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| 1 | 监测降钙素原指导抗生素治疗显示文摘降钙素原(PCT)是一种可用于评估细菌感染可能性的生物学标志物。用PCT指导抗生素治疗是减少其滥用的一种新的手段,这有助于降低抗生素不良反应及多重耐药菌出现的风险。然而,对PCT水平的解读必须密切结合临床实际情况和检测方法的特性。在临床实践中,我们应使用敏感度较高的PCT检测方法,并根据临床实际情况确定具体的检测界值。现将PCT水平检测对指导不同临床表现和不同潜在感染患者抗生素治疗的优点和局限性概述如下。 | Philipp Schuetz Werner Albrich Beat Mueller Miriam Christ-Crain Jean Chastre | 2013 | 中华结核和呼吸杂志2013，36，7： | 4 |
| 2 | Do you want to participate in a clinical study as a healthy control?-Risk or benefit?显示文摘A healthy woman volunteered to participate as 'healthy control' in a study.An increased level of procalcitonin(PCT) was detected and remained elevated on follow-up measurements.As calcitonin levels were elevated as well,thyroid ultrasound was performed which revealed nodes in both thyroid lobes,one of them showing metabolic activity in positron emission tomography-computed tomography scan.To exclude a malignant thyroid cancer despite the negative findings in a fine needle aspiration the patient underwent thyroidectomy and a medullary thyroid carcinoma(MTC) was detected in the right lobe.MTC is a rare endocrine tumor with a poor prognosis once having spread,therefore early detection remains a priority for the outcome.Screening parameter is serum calcitonin,in absence of infection the pro-hormone PCT can be used as a screening parameter as well with high sensitivity. | Hanna Giessen Christian A Nebiker Matthias Bruehlmeier Stefan Spreitzer Beat Mueller Philipp Schuetz | 2017 | World Journal of Clinical Cases2017，5，12： | 2 |
| 3 | Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial显示文摘 | Philipp Schuetz Alexander Kutz Eva Grolimund Sebastian Haubitz Désirée Demann Alaadin V?geli Fabienne Hitz Mirjam Christ-Crain Robert Thomann Claudine Falconnier Claus Hoess Christoph Henzen Robert J. Marlowe Werner Zimmerli Beat Mueller | 2014 | International Journal of Cardiology2014，，3： | 2 |
| 4 | Low-density lipoprotein receptor variants are associated with spontaneous and treatment-induced recovery from hepatitis C virus infection显示文摘 | Andreas Mas Marques Tobias Mueller Justus Welke Stefan Taube Christoph Sarrazin Manfred Wiese Juliane Halangk Heiko Witt Golo Ahlenstiel Ulrich Spengler Uwe Goebel Eckart Schott Viola Weich Beate Schlosser Hermann E. Wasmuth Frank Lammert Thomas Berg Ecka | 2009 | Infection, Genetics and Evolution2009，，5： | 1 |
| 5 | Comparison of the oxidative resistance of various polyolefin显示文摘 | Wemer Mueller Beate Buettgenbach Ines Jakob Heidemarie Mann | 2003 | Geotextiles and Geomembranes2003，，21： | 1 |
| 6 | Effect of hyperglycaemia on inflammatory and stress responses and clinical outcome of pneumonia in non-critical-care inpatients: results from an observational cohort study显示文摘 | Philipp Schuetz Natalie Friedli Eva Grolimund Alexander Kutz Sebastian Haubitz Mirjam Christ-Crain Robert Thomann Werner Zimmerli Claus Hoess Christoph Henzen Beat Mueller | 2014 | Diabetologia2014，，2： | 1 |
| 7 | Christian Is there a clinical relevance of partial androgen deficiency of the aging male显示文摘 | Christ-Crain Mirjam Mueller Beat Gasser Thomas C | 2004 | Joumal of Urology2004，172，2： | 1 |
| 8 | Procalcitonin for diagnosis of infection and guide to antibiotic decisions:past,present and future显示文摘 | Philipp Schuetz Werner Albrich Beat Mueller | 2011 | BMC Med2011，9，： | 1 |
| 9 | Procalcitonin and the Early Diagnosis of Infective Endocarditis显示文摘 | Christian Mueller Peter Huber Gerd Laifer Beat Mueller André P. Perruchoud | 2004 | Circulation: Journal of the American Heart Association2004，，14： | 1 |
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