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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform显示文摘 | Bence Sipos Simone M?ser Holger Kalthoff Virag T?r?k Matthias L?hr Günter Kl?ppel | 2003 | Virchows Archiv2003，，5： | 4 |
| 3 | Determination of ethyl carbamate in wine by high performance liquid chromatography显示文摘 | Zsolt Ajtony Norbert Szoboszlai László Bencs Erna Viszket Victor G. Mihucz | 2013 | Food Chemistry2013，，2： | 2 |
| 4 | Seasonal and site-specific variation in vapour and aerosol phase PAHs over Flanders (Belgium) and their relation with anthropogenic activities显示文摘 | Ravindra K Bencs L Wauters E | 2006 | Atmospheric Environment2006，40，： | 1 |
| 5 | Habitat characteristics of harvest mouse nests on arable farmland显示文摘 | Bence S L Stander K Griffiths M | 2003 | Agriculture Ecosystems and Environment2003，99，： | 1 |
| 6 | Seasonal andsite-specifie variation in vapour and aerosol phase PAHs overF- landers (Belgium) and their relation with anthropogenicactivities显示文摘 | RAVINDRA K BENCS L WAUTERS E | 2006 | Atmos Environ2006，40，4： | 1 |
| 7 | Potentiation of neuronal L cal- cium channels by IGF-1 requires phosphorylation of the 1 subunit on a specific tyrosine residue 显示文摘 | Bence K K Marshall J Blair L A | 2006 | Neuronolgy2006，27，1： | 1 |
| 8 | Some solvable stochastic control problems显示文摘 | Bencs V E Sheep L A Witsenhausen H S | 1980 | Stochastics1980，4，： | 1 |
| 9 | A survey of security issues in hardware virtualization显示文摘 | PéK G BUTTYáN L BENCSáTH B | 2013 | ACM Computing Survey2013，45，3： | 1 |
| 10 | Anterior cham- ber depth measurements in phakic and pseudophakic eyes:Pen- tacam versus ultrasound device 显示文摘 | Gabor N Attila V Bence K Berta A Modis L Jr | 2006 | J Cataract Refract Surg2006，32，8： | 1 |
| 11 | Habitat characteristics of harvest mouse nests on arable farmland显示文摘 | Bence S L Stander K Griffiths M | 2003 | Agric Ecosyst Environ2003，99，13： | 1 |
| 12 | Genetic profile of 22 pancreatic carcinoma cell lines显示文摘 | Patrick S. Moore Bence Sipos Simonetta Orlandini Claudio Sorio Francisco X. Real Nicholas R. Lemoine Thomas Gress Claudio Bassi Günter Kl?ppel Holger Kalthoff Hendrik Ungefroren Matthias L?hr Aldo Scarpa | 2001 | Virchows Archiv2001，，6： | 1 |
| 13 | Seasonal and site-specific variation in vapour and aerosol phase PAHs over Flanders (Belgium) and their relation with anthropogenic activities显示文摘 | Ravindra K Bencs L Wauters E | 2006 | Atmos Envirom2006，40，： | 1 |
| 14 | Study on the simultaneous determination of some essential and toxic trace elements in honey by multi-element graphite furnace atomic absorption spectrometry 显示文摘 | Ajtony Z Bencs L Haraszi R | 2007 | Talanta2007，71，2： | 1 |
| 15 | Platinum group elements in the environment and their health risk 显示文摘 | Ravindra K Bencs L Grieken RV | 2004 | Science of the Total Environment2004，318，： | 1 |
| 16 | Determination of ethyl carbamate in wine by high performance liquid chromatography显示文摘 | AJTONYA Z SZOBOSZLAIBN BENCS L | 2013 | Food Chemistry2013，141，： | 1 |
| 17 | Citrullination under physiological and pathological conditions显示文摘 | Zsuzsanna Baka Bence Gy?rgy Pál Géher Edit I. Buzás András Falus Gy?rgy Nagy | 2012 | Joint Bone Spine2012，，5： | 1 |
| 18 | Seasonal and site-specific variation in vapour and aerosol phase PAHs over Flanders (Belgium) and their relation with anthropogenic activities 显示文摘 | Ravindra K Bencs L Wanters E | 2006 | Atmospheric Environment2006，40，4： | 1 |
| 19 | Platinum group elementsin the environment and their health risk显示文摘 | RAVINDRA K BENCS L GRIEKEN R V | 2004 | Science of the TotalEnvironment2004，318，： | 1 |
| 20 | A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform显示文摘 | Bence Sipos Simone M?ser Holger Kalthoff Virag T?r?k Matthias L?hr Günter Kl?ppel | 2003 | Virchows Archiv2003，，5： | 1 |
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