|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy显示文摘AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment regimen.METHODS: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading system.RESULTS: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor regression.CONCLUSION: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes. | Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker Gustavo B Baretton Daniela E Aust | 2008 | World Journal of Gastroenterology2008，14，7： | 29 |
| 2 | Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection显示文摘Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it is still curable is dependent on our ability to identify and screen high-risk populations before their symptoms arise. Risk factors for developing pancreatic cancer include multiple genetic syndromes as well as modifiable risk factors. Genetic conditions include hereditary breast and ovarian cancer syndrome, Lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Syndrome, familial atypical multiple mole melanoma syndrome, hereditary pancreatitis, cystic fibrosis, and ataxia-telangiectasia; having a genetic predisposition can raise the risk of developing pancreatic cancer up to 132-fold over the general population. Modifiable risk factors, which include tobacco exposure, alcohol use, chronic pancreatitis, diet, obesity, diabetes mellitus, as well as certain abdominal surgeries and infections, have also been shown to increase the risk of pancreatic cancer development. Several largevolume centers have initiated such screening protocols, and consensus-based guidelines for screening high-riskgroups have recently been published. The focus of this review will be both the genetic and modifiable risk factors implicated in pancreatic cancer, as well as a review of screening strategies and their diagnostic yields. | Andrew E Becker Yasmin G Hernandez Harold Frucht Aimee L Lucas | 2014 | World Journal of Gastroenterology2014，20，32： | 24 |
| 3 | 急性冠状动脉综合征发生1个月后的生长分化因子15水平与主要出血风险增加相关显示文摘用双重抗血小板治疗的急性冠状动脉综合征(acutecoronarysyndromes,ACS)患者在初次就诊测量的生长分化因子15(growthdifferentiationfactor-15,GDF-15)与大出血相关。 | Lindholm D Hagstrm E James SK Becker RC Cannon CP Himmelmann A Katus HA Maurer G López-Sendón JL Steg PG Storey RF Siegbahn A Wallentin L 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 5 |
| 4 | Determination of tate constants for the reactions of the CH2SH radical with O2,O3 and NO2 at 298 K 显示文摘 | RAHMAN M M BECKER E WILLE U | 1992 | Ber Bunsen-ges Phys Chem1992，96，： | 2 |
| 5 | Cell cycle phase-specific surface expression of nerve growth factor receptors TrkA and p75 (NGF)显示文摘 | Becker E Andrieu M | 1998 | J Neurosci1998，18，： | 1 |
| 6 | Keeping the blades turning:condition monitoring of wind turbine gears显示文摘 | Becker E Poste Pard | 2006 | Wind Energy2006，7，2： | 1 |
| 7 | Beyond knowledge sharing:The management of transactive knowledge systems显示文摘 | BRAUNER E BECKER A | 2006 | Knowledge and Process Management2006，13，1： | 1 |
| 8 | Three-Dimensional Numerical Simulation of Flow and Heat Transport in HighTemperature Nuclear Reactors显示文摘 | Becker S Laurien E | 2003 | Nuclear Engineering and Design2003，222，23： | 1 |
| 9 | Inhibition of human brain and RBC acetylcholinesterase (ACHE) by heptylphysostigmine (HPTL)显示文摘 | Moriearty P L Becker R E | 1992 | Methods Find Exp Clin Pharmacol1992，14，8： | 1 |
| 10 | Procalcitonin assay in sys- temic inflammation, infection, and sepsis: clinical utility and limitations显示文摘 | Becker K L Snider R Nylen E S | 2008 | Crit Care Med2008，36，3： | 1 |
| 11 | Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation显示文摘 | Onno J de Boer Floris Hirsch Allard C van der Wal Chris M van der Loos Pranab K Das Anton E Becker | 1997 | Atherosclerosis1997，，2： | 1 |
| 12 | Thioredoxin and glutathione systems in Plasmodium falciparum 显示文摘 | Jortzik E Becker K | 2012 | Int Med Microbiol2012，302，45： | 1 |
| 13 | Constitutive modeling of viscoelastic materials with damage: Computational aspects 显示文摘 | Conga M E Becker E B Ozupek S | 2001 | Computer Methods in Applied Mechanics and Engineering2001，190，1517： | 1 |
| 14 | Strategic human resource management : where do we go from here? 显示文摘 | Becker B E Huselid M A | 2006 | Journal of Management2006，，32： | 1 |
| 15 | Potential versus Actual Faking of a Biodata Form: An Analysis along Several Dimensions of Item Type显示文摘 | Becker T E Colquitt A L | 1992 | Personnel Psychology1992，45，2： | 1 |
| 16 | Novel mutation - specific monoclonal E - cadherin antibodies make possible allele differentiation at the protein level in tumors 显示文摘 | Becker I Becker KF Kremmer E | 1999 | Verh Dtsch Ges Pathol1999，83，： | 1 |
| 17 | Solid-phase crystalli-zation of amorphous silicon on ZnO:Al for thin-film solar cells显示文摘 | Becker C Conrad E Dogan P | 2009 | Solar Energy Mater Solar Cells2009，93，： | 1 |
| 18 | 显示文摘 | Jaffe E A Nachman R L Becker C G | 1973 | J Clin Invest1973，52，： | 1 |
| 19 | Mechanism of carbon tetrachloride-induced hepatotoxicity显示文摘 | Boll M Weber LW Becker E | 2001 | Z Naturforsch2001，56，78： | 1 |
| 20 | Potential Problems in the Statistical Control of Variables in Organizational Research: A Qualitative Analysis with Recommendations 显示文摘 | Becker T E | 2005 | Organizational Research Methods2005，8，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员