|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adjuvant chemotherapy for gastric cancer:Current evidence and future challenges显示文摘Gastric cancer still represents one of the major causes of cancer mortality worldwide.Patients survival is mainly related to stage,with a high proportion of patients with metastatic disease at presentation.Thus,the cure rate largely depend upon surgical resection.Despite the additional,albeit small,benefit of adjuvant chemotherapy has been clearly demonstrated,no general consensus has been reached on the best treatment option.Moreover,the narrow therapeutic index of adjuvant chemotherapy(i.e.,limited survival benefit with considerable toxicity)requires a careful assessment of expected risks and benefits for individual patients.Treatment choices vary widely based on the different geographic areas,with chemotherapy alone more often preferred in Europe or Asia and chemoradiotherapy in the United States.In the present review we discuss the current evidence and future challenges regarding adjuvant chemotherapy in curatively resected gastric cancer with particular emphasis on the recently completed landmark studies and meta-analyses.The most recent patient-level meta-analysis demonstrated the benefit of adjuvant chemotherapy over curative surgery;the same Authors also showed that disease free survival may be used as a surrogate end-point for overall survival.We finally discuss future research issues such as the need of economic evaluations,development of prognostic or predictive biomarkers,and the unmet clinical need of trials comparing perioperative chemotherapy with adjuvant treatment. | Rosalba Miceli Gianluca Tomasello Giacomo Bregni Maria Di Bartolomeo Filippo Pietrantonio | 2014 | World Journal of Gastroenterology2014，20，16： | 12 |
| 2 | Role of MGMT as biomarker in colorectal cancer显示文摘O6-methylguanine DNA methyltransferase(MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients. | Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio | 2014 | World Journal of Clinical Cases2014，2，12： | 10 |
| 3 | Activity of tea tree oil and nerolidol alone or in combination against Pediculus capitis (head lice) and its eggs显示文摘 | Emanuela Campli Soraya Bartolomeo Patricia Delli Pizzi Mara Giulio Rossella Grande Antonia Nostro Luigina Cellini | 2012 | Parasitology Research2012，，5： | 2 |
| 4 | An unusual case of fatty liver in a patient with desmoid tumor显示文摘A desmoid tumor,also known as aggressive fibromatosis,is a rare benign neoplasm that arises from fascial or musculoaponeurotic tissues.It can occur in any anatomical location,most commonly the abdominal wall,shoulder girdle and retroperitoneum.The typical clinical presentation is a painless mass with a slow and progressive invasion of contiguous structures.It is associated with a high local recurrence rate after resection.Many issues regarding the optimal treatment of desmoid tumors remain controversial.Aggressive surgical resection with a wide margin(2-3 cm) remains the gold standard treatment with regard to preserving quality of life.Radiotherapy alone has been shown to be effective for the control of unresectable or recurrent lesions.Desmoid tumors tend to be locally infiltrative,therefore,the fields must be generous to prevent marginal recurrence.The radiation dose appropriate for treating desmoid tumors remains controversial.We present a 25-year-old Caucasian man with local recurrence of a desmoid tumor after repeated surgical resection,treated with radiotherapy.The patient achieved complete tumor regression at 4 mo after radiotherapy,and he is clinically free of disease at 12 mo after the end of treatment,with an acceptable quality of life.The patient developed short bowel syndrome as a complication of second surgical resection.Consequently,radiotherapy might have worsened an already present malabsorption and so led to steatohepatitis. | Francesca De Felice Daniela Musio Rossella Caiazzo Bartolomeo Dipalma Lavinia Grapulin Camilla Proietti Semproni Vincenzo Tombolini | 2012 | World Journal of Gastroenterology2012，18，24： | 2 |
| 5 | Interplay between SOX9, β-catenin and PPARγ activation in colorectal cancer显示文摘 | Anna Panza Valerio Pazienza Maria Ripoli Giorgia Benegiamo Annamaria Gentile Maria Rosaria Valvano Bartolomeo Augello Giuseppe Merla Clelia Prattichizzo Francesca Tavano Elena Ranieri Pierluigi di Sebastiano Manlio Vinciguerra Angelo Andriulli Gianluigi M | 2013 | BBA - Molecular Cell Research2013，，8： | 2 |
| 6 | Long-term results of survival in patients with thalassemia major treated with bone marrow transplantation 显示文摘 | Di Bartolomeo P Santarone S Di Bartolomeo E | 2008 | Am J Hematol2008，83，7： | 1 |
| 7 | Genotoxicity of al-kene epoxides in human peripheral blood mononuclear cells and HL60 leukaemia cells evaluated with the comet assay 显示文摘 | Fabiani R Rosignoli P De Bartolomeo A | 2012 | Mutat Res2012，747，1： | 1 |
| 8 | Clinical and Immunological Impact of Early Postoperative Enteral Immunonutrition After Total Gastrectomy in Gastric Cancer Patients: A Prospective Randomized Study显示文摘 | Luigi Marano Raffaele Porfidia Modestino Pezzella Michele Grassia Marianna Petrillo Giuseppe Esposito Bartolomeo Braccio PierLuigi Gallo Virginia Boccardi Angelo Cosenza Giuseppe Izzo Natale Di Martino | 2013 | Annals of Surgical Oncology2013，，12： | 1 |
| 9 | Phase Ⅱ study of the etoposide,leucovorin and fluorouracil combination for patients with advanced gastric cancer unsuitable for aggressive chemotherapy显示文摘 | Di Bartolomeo M Bajetta E de Braud F | 1995 | Oncology1995，52，： | 1 |
| 10 | Methods of cerebral protection in surgery of the thoracic aorta 显示文摘 | Pacini D Di Marco L Di Bartolomeo R | 2006 | Expert Rev Card- iovasc Ther2006，4，1： | 1 |
| 11 | A new way to treat forearm post-traumatic non-union in young patients with intramedullary nailing and platelet-rich plasma显示文摘 | Memeo A Verdoni F De Bartolomeo O | 2014 | Injury2014，45，： | 1 |
| 12 | Arch replacement and downstream stent grafting in complex aortic dissection: first results of an international registry ☆显示文摘 | Konstantinos Tsagakis Davide Pacini Roberto Di Bartolomeo Jaroslav Benedik Stepan Cerny Michael Gorlitzer Martin Grabenwoger Carlos A. Mestres Heinz Jakob | 2011 | European Journal of Cardio-Thoracic Surgery2011，，1： | 1 |
| 13 | Left unilat eral neglect as a disconnection syndrome显示文摘 | Bartolomeo P Thiebaut De Schotten M Doricchi F | 2007 | Cerebral Cortex2007，17，11： | 1 |
| 14 | Comparison of somatostatin receptor imaging, computed tomography and ultrasound in the clinical management of neuroendocrine gastro-entero-pancreatic tumours显示文摘 | Arturo Chiti Stefano Fanti Giordano Savelli Annadina Romeo Bartolomeo Bellanova Marcello Rodari Barbara J. van Graafeiland Nino Monetti Emilio Bombardieri | 1998 | European Journal of Nuclear Medicine1998，，10： | 1 |
| 15 | Influence of culture conditions on the DNA-damaging effect of benzene and its metabolites in human peripheral blood mononllclear cells显示文摘 | Fabiani R DE Bartolomeo A Rosiglloli P | 2001 | Environ Mol Mutagen2001，37，1： | 1 |
| 16 | The effect of a silver nanoparticle polysaccharide system on streptococcal and saliva-derived biofilms 显示文摘 | Di Giulio M Di Bartolomeo S Di Campli E | 2013 | Int J Mol Sci2013，14，13： | 1 |
| 17 | Raltitrexed plus oxaliplatin in the treatment of metastatic colorectal cancer 显示文摘 | Cortinovis D Bajetta E Di Bartolomeo M | 2004 | Tumori2004，90，2： | 1 |
| 18 | Randomized phase Ⅱ noncomparative trial of oral and intravenous doxifluridine plus levo-leucovorin in untreated patients with advanced colorectal carcinoma显示文摘 | Bajetta E Di Bartolomeo M Somma L | 1996 | Cancer1996，78，10： | 1 |
| 19 | Randomized multicenter phase Ⅱ trial of two different schedules of irinotecan com- bined with capecitabine as first - line treat- ment in metastatic colorectal carcinoma 显示文摘 | Bajetta E Di Bartolomeo M Mariani L | 2004 | Cancer2004，100，2： | 1 |
| 20 | Use of the Valsalva graft and long-term follow-up显示文摘 | Ruggero De Paulis Raffaele Scaffa Saverio Nardella Daniele Maselli Luca Weltert Fabio Bertoldo Davide Pacini Fabrizio Settepani Giuseppe Tarelli Roberto Gallotti Roberto Di Bartolomeo Luigi Chiariello | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员