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| 1 | 农业耕作活动对西藏越冬黑颈鹤食性及食物可获得性的影响显示文摘于 1996年 1月对在西藏中南部越冬黑颈鹤的食性和谷物性食物的可获得性进行了研究。青稞 (Hordeumvulgare)、春小麦 (Triticumspp .)、冬小麦 (Triticumspp .)是该地区的 3种主要作物。对黑颈鹤粪便的分析表明 ,越冬黑颈鹤取食大量的农作物 ,尤其是小麦散落谷粒 ,而冬小麦苗仅占鹤类食物组成的很小一部分。秋收后的翻耕、放牧等农业活动影响地面上作物残物 (种子、叶、秆或根 )及谷粒残物 (裸粒、穗、稃 )的数量 ,农地翻耕掩埋了大部分的作物残物。未翻耕青稞地与小麦地上的作物残物覆盖比值相似。谷粒残物的密度在未翻耕的小麦地上最大。为了最大限度地增加黑颈鹤的冬季食物资源 ,减少人为活动对黑颈鹤的干扰 ,我们建议 :在秋收后不要翻耕河流两侧的青稞地和小麦地 ;在冬小麦种植地区 ,冬小麦应仅仅种植在主要公路两侧。 | Mary Anne Bishop 李凤山 | 2002 | 生物多样性2002，10，4： | 36 |
| 2 | Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle显示文摘Background: Exercise promotes numerous phenotypic adaptations in skeletal muscle that contribute to improved function and metabolic capacity. An emerging body of evidence suggests that skeletal muscle also releases a myriad of factors during exercise, termed 'myokines'. The purpose of this study was to examine the effects of high-intensity interval training(HIIT) on the acute regulation of the mRNA expression of several myokines, including the prototypical myokine interleukin-6(IL-6), and recently identified myokines fibronectin type III domain-containing protein 5(FNDC5)(irisin) and meteorin-like protein(METRNL).Methods: Both before and after a 20-day period of twice-daily high-volume HIIT, 9 healthy males(20.5 ± 1.5 years performed a standardized bout of high-intensity interval exercise(HIIE; 5 × 4 min at ~80% pretraining peak power output) with skeletal muscle biopsy samples(vastus lateralis) obtained at rest, immediately following exercise, and at 3 h recovery.Results: Before training, a single bout of HIIE increased IL-6(p < 0.05) and METRNL(p < 0.05) mRNA expression measured at 3 h recovery when compared to rest. Following 20 days of HIIT, IL-6 and FNDC5 mRNA were increased at 3 h recovery from the standardized HIIE bout when compared to rest(both p < 0.05). Resting METRNL and FNDC5 mRNA expression were higher following training(p < 0.05), and there was an overall increase in FNDC5 mRNA post-training(main effect of training, p < 0.05).Conclusion: In human skeletal muscle(1) an acute bout of HIIE can induce upregulation of skeletal muscle IL-6 mRNA both before and after a period of intensified HIIT;(2) Resting and overall FNDC5 mRNA expression is increased by 20 days of HIIT; and(3) METRNL mRNA expression is responsive to both acute HIIE and short-term intense HIIT. Future studies are needed to confirm these findings at the protein and secretion level in humans. | Malcolm Eaton Cesare Granata Julianne Barry Adeel Safdar David Bishop Jonathan P.Little | 2018 | Journal of Sport and Health Science2018，7，2： | 15 |
| 3 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 4 | International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas显示文摘 | Masao Tanaka Carlos Fernández-del Castillo Volkan Adsay Suresh Chari Massimo Falconi Jin-Young Jang Wataru Kimura Philippe Levy Martha Bishop Pitman C. Max Schmidt Michio Shimizu Christopher L. Wolfgang Koji Yamaguchi Kenji Yamao | 2012 | Pancreatology2012，，3： | 13 |
| 5 | 西藏黑颈鹤越冬数量统计显示文摘珍稀动物黑颈鹤(Grus nigri Collis)在西藏境内越冬数量现已查明,全世界70%的黑颈鹤在西藏越冬(近4000只),越冬聚集区在雅鲁藏布江中游西部河谷和拉萨河中下游河谷。作者认为,附加的农业措施对于黑颈鹤的保护至关重要。 | 仓曲卓玛 顾滨源 MARV ANNE BISHOP | 1994 | 西藏科技1994，，3： | 11 |
| 6 | Application and Modeling of Battery Energy Storage in Power Systems显示文摘This paper presents engineering experiences from battery energy storage system(BESS)projects that require design and implementation of specialized power conversion systems(a fast-response,automatic power converter and controller).These projects concern areas of generation,transmission,and distribution of electric energy,as well as end-energy user benefits,such as grid frequency regulation,renewable energy smoothing and leveling,energy dispatching and arbitrage,power quality and reliability improvements for connected customers,islanding operations,and smart microgrid applications.In general,a grid level BESS project sends an interconnect request to utility power grids in the project development stage.Simulation models of equipment are then sent for a system impact study(e.g.,power flow and/or stability analysis),based on utility grid code requirements.The system study then determines the connection’s technical feasibility and impact of the project on the power grid.In this paper,a set of new BESS models is presented that are configured and parameterized for use in system impact studies as well as transmission planning studies.The models,which have been recently approved and released by the U.S.Western Electricity Coordinating Council(WECC),represent the steady state and dynamic performance of the BESS in several software platforms for power system studies based on operating project performance experience.Model benchmarking results as well as a real system case study are also included in the paper to show that the parameterized and tuned models respond correctly and as expected when system operating conditions change following contingency events.Finally,this paper provides useful guidelines in the use of new models to represent a BESS for power system analysis. | Xiaokang Xu Martin Bishop Donna G.Oikarinen Chen Hao | 2016 | CSEE Journal of Power and Energy Systems2016，2，3： | 8 |
| 7 | 西藏黑颈鹤和斑头雁碰撞输电线的研究(英文)显示文摘我们在西藏自治区雅鲁藏布江河谷进行了为期两个冬季的黑颈鹤(Grus nigricollis)和斑头雁(Anserindicus)碰撞输电线路的调查。每个冬季,在一条 35 kV 的输电线路上设置 3 条样线,观察受伤和死亡的个体。受伤的个体在发现 5 天以后就不见了,而多数死亡个体的残骸发现时已经严重残缺不全。在样线调查时,记录到两只死亡的斑头雁;另外,在紧邻样线附近的地方见到两只受伤的斑头雁和两只死亡的黑颈鹤。调查发现鸟类碰撞输电线多发生在靠近夜宿和觅食地的地方。我们建议,在位于碰撞敏感区(如夜宿地、觅食地以及有农田的河谷谷口的雁鹤飞行通道)的新旧输电线路增加颜色鲜艳的标志物,以便减少鹤类和雁类的碰撞。 | 李凤山 Mary Anne BISHOP 仓决卓玛 | 2011 | Chinese Birds2011，，4： | 7 |
| 8 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 9 | SNL fibroblast feeder layers support derivation and maintenance of human induced pluripotent stem cells显示文摘Induced pluripotent stem(iPS) cells can be derived from human somatic cells by cellular reprogramming.This technology provides a potential source of non-controversial therapeutic cells for tissue repair,drug discovery,and opportunities for studying the molecular basis of human disease.Normally,mouse embryonic fibroblasts(MEFs) are used as feeder layers in the initial derivation of iPS lines.The purpose of this study was to determine whether SNL fibroblasts can be used to support the growth of human iPS cells reprogrammed from somatic cells using lentiviral expressed reprogramming factors.In our study,iPS cells expressed common pluripotency markers,displayed human embryonic stem cells(hESCs) morphology and unmethylated promoters of NANOG and OCT4.These data demonstrate that SNL feeder cells can support the derivation and maintenance of human iPS cells. | Chuanying Pan Amy Hicks Xuan Guan Hong Chen Colin E. Bishop | 2010 | Journal of Genetics and Genomics2010，37，4： | 5 |
| 10 | Why did China Benefit from a Joint Venture Policy? A Case Study of Shanghai显示文摘Mandatory joint venture requirements have played an important role in many developing countries' foreign investment policies. However,such policies have been criticized in some of the economic literatures on the grounds that they deter investment and lead to the development of inefficient industries. A significant amount of foreign direct investment in Shanghai has been in the form of joint ventures. Yet,by many measures,Shanghai has benefited enormously. This article argues that there are three reasons to explain Shanghai's successful use of the joint venture for its industrial development. First,local firms and industries have had the capability and willingness to learn from joint ventures and other foreign invested firms. Second,the joint venture policy has been more likely than not to have 'crowded in' local investment rather than crowd it out. Third,investment authorities in Shanghai have had sufficient bureaucratic capacity and political insulation to prevent the joint venture policy from being manipulated by rent seekers. | Bernard Bishop | 2007 | China & World Economy2007，15，2： | 4 |
| 11 | 利用诱导因子Oct4、Sox2和SV40T的mRNA介导体细胞重编程研究显示文摘为利用特定诱导因子Oct4、Sox2和SV40T的体外转录mRNA实现安全的成纤维细胞重编程,本研究成功构建了特定诱导因子Oct4、Sox2和SV40T的mRNA体外转录载体,并对体外转录mRNA进行了5′和3′端加工修饰;进行了诱导因子mRNA的293和IMR90细胞转染试验,利用免疫细胞化学、免疫荧光和Real-Time PCR分别检测了Oct4、Sox2、SV40T和Nanog的表达情况。结果显示,以上2种细胞以Oct4∶Sox2∶SV40T=2∶1∶1的mRNA比例转染后均表达这3种特定诱导因子,且相应蛋白都正确地定位在细胞核上。转染细胞中Oct4和Nanog的表达都特异性地增高。结果提示,3种诱导因子的体外转录mRNA能够在体内协同作用,激活细胞内源性干性标志基因Nanog的表达,为开启重编程过程奠定了坚实的基础。 | 潘传英 陈宏 BISHOP E.Colin | 2012 | 畜牧兽医学报2012，43，11： | 4 |
| 12 | Application of laser scanning for rock mass characterization and discrete fracture network generation in an underground limestone mine显示文摘Terrestrial laser scanning(TLS) is a useful technology for rock mass characterization. A laser scanner produces a massive point cloud of a scanned area, such as an exposed rock surface in an underground tunnel,with millimeter precision. The density of the point cloud depends on several parameters from both the TLS operational conditions and the specifications of the project, such as the resolution and the quality of the laser scan, the section of the tunnel, the distance between scanning stations, and the purpose of the scans. One purpose of the scan can be to characterize the rock mass and statistically analyze the discontinuities that compose it for further discontinuous modeling. In these instances, additional data processing and a detailed analysis should be performed on the point cloud to extract the parameters to define a discrete fracture network(DFN) for each discontinuity set. I-site studio is a point cloud processing software that allows users to edit and process laser scans. This software contains a set of geotechnical analysis tools that assist engineers during the structural mapping process, allowing for greater and more representative data regarding the structural information of the rock mass, which may be used for generating DFNs. This paper presents the procedures used during a laser scan for characterizing discontinuities in an underground limestone mine and the results of the scan as applied to the generation of DFNs for further discontinuous modeling. | Juan J.Monsalve Jon Baggett Richard Bishop Nino Ripepi | 2019 | International Journal of Mining Science and Technology2019，29，1： | 4 |
| 13 | Laser Repair of Steam Turbine Blades(Invited Paper)显示文摘Reliable and efficient power generation is a major global issue due to both political and environmental concerns.Nevertheless many critical components,particularly the blades of the low pressure(LP) side of power generating steam turbines,are subjected to failure due to severe erosion at the leading edges.Since taking machines off-line for maintenance and removal of damaged blade for repair is extremely expensive,increasing the service life of these critical components can offer significant economic and political benefits.Conventional techniques to increase service life include brazing of an erosion shield at the leading edge of the turbine blades,open arc hardfacing,and cladding with erosion resistant materials using gas tungsten,manual metal or plasma transferred arc welding.We have been investigating for the past eight years the potential of laser cladding to deposit a high quality and erosion resistant protection shield on the leading edge of LP blades.Laser cladding offers unique advantages over the conventional techniques.The project to-date has demonstrated the feasibility of in-situ repair of turbine blades in trials conducted at a power station using a fibre delivered Laserline diode laser and a robot.A company(Hardwear Pty.Ltd.) has been established to commercialise the technology and has delivered two commercial contracts. | M. Brandt S. Sun A. Bishop | 2009 | 中国激光2009，36，12： | 4 |
| 14 | δ-aminolevulinic acid dehydratase isozymes and lead toxicity显示文摘 | Astrin KH Bishop DF Wetmur JG | 1987 | Ann N Y Acad Sci1987，514，： | 3 |
| 15 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 16 | 子宫颈癌累及泌尿生殖道:潜在的诊断困境显示文摘Schwartz L E, Khani F, Bishop J A, et al. Carcinoma of the u- terine cervix involving the genitourinary tract: a potential diag- nostic dilemma. Am J Surg Pathol, 2016,40(1) :27 -35.有关子宫颈癌继发累及泌尿生殖道的记载非常少见。由于形态学上这些肿瘤可以类似于尿路上皮癌,也可以与膀胱的原发性鳞状细胞癌和原发性腺癌非常相似,故诊断具有极大的挑战性。作者收集了约翰霍普金斯医院从1984年至今的泌尿生殖器咨询案例,主要包括原发性膀胱癌与子宫颈癌继发性累及膀胱的鉴别诊断病例。作者确定了10例满足这些标准的病例。 | Schwartz L E Khani F Bishop J A 魏建国 许春伟 | 2016 | 临床与实验病理学杂志2016，32，2： | 3 |
| 17 | Magnetic resonance imaging of the pancreas in streptozotocin-induced diabetic rats: Gadofluorine P and Gd-DOTA显示文摘AIM: To investigate the performance of Gadofluorine P-enhanced magnetic resonance imaging(MRI) on the diagnosis of diabetes in a streptozotocin(STZ)-induced diabetic rat model.METHODS: Fischer 344 rats were treated with STZ.Rats not treated with STZ served as controls. T1-weighted MRI was performed using a 3T scanner before and after the injection of Gd-DOTA or Gadofluorine P(6 diabetic rats, 5 controls). The normalized signal intensity(SI) and the enhancement ratio(ER) of the pancreas were measured at each time point, and the values were compared between the normal and diabetic rats using the Mann-Whitney test. In addition,the values were correlated with the mean islet number.Optimal cut-off values were calculated using a positive test based on receiver operating characteristics.Intrapancreatic Gd concentration after the injection of each contrast media was measured using laser ablation-inductively coupled plasma-mass spectrometry in a separate set of rats(4 diabetic rats, 4 controls for Gadofluorine P; 2, 2 for Gd-DOTA).RESULTS: The normalized SI and ER of the pancreas using Gd-DOTA were not significantly different between diabetic rats and controls. With Gadofluorine P, the values were significantly higher in the diabetic rats than in the control rats 30 min after injection(P < 0.05). The area under the receiver operating characteristic curve that differentiated diabetic rats from the control group was greater for Gadofluorine P than for Gd-DOTA(0.967 vs 0.667, P = 0.085). An increase in normalized SI 30 min after Gadofluorine P was correlated with a decrease in the mean number of islets(r 2 = 0.510, P = 0.014). Intra-pancreatic Gd was higher in rats with Gadofluorine P injection than Gd-DOTA injection(Gadofluorine P vs Gd-DOTA, 7.37 vs 0.00, P < 0.01). A significant difference in the concentration of intrapancreatic Gd was observed between the control and diabetic animals that were sacrificed 30 min after Gadofluorine P injection(control vs diabetic, 3.25 ng/g vs 10.55 ng/g, P < 0.05)CONCLUSION: In this STZ-induced diabetes rat model,Gadofluorine P-enhanced MRI of the pancreas showed high accuracy in the diagnosis of diabetes. | Hye Rim Cho Youkyung Lee Philip Doble David Bishop Dominic Hare Young-Jae Kim Kwang Gi Kim Hye Seung Jung Kyong Soo Park Seung Hong Choi Woo Kyung Moon | 2015 | World Journal of Gastroenterology2015，21，19： | 2 |
| 18 | Diagnosis of pancreatic neoplasia with EUS and FNA: a report of accuracy显示文摘 | Brian G. Turner Sevdenur Cizginer Deepak Agarwal Jingyun Yang Martha Bishop Pitman William R. Brugge | 2010 | Gastrointestinal Endoscopy2010，，1： | 2 |
| 19 | Role of β-microseminoprotein from prostate cancer initiationto recurrence: A mini-review显示文摘Medline/Pubmed articles relevant to this topic were considered using the search terms ?-microseminoprotein, MSMB, prostate secretory protein of 94 amino acids and PSP94. Full articles were retrieved when the abstract was considered relevant. In addition, other data related to this topic including our own are discussed. Summary of fi ndings-?-microseminoprotein(MSMB) is increasingly being considered as a marker for prostatecancer, as reduced levels have been associated with the disease. Here we review various aspects of this protein including its biological and physiological variants, binding proteins and immune modulation; its importance as a marker for biochemical recurrence of prostate cancer; prostate cancer related splice variants and its therapeutic utility. Two of the most important properties of MSMB are related to anticancer functions and immune modulation. Predominant expression of two(short and full-length) splice variants of MSMB has been observed from normal prostate and several other tissues. In benign prostate hyperplasia the short isoform is dominant, constituting 98% of this isoform, whereas in prostate cancer 96% constitute the fulllength isoform. The MSMB promoter single nucleotide polymorphism rs10993994 with the C allele functions as an activated cyclic adenosine monophosphate response element binding protein binding site. This C variant of rs10993994 could be responsible for the production of splice variants under variable conditions. MSMB has binding motifs to a few known proteins including immunoglobulin G and several Cysteine-rich secretory proteins family proteins. MSMB bound to these proteins is considered as immune modulating. Use of MSMB as a urinary marker for detecting aggressive prostate cancers that could resist radiation and surgical treatments, seems possible, but needs further investigation. The ratio of MSMB splice variants could also be a possible approach in understanding prostate cancers, with higher ratios indicating severe disease. | Nishi Karunasinghe Karen Bishop Pamela Murray Yuanye Xu Megan Goudie Lance Ng Shuotun Zhu Dug Yeo Han Lynnette R Ferguson Jonathan Masters Benji Benjamin Michael Holmes | 2014 | World Journal of Clinical Urology2014，3，1： | 2 |
| 20 | A genetic linkage map for cattle显示文摘 | Michael D Bishop Steven M | 1994 | Genetics1994，136，： | 2 |
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