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| 1 | Optimization model and algorithm for mixed traffic of urban road network with flow interference显示文摘In this paper,the problem of interferences between motors and non-motors in urban road mixed traffic network is considered and the corresponding link impedance function is presented based on travel demand.On the base of this,the main factors that influence travelers' traffic choices are all considered and a combined model including flow-split and assignment problem is proposed.Then a bilevel model with its algorithm for system optimization of urban road mixed traffic network is proposed.Finally the application of the model and its algorithm is illus-trated with a numerical example. | SI BingFeng,LONG JianCeng & GAO ZiYou State Key Laboratory of Rail Traffic Control and Safety,Beijing Jiaotong University,Beijing 100044,China | 2008 | Science China(Technological Sciences)2008，51，12： | 13 |
| 2 | Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4显示文摘补充 32 的反应基因(RGC-32 ) 是涉及房间的增长,区别和迁居的一个房间周期管理者并且也在 angiogenesis 被含有。这里,我们证明在巨噬细胞的那 RGC-32 表情被 IL-4 导致并且由 LPS 减少了,显示在 RGC-32 表示和 M2 极化之间的一个连接。我们证明 RGC-32 的增加的表示或者激活的巨噬细胞,这蛋白质在压制支持 inflammatory cytokine IL-6 的生产并且支持反煽动性的调停人 TGF-β 的生产是特征的;。与一致在 vitro,数据, RGC-32 高级的联系肿瘤的巨噬细胞(TAM ) 快车,和这个表达式被导出肿瘤的腹水的液体以一种 M-CSF- 或 IL-4-dependent 方式导致。一起,这些结果为 M2 巨噬细胞极化作为一个标记建立 RGC-32 并且显示这蛋白质是为癌症免疫疗法的一个潜在的目标,指向联系肿瘤的巨噬细胞。 | Peng Zhao Daiqing Gao Qingjie Wang Bingfeng Song Qianqian Shao Jintang Sun Chunyan Ji Xingang Li Peng Li Xun Qu | 2015 | Cellular & Molecular Immunology2015，12，6： | 12 |
| 3 | MiR-375 suppresses invasion and metastasis by direct targeting of SHOX2 in esophageal squamous cell carcinoma显示文摘食道的有鳞的房间癌(ESCC ) 是在中国的最普通的组织学的类型。MicroRNAs 内长地在哺乳动物被表示并且由指向潜在的下游的基因在肿瘤侵略和转移起一个重要作用。在现在的学习, microarray 分析证明那 miR-375 表情是显然在 ESCC 的 downregulated 与那相比在正常食道的上皮纸巾。然后,酶记者试金证明 SHOX2 是 miR-375 的直接下游的目标,这个相互作用被营救实验证实。量的聚合酶链反应结果也证明那 SHOX2 表情是在 ESCC 房间和纸巾的 upregulated。进一步的分析证明 SHOX2 在 vivo 并且在 vitro 导致了 ESCC 的增长,侵略,和转移。而且,在 miR-375 和 SHOX2 之间的相互作用影响了 epithelial-to-mesenchymal 转变。我们断定 miR-375 可以由直接指向 SHOX2 压制 ESCC 的侵略和转移。miR-375/SHOX2 轴可以是为 ESCC 的一个新奇治疗学的目标。 | Jun Yi Li Jin Jing Chen BingFeng Zhenyue He Longbang Chen Haizhu Song | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 11 |
| 4 | URBAN TRANSIT ASSIGNMENT MODEL BASED ON AUGMENTED NETWORK WITH IN-VEHICLE CONGESTION AND TRANSFER CONGESTION显示文摘This paper presents an augmented network model to represent urban transit system.Through such network model,the urban transit assignment problem can be easily modeled like a generalized traffic network.Simultaneously,the feasible route in such augmented transit network is then defined in accordance with the passengers' behaviors.The passengers' travel costs including walking time,waiting time,in-vehicle time and transfer time are formulated while the congestions at stations and the congestions in transit vehicles are all taken into account.On the base of these,an equilibrium model for urban transit assignment problem is presented and an improved shortest path method based algorithm is also proposed to solve it.Finally,a numerical example is provided to illustrate our approach. | Bingfeng SI Ming ZHONG Xiaobao YANG Ziyou GAO | 2011 | Journal of Systems Science and Systems Engineering2011，20，2： | 8 |
| 5 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 6 | Sensitivity analyses of different vegetations responding to climate change in inland river basin of China显示文摘陆上的生态系统和气候系统是仔细与对方有关。面对了不可避免的全球气候变化,调查陆上的生态系统对气候作出回应是重要的变化。在在中国的干旱、半干旱的区域的内陆河盆,植被从 1998 ~ 2007 对气候变化作出回应的敏感差别在这份报纸被分析。(1 ) 在植被和气候的全球时间空间的分发的差别是明显的。植被变化在这个整个区域显示出细微降级。降级在浓密地生长的区域是更明显的。温度向下给一个将军看有 1.1467 的一个线性趋势系数的趋势。相反地,降水与 0.3896 的一个线性趋势系数显示出一个增加的趋势。(2 ) 关于中央趋势反应,在对降水(NDVI-P ) 作出回应的 NDVI 和对 AI (NDVI-AI ) 作出回应的 NDVI 的空间分发有类似的特征,它与反应让温度(NDVI-T ) 通风的 NDVI 的相反。NDVI-P 和 NDVI-AI 的典型敏感区域主要盖住北适度的干旱大草原和北适度的荒芜的大草原。NDVI-T 典型敏感区域主要盖住北适度的荒芜的大草原。(3 ) 考虑变化振幅反应, NDVI-T 被更低的敏感统治,温暖的适度的灌木状的、 selui 灌木状的、赤裸的极端的典型区域在东方弄干荒芜、北的适度的草地大草原并且适度半灌木状,在北方使乔木的沙漠相形见绌是高反应。(4 ) 在 NDVI-P 和 NDVI-AI 之间的变化振幅回答介绍类似的空间分布。典型敏感区域主要盖住北适度的荒芜的大草原。有 NDVI-T, NDVI-P 和 NDVI-AI 的各种各样的线性变化趋势回答。至于 NDVI-T 和 NDVI-AI,它被半干旱、半潮湿的气候地区的边界效果影响,有他们沿着边阶的线性变化趋势的更少的关联。在另外的区域有更强壮的关联,特别在在北适度的荒芜的大草原的 NDVI-T 和在温暖的适度的灌木状、 selui 灌木状、赤裸、极端、干燥的沙漠的 NDVI-AI。 | Hou Peng Wang Qiao Cao Guangzhen Wang Changzuo Zhan Zhiming Yang Bingfeng | 2012 | Journal of Geographical Sciences2012，22，3： | 7 |
| 7 | Trends in Incidence Rates,Mortality Rates,and Age-Period-Cohort Effects of Cervical Cancer—China,2003–2017显示文摘Introduction:This study reported the trends and analyzed the age-period-cohort effects on the incidence and mortality rates of cervical cancer in China.Methods:The age-standardized incidence rate(ASIR)and mortality rate(ASMR)by Segi’s world standard population were calculated using qualified consecutive data from 22 cancer registries from 2003 to 2017 in China.We performed joinpoint analysis to describe the trends and age-period-cohort analysis to estimate the independent effects of age,period and cohort on trends in incidence and mortality rates of cervical cancer.Results:The ASIR and ASMR for cervical cancer in females over 20 years old increased during 2003−2017.For females<50 years,a decreasing trend in ASIR and a stable trend in ASMR were observed in urban areas after 2009.But the ASIR and ASMR kept increasing in rural areas during the whole period.For females>50 years,the ASIR and ASMR increased both in urban and rural areas.Age-period-cohort analysis showed increasing period effects on cervical cancer incidence and mortality during the whole period.The cohort effects exhibited a downward-upwarddownward pattern for the incidence(1918–1938,1938–1963,1963–1993)and mortality rates(1918–1943,1943–1963,1963–1993)in urban areas,a fluctuating pattern for incidence rate and a continuing downward pattern for mortality rate(1918–1993)in rural areas.Conclusions:The increases in cervical cancer incidence and mortality rates can be mostly explained by period effects.We observed decreases in risk for cervical cancer incidence and mortality in young female generations,which were more obvious in urban areas. | Kexin Sun Rongshou Zheng Lin Lei Siwei Zhang Hongmei Zeng Shaoming Wang Li Li Ru Chen Bingfeng Han Ji Peng Wenqiang Wei Jie He | 2022 | China CDC weekly2022，4，48： | 4 |
| 8 | Study on the rheology of coal-oil slurries during heating at high pressure显示文摘 | Bingfeng Yan | 2017 | International Journal of Coal Science & Technology2017，4，3： | 4 |
| 9 | Car capacity near bus stops with mixed traffic derived by additive-conflict-flows procedure显示文摘To determinate car capacity at bus stops with mixed traffic, a new theoretical approach was developed on the basis of additive-conflict-flows procedure. The procedure was extended from homogeneous traffic flow to mixed traffic flow. The conflicts among cars, buses and bicycles near the stop can be described by the extended procedure. The procedure can be understood more easily than the theory of gap acceptance. Car capacity near the stop is the function of both bus stream and bicycle stream. The proposed model can also analyze the cases of pedestrian effects and limited priority of bicyclists. Numerical results show that the car capacity decreases with the increasing flow rates of other streams. In addition, pedestrian effects and bicyclist's limited priority have negative effects on car capacity near bus stops with mixed traffic flow. | YANG XiaoBao GAO ZiYou SI BingFeng Gao Liang | 2011 | Science China(Technological Sciences)2011，54，3： | 4 |
| 10 | Identification of ssDNA aptamers specific to clinical isolates of Streptococcus mutans strains with different cariogenicity显示文摘链球菌 mutans,一个克积极的容许的厌氧的细菌,被认为是为牙齿的龋的一个主要 etiological 因素。在 thisstudy,从龋活跃、没有龋的个人的牙齿的瓷釉表面的匾为 S 被获得并且栽培。mutans 隔离。形态学检查,生物化学的描述,和聚合酶链反应被执行到识别。mutans。S 的 cariogenicity。从临床的标本孤立的 mutans 种类被测试细菌的 acidogenicity, aciduricity,细胞外的 polysaccharideproduction,和粘附能力评估。最后,减少性的 SELEX (由 exponentialenrichment 的 ligands 的系统的进化) 指向整个未经触动的房间的技术与 highcariogenicity 为对种类特定的 ssDNA aptamers 习惯于屏幕。在九轮减少性的 SELEX 以后,足够的水池丰富是由放射性的 isotopeanalysis 出现被完成。充实的水池随机被克隆并且定序,由联机的 MEME 和 RNA 结构软件 analysisof 列在后面序列。从流动 cytometry 的结果显示了那 aptamers H1, H16, H4, L1, L10,和 H19 能 discriminatehighly cariogenic S。mutans 紧张从糟糕, cariogenic 拉紧。在这些之中, Aptamer H19 与 cariogenic S 有最强壮的有约束力的能力。有 69.45 的一个分离常数的 mutans 紧张 ? 畣慬? 敭档湡獩獭漠 ??? 湡 ? 桴 ? 潰整瑮慩? 敮 ? 桴牥灡略楴? 瑳慲整楧獥潦 ? 桴 ? 牴慥浴湥 ? 景琠楨?湩敦瑣潩 | Wei Cui Jiaojiao Liu Donghua Su Danyang Hu Shuai Hou Tongnan Hu Jiyong Yang Yanping Luo Qing Xi Bingfeng Chu Chenglong Wang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 3 |
| 11 | Equilibrium model and algorithm of urban transit assignment based on augmented network显示文摘The passenger flow assignment problem for the urban transit network is relatively complicated due to the complexity of the network structure and many factors influencing the passengers' route and line choices. In the past three decades, many models have been proposed to solve the passenger flow assignment problem. However, the common-line problem remains challenging in transit flow assignment. In this paper, the characteristics of the urban transit network is analysed and a new technique of augmented network is proposed to represent the urban transit system. The purpose is to eliminate the complex common-line problem when modeling transit passenger flow assignment. Through this augmentation technique, the urban transit system can be represented by an augmented network-it then behaves like a simple network and can be used as a generalized network for traffic assignment or network analysis. This paper presents a user equilibrium model for the urban transit assignment problem based on such a technique. A numerical example is also provided to illustrate the approach. | SI BingFeng ZHONG Ming SUN HuiJun GAO ZiYou | 2009 | Science China(Technological Sciences)2009，52，11： | 3 |
| 12 | Association of telomere length with authentic pluripotency of ES/iPS cells显示文摘Telomerase 和 telomeres 为干细胞的不定的复制是重要的。最近,体的房间的 telomeres 被发现是 reprogrammed 在导致的 pluripotent 干细胞(iPSCs ) 伸长。然而,在在胚胎的干细胞(转换字符) 或 iPSCs 的 vivo 的发展 pluripotency 的 telomeres 的角色直接没被探讨。我们证明有长 telomeres 的转换字符展出真发展 pluripotency,由完全的转换字符小狗以及 germline 能干的怪物的产生证实了在啮齿类动物可得到的最紧的测试。有短 telomeres 的转换字符显示出减少的 teratoma 形成和怪物生产,并且没能产生完全的转换字符小狗。Telomere 长度高度被相关(r > 0.8 ) 与转换字符的发展 pluripotency。短 telomeres 减少 proliferative 率或转换字符的能力,改变与 telomere epigenetics 有关的基因的表示,为 embryogenesis 重要的下面调整基因并且破坏细菌房间区别。而且,有更长的 telomeres 的 iPSCs 与短 telomeres 比那些与更高的效率产生怪物。我们功能的 telomeres 为 ESCs/iPSCs 的发展 pluripotency 是必要的并且建议那 telomere 长度可以提供一个珍贵标记评估干细胞 pluripotency 的数据表演,特别地当紧测试不是可行的时。 | Junjiu Huang Fang Wang Maja Okuka Na Liu Guangzhen Ji Xiaoying Ye Bingfeng Zuo Minshu Li Ping Liang William W Ge John CM Tsibris David L Keefe Lin Liu | 2011 | Cell Research2011，21，5： | 3 |
| 13 | Key technologies for the construction of the Xiluodu high arch dam on the Jinsha River in the development of hydropower in western China显示文摘Hydropower development in China is concentrated in the country's western regions.Among all the rivers in China,the lower course of the Jinsha River contains the richest hydro-energy resource,and therefore,4 mammoth hydropower plants are under construction on this particular section of the river at Wudongde,Baihetan,Xiluodu,and Xiangjiaba.The water-blocking structures of the hydropower facilities at Wudongde,Baihetan and Xiluodu are all arch dams of around 300 m high.In view of changes in the geological conditions at the foundation of the Xiluodu dam on the riverbed after excavation started,the designs of expanding foundation surface excavation and dovetailing the dam body and foundation rock on both upstream and downstream sides were introduced,allowing the arch dam and foundation to fit each other and improving the stress conditions of the dam body and foundation.By dividing the dam body into various concrete sections,the dynamic properties of concrete were adequately adjusted to the distribution of stress in the dam body.In addition,the use of the most optimal concrete material and mixture ratio allowed thermodynamics of concrete to satisfy the requirements of the strength,durability,temperature control and crack prevention of the concrete.Moreover,rigorous temperature control measures were introduced to prevent harmful cracking,thus enhancing the integrity of the arch dam.Furthermore,sophisticated construction machinery,scientific testing methods,and sound construction techniques were employed to ensure the uniformity and reliability of concrete placement.The 'Digital Dam' for the Xiluodu project,which is based on the theory of total life cycle,has supplied strong support for construction process control and decision-making. | Lu Youmei Fan Qixiang Zhou Shaowu Li Bingfeng Li Wenwei | 2012 | Engineering Sciences2012，10，2： | 3 |
| 14 | A new approach to the bicyclo[3.3.1]nonane framework of huperzine A-like molecules via palladium-catalyzed intramolecular γ-arylation显示文摘In our synthetic studies toward huperzine A, a diastereoselective α′-alkylation of the α-amido-γ-methyl hexenone 4 was realized through a dianion intermediate which significantly enhanced the reactivity. Under the attempted Heck reaction conditions, an unexpected and unprecedented palladium-catalyzed intramolecular γ-arylation of 3 was observed, which generated 18 with bicyclo[3.3.1]nonane framework in satisfactory yield. | DING Rui LU YunYu YAO HeQuan SUN BingFeng LIN GuoQiang | 2012 | Science China Chemistry2012，55，6： | 2 |
| 15 | Adaptive Integrated Guidance and Control Based on Backstepping and I nput‐to‐ S tate S tability显示文摘 | Han Yan Xinghu Wang Bingfeng Yu Haibo Ji | 2014 | Asian J Control2014，，2： | 2 |
| 16 | Dynamic deformation behavior of a FeCrNi medium entropy alloy显示文摘Deformation behavior of a FeCrNi medium entropy alloy(MEA)prepared by powder metallurgy(P/M)method was investigated over a wide range of strain rates.The FeCrNi MEA exhibits high strain-hardening ability,which can be attributed to the multiple deformation mechanisms,including dislocation slip,deformation induced stacking fault and mechanical twinning.The shear localization behavior of the FeCrNi MEA was also analyzed by dynamically loading hat-shaped specimens,and the distinct adiabatic shear band cannot be observed until the shear strain reaches~14.5.The microstructures within and outside the shear band exhibit different characteristics:the grains near the shear band are severely elongated and significantly refined by dislocation slip and twinning;inside the shear band,the initial coarse grains completely disappear,and transform into recrystallized ultrafine equiaxed grains by the classical rotational dynamic recrystallization mechanism.Moreover,microvoids preferentially nucleate in the central areas of the shear band where the temperature is very high and the shear stress is highly concentrated.These microvoids will coalesce into microcracks with the increase of strain,which eventually leads to the fracture of the shear band. | Ao Fu Bin Liu Zezhou Li Bingfeng Wang Yuankui Cao Yong Liu | 2022 | Journal of Materials Science & Technology2022，，5： | 2 |
| 17 | Mechanisms and characteristics of mesocarbon microbeads prepared by co-carbonization of coal tar pitch and direct coal liquefaction residue显示文摘DCLR-P was prepared by direct coal liquefaction residue (DCLR) with ash removal.In the present experiments,mesocarbon microbeads (MCMBs) were prepared by co-carbonization of coal tar pitch (CTP) and DCLR-P.With the increase of DCLR-P content,the yield of MCMBs increased from 47.8% to 56.8%.At the same time,the particle sizes distribution of MCMBs was narrowed,resulting in the decrease of D9o/D10 ratio from 154.88 to 6.53.The results showed that DCLR-P had a positive effect on the preparation of MCMBs.1H-NMR,FTIR,SEM and XRD were used to analyze the mechanisms and characteristics of MCMBs prepared by co-carbonization of CTP and DCLR-P.The results showed that the Proton Donor Quality Index (PDQI) of DCLR-P was 13.32,significantly higher than that of CTP (0.83).This indicated that DCLR-P had more naphthenic structure than CTP,which leads to hydrogen transferring in polycondensation reaction.The aliphatic structure of DCLR-P can improve the solubility and fusibility of mesophase,thereby making the structure of MCMBs more structured.The microstructure of the graphitized MCMBs had a substantially parallel carbon layer useful for its electrical performance.The performance of graphitized MCMBs as a negative electrode material for Li-ion batteries was tested.The particle sizes,tap density,specific surface area and initial charge-discharge efficiency of graphitized MCMBs met the requirements of CMB-I in GB/T-24533-2009.However,the initial discharge capacity of graphitized MCMB was only 296.3 mA h g-1 due to the low degree of graphitization of MCMBs. | Bingfeng Yan Guangyao Wang | 2019 | International Journal of Coal Science & Technology2019，6，4： | 2 |
| 18 | Significantly reduced abilities to cross-neutralize SARS-CoV-2 variants by sera from convalescent COVID-19 patients infected by Delta or early strains显示文摘The worldwide pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 4.5 million deaths.Although coronaviruses have a proofreading mechanism to maintain the stability of their long genomic RNAs,mutations emerge continuously,and new variants conferring advantages rapidly become the dominant lineages[1].Strategies to fight the COVID-19 pandemic using either vaccines or nonpharmaceutical interventions have specifically been threatened by the emergence of SARS-CoV-2 variants of concern(VOCs)[2]. | Ting Pan Zhongwei Hu Fengyu Hu Yiwen Zhang Bingfeng Liu Changwen Ke Qiumin She Xin He Xiaoping Tang Hui Zhang | 2021 | Cellular & Molecular Immunology2021，18，11： | 1 |
| 19 | Multifunctional poly ( d,1-lactide-co-glycolide )/montmorillonite ( PLGA/MMT ) nanoparticles decorated by Trastuzumab for targeted chemotherapy of breast cancer 显示文摘 | Sun Bingfeng Balu Ranganathan Feng Si-Shen | 2008 | Biomaterials2008，29，4： | 1 |
| 20 | Research on performance of regenerative room temperature magnetic refrigeration cycle 显示文摘 | Yu Bingfeng Zhang Yan Gao Qiang | 2006 | International Journal of Refrigeration2006，29，8： | 1 |
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