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| 1 | 肝腺瘤四种亚型的影像学表现与病理学基础显示文摘肝腺瘤(hepatocellular adenomas,HCA)是一种罕见的良性肿瘤,通常发生在没有肝硬化的肝脏。主要见于育龄妇女,男女比例为1∶8~1∶10^([1])。HCA的发生与口服避孕药的使用有关已经得到广泛的认可,并且与口服避孕药的剂量和时间密切相关。然而,最近来自亚洲国家的报道显示肝腺瘤在东西方患者间表现出显著的流行病学差异。在亚洲国家,HCA的报道以男性居多, | 徐淑敏 江芮 赵新湘 | 2018 | 临床放射学杂志2018，37，3： | 8 |
| 2 | Hepatocellular Tumors:Immunohistochemical Analyses for Classification and Prognostication显示文摘Following the classification of hepatocellular nodules by the International Working Party in 1995 and further elaboration by the International Consensus Group for Hepatocellular Neoplasia in 2009,entities under the spectrum of hepatocellular nodules have been better characterized.Research work hence has been done to answer questions such as distinguishing high-grade dysplastic nodules from early hepatocellular carcinoma (HCC),delineating the tumor cell origin of HCC,identifying its prognostic markers,and subtyping hepatocellular adenomas.As a result,a copious amount of data at immunohistochemical and molecular levels has emerged.A panel of immunohistochemical markers including glypican-3,heat shock protein 70 and glutamine synthetase has been found to be of use in the diagnosis of small,well differentiated hepatocellular tumors and particularly of HCC.The use of liver fatty acid binding protein (L-FABP),β-catenin,glutamine synthetase,serum amyloid protein and C-reactive protein is found to be helpful in the subtyping of hepatocellular adenomas.The role of tissue biomarkers for prognostication in HCC and the use of biomarkers in subclassifying HCC based on tumor cell origin are also discussed. | Regina Cheuk-Lam Lo Irene Oi-Lin Ng | 2011 | Chinese Journal of Cancer Research2011，23，4： | 5 |
| 3 | 单中心肝细胞核因子1A失活型肝细胞腺瘤临床病理特征显示文摘目的:探讨肝细胞核因子1A(hepatocyte nuclear 1A,HNF1A)失活型肝细胞腺瘤(hepatocellular adenoma,HCA)的临床病理特征,提高此类肿瘤的认识。方法:收集2002年至2017年复旦大学附属中山医院经手术切除并诊断为HCA的102例病例资料,经免疫组化分型后,分析HNF1A失活型HCA的相关临床资料及观察形态学特点。结果:HNF1A失活型HCA共17例,占16.7%(17/102)。女性患者与男性患者比例为13∶4,平均年龄为33岁,均无糖尿病、糖原累积症及饮酒史。94.1%(16/17)病例因体检发现肝占位就诊。肿瘤多为单发(12/17),且形态学多为脂肪变性(12/17)。结论:HNF1A失活型HCA较少恶变为肝细胞肝癌,在肝腺瘤病病例中,要警惕肿瘤异质性并密切随访。 | 韩晶 陈伶俐 张欣 纪元 | 2020 | 中国临床医学2020，27，3： | 2 |
| 4 | 慢性再生障碍性贫血长期使用雄激素继发肝腺瘤一例并文献复习显示文摘报道一例慢性再生障碍性贫血(CAA)长期使用雄激素继发肝腺瘤并进行文献复习,提示长期服用雄激素类药物的CAA患者为肝脏性激素相关肿瘤发病高危人群,应予以重视。 | 徐玲珑 施瑛 应丽梅 陆妮娜 周郁鸿 | 2018 | 中华全科医师杂志2018，17，5： | 2 |
| 5 | 肝细胞腺瘤的研究进展显示文摘肝细胞腺瘤(hepatocellular adenoma,HCA)是肝内十分少见的良性肿瘤,多数学者认为其起源于肝实质细胞,也有学者认为起源于肝始祖细胞,女性的发病率约为万分之一。目前对该病尚缺乏足够的认识,其临床、影像及病理学诊断都有一定困难,故临床上极易误诊,导致不恰当的治疗。本文就HCA的研究进展综述如下。 | 周斌 张培建 | 2008 | 中华外科杂志2008，46，9： | 1 |
| 6 | 肝细胞核因子1α在肝脏肿瘤发生和发展中的作用及机制显示文摘肝细胞核因子1α(HNF1α)是HNF家族的重要成员,其主要在肝脏表达,可通过转录调控多种肝脏代谢相关基因,直接或间接调节肝脏代谢功能及肝细胞的增殖、分化等过程。近年来研究发现,肝脏肿瘤中存在HNF1α的突变及表达改变,而且HNF1α高表达可抑制肝细胞癌(HCC)的进展,表明HNF1α在肝脏肿瘤的发生、发展过程中发挥着重要作用,是HCC治疗的潜在靶点。该文就HNF1α在肝脏肿瘤发生、发展中的作用及机制研究进展作一综述。 | 聂美桐 张新 谢渭芬 | 2021 | 国际消化病杂志2021，41，6： | 0 |
| 7 | 在年轻女性的 hepatocellular 腺瘤和焦点的榴状的增生的共存显示文摘 Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HA) are both benign hepatocellular lesions, presenting mainly in women of childbearing age in non-cirrhotic, non-fibrotic livers. Simultaneous occur-rence of these two lesions is extremely rare. We herein report a case of a young female without any predis-posing risk factors who presented to our emergency department complaining of acute abdominal pain. Imaging studies revealed a 6 cm lesion in the right hepatic lobe and a 2.5 cm lesion in the left hepatic lobe, respectively. In view of the patient’s symptoms and lack of a confirmed diagnosis based on imaging, we performed a bisegmentectomy Ⅴ-Ⅵ and a wedge resection of the lesion in segment Ⅲ by laparotomy. Postoperative course was uneventful and the patient was discharged on the fourth postoperative day. The pathology report demonstrated an HA in segments Ⅴ-Ⅵ and FNH in segment Ⅲ, respectively. Six months later, the patient remains asymptomatic with normal liver function tests, ultrasound and magnetic reso-nance imaging follow-up. To our best knowledge, this is the first case to describe simultaneous occurrence of HA and FNH without the presence of any known risk factors for these entities. The uncertainty in diagnosis and acuteness of presenting symptoms were estab-lished criteria for prompt surgical intervention. | Dimitrios Dimitroulis Panagiotis Lainas Petros Chara-lampoudis Theodore Karatzas Nikolaos Karidis Gregory Kouraklis Ioanna Delladetsima Nikolaos Karidis Gregory Kouraklis Stratigoula Sakellariou | 2012 | World Journal of Hepatology2012，4，11： | 0 |
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