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| 1 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 2 | Antioxidants,inflammation and cardiovascular disease显示文摘Multiple factors are involved in the etiology of cardiovascular disease(CVD). Pathological changes occur in a variety of cell types long before symptoms become apparent and diagnosis is made. Dysregulation of physiological functions are associated with the activation of immune cells,leading to local and finally systemic inflammation that is characterized by production of high levels of reactive oxygen species(ROS). Patients suffering from inflammatory diseases often present with diminished levels of antioxidants either due to insufficient dietary intake or,and even more likely,due to increased demand in situations of overwhelming ROS production by activated immune effector cells like macrophages. Antioxidants are suggested to beneficially interfere with diseases-related oxidative stress,however the interplay of endogenous and exogenous antioxidants with the overall redox system is complex. Moreover,molecular mechanisms underlying oxidative stress in CVD are not fully elucidated. Metabolic dybalances are suggested to play a major role in disease onset and progression. Several central signalingpathways involved in the regulation of immunological,metabolic and endothelial function are regulated in a redox-sensitive manner. During cellular immune response,interferon γ-dependent pathways are activated such as tryptophan breakdown by the enzyme indoleamine 2,3-dioxygenase(IDO) in monocyte-derived macrophages,fibroblasts,endothelial and epithelial cells. Neopterin,a marker of oxidative stress and immune activation is produced by GTP-cyclohydrolase Ⅰ in macrophages and dendritic cells. Nitric oxide synthase(NOS) is induced in several cell types to generate nitric oxide(NO). NO,despite its low reactivity,is a potent antioxidant involved in the regulation of the vasomotor tone and of immunomodulatory signaling pathways. NO inhibits the expression and function of IDO. Function of NOS requires the cofactor tetrahydrobiopterin(BH4),which is produced in humans primarily by fibroblasts and endothelial cells. Highly toxic peroxynitrite(ONOO-) is formed solely in the presence of superoxide anion(O2-). Neopterin and kynurenine to tryptophan ratio(Kyn/Trp),as an estimate of IDO enzyme activity,are robust markers of immune activation in vitro and in vivo. Both these diagnostic parameters are able to predict cardiovascular and overall mortality in patients at risk. Likewise,a significant association exists between increase of neopterin concentrations and Kyn/Trp ratio values and the lowering of plasma levels of vitamin-C,-E and-B. Vitamin-B deficiency is usually accompanied by increased plasma homoycsteine. Additional determination of NO metabolites,BH4 and plasma antioxidants in patients with CVD and related clinical settings can be helpful to improve the understanding of redox-regulation in health and disease and might provide a rationale for potential antioxidant therapies in CVD. | Harald Mangge Kathrin Becker Dietmar Fuchs Johanna M Gostner | 2014 | World Journal of Cardiology2014，6，6： | 25 |
| 3 | Role of receptor tyrosine kinases in gastric cancer: New targets for a selective therapy显示文摘受体酷氨酸家族 ases (RTK ) 象表皮的生长因素受体家庭那样包括增长和变形传播参予肿瘤形成的几步。几已知的 RTK 起来在是主要的胃的癌症调整了定制的治疗的目标。仅仅初步的数据然而,在使用上存在当前临床上可得到的药象在胃的癌症的背景的 trastuzumab, cetuximab, bevacizumab, gefitinib, erlotinib,和 imatinib 那样。现出症状之前的潜的数据建议他们的使用的一个潜在的好处,特别在有“常规”的抑制细胞的联合治疗。这评论象新途径和药一样在癌症治疗关于他们的使用总结当前的知识优化治疗成功。 | JC Becker C Müller-Tidow H Serve W Domschke T Pohle | 2006 | World Journal of Gastroenterology2006，12，21： | 19 |
| 4 | New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal p H metry in extraesophageal gastroesophageal reflux disease显示文摘AIM:To determine the laryngeal H+K+-ATPase and pharyngeal p H in patients with laryngopharyngeal reflux(LPR)-symptoms as well as to assess the symptom scores during PPI therapy.METHODS:Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area(immunohistochemistry and PCR analysis).Immunohistochemical staining was performed with monoclonal mouse antibodies against human H+K+-ATPase.Quantitative real-time RT-PCR for each of the H+K+-ATPase subunits was performed.The p H values were assessed in the aerosolized environment of the oropharynx(Dxp H Catheter) and compared to a subsequently applied combined p H/MII measurement.RESULTS:Twenty patients with LPR symptoms were included.In only one patient,the laryngeal H+K+-ATPase was verified by immunohistochemical staining.In another patient,real-time RT-PCR for each H+K+-ATPase subunit was positive.Fourteen out of twenty patients had pathological results in Dxp H,and 6/20 patients had pathological results in p H/MII.Four patients had pathological results in both functional tests.Nine out of twenty patients responded to PPIs.CONCLUSION:The laryngeal H+K+-ATPase can only be sporadically detected in patients with LPR symptoms and is unlikely to cause the LPR symptoms.Alternative hypotheses for the pathomechanism are needed.The role of pharyngeal p H-metry remains unclearand its use can only be recommended for patients in a research study setting. | Valentin Becker Romina Drabner Simone Graf Christoph Schlag Simon Nennstiel Anna Maria Buchberger Roland M Schmid Dieter Saur Monther Bajbouj | 2015 | World Journal of Gastroenterology2015，21，3： | 14 |
| 5 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 6 | 急性冠状动脉综合征发生1个月后的生长分化因子15水平与主要出血风险增加相关显示文摘用双重抗血小板治疗的急性冠状动脉综合征(acutecoronarysyndromes,ACS)患者在初次就诊测量的生长分化因子15(growthdifferentiationfactor-15,GDF-15)与大出血相关。 | Lindholm D Hagstrm E James SK Becker RC Cannon CP Himmelmann A Katus HA Maurer G López-Sendón JL Steg PG Storey RF Siegbahn A Wallentin L 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 5 |
| 7 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 8 | Cloning molecular characterization and function activity of Schistosoma japonicum glyceraldehyde-3-phosphate dehydrogenase, a putative vaccine candidate against Schistosoma japonicum 显示文摘 | Waine GJ Becker M Yang W | 1993 | Infect Immun1993，61，： | 2 |
| 9 | Determination of tate constants for the reactions of the CH2SH radical with O2,O3 and NO2 at 298 K 显示文摘 | RAHMAN M M BECKER E WILLE U | 1992 | Ber Bunsen-ges Phys Chem1992，96，： | 2 |
| 10 | Evaluating the performance of biologically active rapid filters 显示文摘 | Lechevallier M W William C Becker Paul Schorr | 1992 | J AWWA1992，84，4： | 2 |
| 11 | Combined evaluation of a panel of protein and miRNA serum‐exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity显示文摘 | Bindhu Madhavan Shijing Yue Uwe Galli Sanyukta Rana Wolfgang Gross Miryam Müller Nathalia A. Giese Holger Kalthoff Thomas Becker Markus W Büchler Margot Z?ller | 2015 | Int. J. Cancer2015，，11： | 2 |
| 12 | The cost of hospitalization in Crohn’s disease显示文摘 | Russell D Cohen Leanne R Larson Joel M Roth Russell V Becker Lisa L Mummert | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 13 | Filamentation “remote” sensing of chemical and biological agents/pollutants using only one femtosecond laser source显示文摘 | S. L. Chin H. L. Xu Q. Luo F. Théberge W. Liu J. F. Daigle Y. Kamali P. T. Simard J. Bernhardt S. A. Hosseini M. Sharifi G. Méjean A. Azarm C. Marceau O. Kosareva V. P. Kandidov N. Ak?zbek A. Becker G. Roy P. Mathieu J. R. Simard M. Chateauneuf J. Dubois | 2009 | Applied Physics B2009，，1： | 2 |
| 14 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 15 | Integrated rice-fish culture: Coupled production saves resources显示文摘 | Frei M Becker K | 2005 | Natural Resources Forum2005，29，： | 1 |
| 16 | Hyperuricemia and associated disease 显示文摘 | Becker MA Jolly M | 2006 | Rheum Dis Clin North Am2006，32，2： | 1 |
| 17 | Guided tissue regeneration for implants placed into extraction sockets:a study in dogs显示文摘 | Becket W Becker BE Handclsman M | 1991 | J Periodomol1991，62，11： | 1 |
| 18 | Cell cycle phase-specific surface expression of nerve growth factor receptors TrkA and p75 (NGF)显示文摘 | Becker E Andrieu M | 1998 | J Neurosci1998，18，： | 1 |
| 19 | Post- traumatic stress disorder symptoms following media exposure to tragic events: Impact of 9/11 on children at risk for anxiety disorders显示文摘 | Otto M W Henin A Hirshfeld- Becker D R | 2007 | Journal of Anxiety Disorders2007，21，7： | 1 |
| 20 | Risk stratification and outcomes of transluminal endografting for abdominal aortic aneurysm: 72-year experience and long-term follow-up显示文摘 | BECKER G J KOVACS M MATHISON M N | 2001 | J Vase Interv Radiol2001，12，9： | 1 |
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