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| 1 | 克罗恩病肠切除术后复发影响因素的研究进展显示文摘克罗恩病(Crohn′s disease, CD)以内科治疗为主,但有很大比例的患者因急症或并发症需行肠切除手术。肠切除术后CD病情可获得暂时缓解,但复发率高,需反复手术的风险较高。本文从患者自身因素、手术相关因素和术后内科治疗等角度对与肠切除术后复发风险相关的因素进行综述,以期通过综合控制各种影响因素,降低术后复发风险,提高CD患者生存质量。 | 陈善稳 王鹏远 刘玉村 | 2015 | 中华胃肠外科杂志2015，18，1： | 2 |
| 2 | Prevention of post-operative recurrence of Crohn's disease显示文摘Endoscopic and clinical recurrence of Crohn’s disease(CD)is a common occurrence after surgical resection.Smokers,those with perforating disease,and those with myenteric plexitis are all at higher risk of recurrence.A number of medical therapies have been shown to reduce this risk in clinical trials.Metronidazole,thiopurines and anti-tumour necrosis factors(TNFs)are all effective in reducing the risk of endoscopic or clinical recurrence of CD.Since these are preventative agents,the benefits of prophylaxis need to be weighed-against the risk of adverse events from,and costs of,therapy.Patients who are high risk for post-operative recurrence should be considered for early medical prophylaxis with an anti-TNF.Patients who have few to no risk factors are likely best served by a three-month course of antibiotics followed by tailored therapy based on endoscopy at one year.Clinical recurrence rates are variable,and methods to stratify patients into high and low risk populations combined with prophylaxis tailored to endoscopic recurrence would be an effective strategy in treating these patients. | Byron Philip Vaughn Alan Colm Moss | 2014 | World Journal of Gastroenterology2014，20，5： | 1 |
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