophys Res Commun1999，257，2： | 1 |
| 8 | Plant uncoupling mitochon-dria proteins显示文摘 | Vercesi A E Borecky J Maia I G | 2006 | Annu Rev Plant Biol2006，57，： | 1 |
| 9 | Segregation analysis of serum uric acid in the NHLBI Family Heart Study 显示文摘 | Wilk JB Djousse k Borecki I | 2000 | Hum Genet2000，106，3： | 1 |
| 10 | Inheritance of the waist-to-hip ratio in the national heart, lung, and blood institute family heart study 显示文摘 | FEITOSA M F BORECKI I STEVEN C | 2000 | Obesity Research2000，8，： | 1 |
| 11 | Relationship between tracheostomy timing and duration of mechanical ventilation in critically ill patients显示文摘 | FREEMAN B D BORECKI I B COOPERSMITH C M | 2005 | Crit Care Med2005，33，11： | 1 |
| 12 | Relationship between tracheostomy timing and duration of mechanical ventilation in critically ill patients显示文摘 | Freeman BD Borecki IB Coopersmith CM | 2005 | Crit Care Med2005，33，11： | 1 |
| 13 | Associations between theleptin receptor gene and adiposity in middle aged Caucasianmales from the heritage family study 显示文摘 | Wilmore JH Borecki IB | 2000 | J Clin EndocrionlMetab2000，85，1： | 1 |
| 14 | The frequency and effects of cytochrome P450 (CYP)2C9 polymorphisms in patientsreceiving warfarin显示文摘 | Zehnbauer BA Borecki IB | 2002 | J Am Coll Surg2002，194，3： | 1 |
| 15 | Plant uncoupling mitochondrial protein and alternative oxidase:Energy metabolism and stress显示文摘 | Borecky J Vercesi AE 2005 | 2005 | Bioscience Reports2005，，34： | 1 |
| 16 | Smoking, inflammatory patterns and postprandial hypertriglyceridemia显示文摘 | Edmond K. Kabagambe Jose M. Ordovas Michael Y. Tsai Ingrid B. Borecki Paul N. Hopkins Stephen P. Glasser Donna K. Arnett | 2008 | Atherosclerosis2008，，2： | 1 |
| 17 | The Na(+)-K(+)- ATPase alpha2 geneand trainability of eardiorespiratory endurance: the HERITAGE family study 显示文摘 | Rankinen T Perusse L Borecki I | 2000 | J Appl Physiol2000，88，1： | 1 |
| 18 | Relationship between tracheostomy timing and duration of mechanical ventilation in critically ill patients显示文摘 | Freeman BD Borecki IB Coopersmith CM | | 0，，： | 1 |
| 19 | Relationship between tracheostomy timing and duration of mechanical ventilation in critically ill patients显示文摘 | Freeman BD Borecki IB Coopersmith CM | | 0，，11： | 1 |
| 20 | Angiote- nsinogen and angiotensin converting enzyme genotypes and carotid atherosclerosis: the atherosclerosis risk in commu- nities and the NHLBI family heart studies显示文摘 | ARNETr DK BORECKI IB LNDWIG EH | 1995 | Atherosclero- sis1995，138，1： | 1 |
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