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您的检索式：作者名="Michael Schemann"
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| 1 | Therapy-refractory gastrointestinal motility disorder in a child with c-kit mutations显示文摘Constipation and fecal impaction are frequent and distressing complaints in pediatric gastroenterology. Especially in neurologically handicapped children, treatment of severe forms of slow-transit constipation (STC) can be difficult. In the majority of cases, STC is of unknown etiology. However, in recent years, there is growing evidence that interstitial cells of Cajal (ICCs), which serve as electrical pacemakers and generate spontaneous electrical slow waves in the gastrointestinal tract, might play an important role in the pathophysiology of STC. It remains unclear whether morphological ICC alterations seen in affected patients are based on congenital developmental anomalies, or whether they are a consequence of long-term constipation with secondary damage of the gastrointestinal nervous system. To the best of our knowledge, we present the first case of a patient with histological alterations in ICC morphology who displayed multiple alterations of c-kit at the level of mRNA. The protein encoded by c-kit is the receptor tyrosine kinase Kit (CD117), which is crucial for development and function of ICCs. Therefore, these findings provide a new explanation for congenital alterations of ICC development that result in gastrointestinal motility disorders. | Christian Breuer Jun Oh Gerhard J Molderings Michael Schemann Birgit Kuch Ertan Mayatepek Rüdiger Adam | 2010 | World Journal of Gastroenterology2010，16，34： | 7 |
| 2 | Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation显示文摘 | Natalie Steck Micha Hoffmann Irina G. Sava Sandra C. Kim Hannes Hahne Susan L. Tonkonogy Katrin Mair Dagmar Krueger Mihaela Pruteanu Fergus Shanahan Roger Vogelmann Michael Schemann Bernhard Kuster R. Balfor Sartor Dirk Haller | 2011 | Gastroenterology2011，，3： | 2 |
| 3 | Projections and neurochemical coding of motor neurones to the circular and longitudinal muscle of the guinea pig gastric corpus显示文摘 | Klaus Michel Dania Reiche Michael Schemann | 2000 | Pflügers Archiv - European Journal of Physiology2000，，3： | 1 |
| 4 | Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation显示文摘 | Natalie Steck Micha Hoffmann Irina G. Sava Sandra C. Kim Hannes Hahne Susan L. Tonkonogy Katrin Mair Dagmar Krueger Mihaela Pruteanu Fergus Shanahan Roger Vogelmann Michael Schemann Bernhard Kuster R. Balfor Sartor Dirk Haller | 2011 | Gastroenterology2011，，3： | 1 |
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