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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform显示文摘 | Bence Sipos Simone M?ser Holger Kalthoff Virag T?r?k Matthias L?hr Günter Kl?ppel | 2003 | Virchows Archiv2003，，5： | 4 |
| 3 | Determination of ethyl carbamate in wine by high performance liquid chromatography显示文摘 | Zsolt Ajtony Norbert Szoboszlai László Bencs Erna Viszket Victor G. Mihucz | 2013 | Food Chemistry2013，，2： | 2 |
| 4 | Expression and function of Toll - like receotor 2 and 4 inhuman Keratinocytes 显示文摘 | Ando P Lasil B Bence R | 2003 | International Immunology2003，15，6： | 1 |
| 5 | Impairment of the ubiquitin-proteasome system by protein aggregation 显示文摘 | BENCE N F SAMPAT R M KOPITO R R | 2001 | Science2001，292，5521： | 1 |
| 6 | Sleep and psychiatric disorders:a meta-analysis显示文摘 | Obermeyer WH Thisted RA | 1992 | Arch Gen Psychiatry1992，49，： | 1 |
| 7 | Seasonal and site-specific variation in vapour and aerosol phase PAHs over Flanders (Belgium) and their relation with anthropogenic activities显示文摘 | Ravindra K Bencs L Wauters E | 2006 | Atmospheric Environment2006，40，： | 1 |
| 8 | Environmentalstability of selected petroleum hydrocarbon source and weatheringratios显示文摘 | Douglas G S Bence A E Prince R C | 1996 | Environmental Science&Technology1996，30，7： | 1 |
| 9 | Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B显示文摘 | Delibegovic M Bence K K Mody N | 2007 | Mol Cell Biol2007，27，21： | 1 |
| 10 | The Evolution of the UK's Research Assessment Exercise: Publications, Performance and Perceptions显示文摘 | BENCE V OPPENHEIM C | 2005 | Journal of Educational Administration and History2005，37，2： | 1 |
| 11 | Melanocortin control of energy balance: evidence from rodent models显示文摘 | De Jonghe B C Hayes M R Bence K K | 2011 | Cell Mol Life Sci2011，68，15： | 1 |
| 12 | An immunoturbidimetric assay for rapid quantitative measurement of feline alpha-1-acid glycoprotein in serum and peritoneal fluid显示文摘 | Bence LM Addie DD Eckersall PD | 2005 | Vet Clin Pathol2005，34，4： | 1 |
| 13 | Space-limited recruitment in open systems:the importance of time delays显示文摘 | J R Bence R M Nisbet | 1989 | Ecology1989，，： | 1 |
| 14 | Two column lesions in the thoracolumbar junction: anterior, posterior or combined approach? A comparative biomechanical in vitro investigation 显示文摘 | Bence T Schreiber U Grupp T | 2007 | Eur Spine J2007，16，6： | 1 |
| 15 | Quantitation of doxorubicin uptake, effiux,and modulation of multidrug resistance(MDR)in MDR hu- man cancer ceils 显示文摘 | Shen F Chu S Bence AK | 2008 | J Pharmacol Exp Ther2008，324，1： | 1 |
| 16 | Phase Ⅰ pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects显示文摘 | BENCE A K ANDERSON E B HALEPOTA M A | 2005 | Invest New Drugs2005，23，1： | 1 |
| 17 | Habitat characteristics of harvest mouse nests on arable farmland显示文摘 | Bence S L Stander K Griffiths M | 2003 | Agriculture Ecosystems and Environment2003，99，： | 1 |
| 18 | Moti-on of Multiple Junctions,A Level Set Approach显示文摘 | Bence J Osher S | 1994 | Journal of Computational Physics1994，112，3： | 1 |
| 19 | Hepatic PTP1B Deficiency: the promise of a treat- ment for metabolic syndrome? 显示文摘 | Bence K K | 2010 | J Clin Metab Diabetes2010，1，1： | 1 |
| 20 | The Evolution of the UK's Research Assessment Exercise: Publications, Performance and Perceptions显示文摘 | BENCE V OPPENHEIM C | 2005 | Journal of Educational Administration and History2005，37，2： | 1 |
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