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| 1 | Acute necrotizing pancreatitis as fi rst manifestation of primary hyperparathyroidism显示文摘We report the case of a female patient with severe acute necrotizing pancreatitis associated with hypercalcemia as first manifestation of primary hyperparathyroidism caused by a benign parathyroid adenoma.Initially the acute pancreatitis was treated conservatively.The patient subsequently underwent surgical resection of the parathyroid adenoma and surgical clearance of a large infected pancreatic pseudocyst.Although the association of parathyroid adenoma-induced hypercalcemia and acute pancreatitis is a known medical entity,it is very uncommon.The pathophysiology of hypercalcemia-induced acute pancreatitis is therefore not well known,although some mechanisms have been proposed.It is important to treat the provoking factor.Therefore,the cause of hypercalcemia should be identif ied early.Surgical resection of the parathyroid adenoma is the ultimate therapy. | Jeroen I Lenz Jimmy M Jacobs Bart Op de Beeck Ivan A Huyghe Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，23： | 9 |
| 2 | New insights into the regulation of cholesterol eft from the sperm membrane显示文摘 | Tamara Leahy Bart M Gadella | 2015 | Asian Journal of Andrology2015，17，4： | 5 |
| 3 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 4 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 5 | Characterization of genetically engineered mouse models carrying Col2a1-cre-induced deletions of Lrp5 and/or Lrp6显示文摘Mice carrying Collagen2a1-cre-mediated deletions of Lrp5 and/or Lrp6 were created and characterized.Mice lacking either gene alone were viable and fertile with normal knee morphology.Mice in which both Lrp5 and Lrp6 were conditionally ablated via Collagen2al-cre-mediated deletion displayed severe defects in skeletal development during embryogenesis.In addition,adult mice carrying Collagen2al-cre-mediated deletions of Lrp5 and/or Lrp6 displayed low bone mass suggesting that the Collagen2a1-cre transgene was active in cells that subsequently differentiated into osteoblasts.In both embryonic skeletal development and establishment of adult bone mass,Lrp5 and Lrp6 carry out redundant functions. | Cassie A Schumacher Danese M Joiner Kennen D Less Melissa Oosterhouse Drewry Bart O Williams | 2015 | Bone Research2015，3，4： | 3 |
| 6 | Increased Prevalence of Coronary Artery Aneurysms Among Cocaine Users显示文摘 | Aaron Satran Bradley A. Bart Christopher R. Henry M Bilal Murad Sumaiya Talukdar Daniel Satran Timothy D. Henry | 2005 | Circulation2005，，： | 2 |
| 7 | Resistance to first line platinum paclitaxel chemotherapy in serousepithelial ovarian cancer: The prediction value of ERCC1 and Tau expression显示文摘 | Karina Steffensen Marta Smoter Marianne Waldstr?m Bart?omiej Grala Lubomir Bodnar Rafa? Stec Cezary Szczylik Anders Jakobsen | 2014 | International Journal of Oncology2014，，5： | 2 |
| 8 | Electric micromotor dynamics显示文摘 | Bart S F Mehregany M Tavrow L S | 1992 | IEEE Transactions on Electron Devices1992，39，3： | 1 |
| 9 | A genetic input selection methodology for identification of the cleaning process on a combine harvester,Part Ⅱ:selection of relevant input variables for identification of material other than grain (MOG)content in the grain bin显示文摘 | Geert C Wouter S Bart M | | 0，，： | 1 |
| 10 | Regulatory role of SGTI in early R Gene-Mediated plant defenses显示文摘 | Mark J Paul M Katherine K Bart J Jonathan D G Jane E | 2002 | Science2002，295，15： | 1 |
| 11 | Constraint satisfaction tech-niques in planning and scheduling显示文摘 | Bart仳k R Salido M A Rossi F | | 0，，1： | 1 |
| 12 | Identification of the cleaning process on combine harvesters,part II:a fuzzy model for prediction of the sieve losses显示文摘 | Geert C Wouter S Bart M | | 0，，02： | 1 |
| 13 | Geographic distribution of vacA allelic types of Helicobacter pylori显示文摘 | Leen–Jan Van Doorn Céu Figueiredo Francis Mégraud Salvador Pena Peter Midolo Dulciene Maria De Magalh?es Queiroz Fátima Carneiro Bart Vanderborght Maria Da Glória F. Pegado Ricardo Sanna Wink De Boer Peter M. Schneeberger Pelayo Correa Enders K.W. Ng John | 1999 | Gastroenterology1999，，4： | 1 |
| 14 | A genetic input selection methodology for identification of the cleaning process on a combine harvester,Part I:Selection of relevant input variables for identification of the sieve losses显示文摘 | Geert C Wouter S Bart M | | 0，，02： | 1 |
| 15 | Recent advances and application in the field of short-term traffic forecasting显示文摘 | van Arem Bart Kirby Howard R Van Der Vlist Martie J M | 1997 | International Journal of Forecasting1997，13，： | 1 |
| 16 | New data on enantiomeric excess versus conversion during enantioselective hydrogenation of activated ketones on a platinum catalyst显示文摘 | Balázsik K Bartók M | | 0，，2： | 1 |
| 17 | Heuristic methods for estima- ting the generalized vertex median of a weighted graph显示文摘 | TEITZ M B BART P | 1968 | Operations Research1968，16，： | 1 |
| 18 | Modeling of induced anisotropic damage in granites显示文摘 | SHAO J F HOXHA D BART M | 1999 | International Journal of Rock Mechanics and Mining Sciences1999，36，8： | 1 |
| 19 | Improved ruthenium catalysts for the modifed friedlaender quinoline synthesis显示文摘 | Hans V M Nele L Bart A | 2007 | New J Chem2007，31，： | 1 |
| 20 | GPU-accelerated elastic 3D image registration for intra-surgical applications显示文摘 | Daniel Ruijters Bart M ter Haar Romeny Paul Suetens | | 0，，02： | 1 |
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