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| 1 | A dopamine and noradrenaline reuptake inhibitor (bupropion) does not alter exercise performance of bank voles显示文摘 | Ewa JAROMIN Edyta Teresa SADOWSKA Pawet KOTEJA | 2016 | Current Zoology2016，62，3： | 3 |
| 2 | Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone显示文摘Discriminating sterile inflammation from infection, especially in cases of aseptic loosening versus an actual prosthetic joint infection, is challenging and has significant treatment implications. Our goal was to evaluate a novel human monoclonal antibody(mAb) probe directed against the Gram-positive bacterial surface molecule lipoteichoic acid(LTA). Specificity and affinity were assessed in vitro. We then radiolabeled the anti-LTA mAb and evaluated its effectiveness as a diagnostic imaging tool for detecting infection via immuno PET imaging in an in vivo mouse model of prosthetic joint infection(PJI). In vitro and ex vivo binding of the anti-LTA mAb to pathogenic bacteria was measured with Octet, ELISA, and flow cytometry. The in vivo PJI mouse model was assessed using traditional imaging modalities, including positron emission tomography(PET) with [^(18)F]FDG and [^(18)F]Na F as well as X-ray computed tomography(CT), before being evaluated with the zirconium-89-labeled antibody specific for LTA([^(89)Zr]SAC55).The anti-LTA mAb exhibited specific binding in vitro to LTA-expressing bacteria. Results from imaging showed that our model could reliably simulate infection at the surgical site by bioluminescent imaging, conventional PET tracer imaging, and bone morphological changes by CT. One day following injection of both the radiolabeled anti-LTA and isotype control antibodies, the anti-LTA antibody demonstrated significantly greater(P < 0.05) uptake at S. aureus-infected prosthesis sites over either the same antibody at sterile prosthesis sites or of control non-specific antibody at infected prosthesis sites. Taken together, the radiolabeled anti-LTA mAb, [^(89)Zr]SAC55, may serve as a valuable diagnostic molecular imaging probe to help distinguish between sterile inflammation and infection in the setting of PJI. Future studies are needed to determine whether these findings will translate to human PJI. | Julie E.Pickett John M.Thompson Agnieszka Sadowska Christine Tkaczyk Bret R.Sellman Andrea Minola Davide Corti Antonio Lanzavecchia Lloyd S.Miller Daniel LJ Thorek | 2018 | Bone Research2018，6，2： | 3 |
| 3 | Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: Discordant in vitro and in vivo dose-effects: A review显示文摘 | A.M. Sadowska B. Manuel-y-Keenoy W.A. De Backer | 2006 | Pulmonary Pharmacology & Therapeutics2006，，1： | 2 |
| 4 | The influence of different acids and pepsin on the extractability of collagen from the skin of Baltic cod (Gadus morhua)显示文摘 | ELZBIETA S SADOWSKA M | 2007 | Food Chemistry2007，105，： | 1 |
| 5 | Pregnancy in women with systemic lupus erythematosus (SLE) 显示文摘 | Sadowska A | 2005 | Przegl Lek2005，62，1： | 1 |
| 6 | Genetic Variation in Bank Vole Populations in Natural and Metal-Contaminated Areas 显示文摘 | Magdalena Mikowska Aneta Gaura Edyta Sadowska | 2014 | Archives of EnvironmentalContamination Toxicology2014，67，： | 1 |
| 7 | The impact of immune response on lung cancer and the development of new treatment modalities显示文摘 | Pluygers E Sadowska A Chyezewski L | 2001 | Lung Cancer2001，34，2： | 1 |
| 8 | Lysostaphin as a potential therapeutic agent for staphylococcal biofilm eradication显示文摘 | Walencka E Sadowska B Rozalska S | 2005 | Pol J Microbiol2005，54，3： | 1 |
| 9 | A novel,broad-spectrum anticancer compound containing the imidazodiazepine ring system显示文摘 | XIE M UJJINAMATADA R K SADOWSKA M | 2010 | Bioorg Med Chem Lett2010，20，15： | 1 |
| 10 | Characteristics of staphylococcus aureus,isolated from airways of cystic fibrosis patients,and their small colony variants显示文摘 | Sadowska B Bonar A von Eiff C | | 0，，： | 1 |
| 11 | Isolation of collagen from the skins of Balitic cod (Gadus morhua)显示文摘 | Sadowska M Kolodziejska I Niecikowska C | 2003 | Food Chemistry2003，，81： | 1 |
| 12 | Lenti l starch content and its microscopical structure as influenced by natural fermenta tion显示文摘 | Cristina Sotomayer Juana Frias Jozef Fornal Jaga Sadowska | 1999 | Starch/Strke1999，51，： | 1 |
| 13 | The impact of immune response on lung cancer and the deve-lopment of new treatment modalities显示文摘 | PLUYGERS E SADOWSKA A CHYCZEWSKI L | 2001 | Lung Cancer2001，，： | 1 |
| 14 | Use of ICAM - 1 antibodies and antisense oligonucleotides to in- hibit transmigration of neutrophils 显示文摘 | SADOWSKA A M VAN OVERVELD F J LUYTEN C | 2004 | Inflamm Res2004，53，4： | 1 |
| 15 | Antioxi- dant and anti-imqammatory efficacy of NAC in the treatment of COPD: Discordant in vitro and in vivo Dose-effects: Areview 显示文摘 | Sadowska AM Manuel Y-Keenoy B De Backer WA | 2007 | Pulm Pharmacoi Ther2007，20，1： | 1 |
| 16 | The structure of human SFPQreveals a coiled -coil mediated polymer essential for functionalaggregation in gene regulation显示文摘 | Lee M Sadowska A Bekere I | 2015 | Nucleic Acids Res2015，43，7： | 1 |
| 17 | The influence of different acids and pepsin on the extractability of collagen from the skin of Baltic cod (Gadus mothua)显示文摘 | El_zbieta Skierka Maria Sadowska | 2007 | Food chemistry2007，105，： | 1 |
| 18 | Isolation of collagen from the skins of Baltic cod(Gadus morhua)显示文摘 | SADOWSKA M KOLODZIEJSKA I NIECIKOWSKA C | 2003 | Food Chem- istry2003，81，2： | 1 |
| 19 | Isolation and some properties of collagen from the backbone of Baltic cod (Gadus morhua)显示文摘 | Zelechowska E Sadowska M Turk M | | 0，，04： | 1 |
| 20 | The influence of different acids and pepsin on extractability of collagen from the skin Baltic cod (Gadus morhua)显示文摘 | Elzbieta Skierka Maria Sadowska | | 0，，： | 1 |
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