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| 1 | Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome显示文摘Diffuse intestinal ganglioneuromatosis is a hamartomatous polyposis characterized by a disseminated, intramural or transmural proliferation of neural elements involving the enteric plexuses. It has been associated with MEN Ⅱ, neurofibromatosis type 1 and hamartomatous polyposis associated with phosphatase and tensin homolog mutation. We report the case of a female patient with a history of a breast and endometrial tumor who presented in a colonoscopy performed for rectal bleeding diffuse ganglioneuromatosis, which oriented the search for other characteristic findings of Cowden syndrome given the personal history of the patient. The presence of an esophagogastric polyposis was also noted. Cowden syndrome is characterized by skin lesions, but it is rarely diagnosed by these lesions, because they are usually overlooked. Intestinal polyposis is not a major diagnostic criterion but it is very useful for early diagnosis. The combination of colonic polyposis and glucogenic acanthosis should orient the diagnosis to Cowden syndrome. | Maria Teresa Herranz Bachiller Jesus Barrio Andrés Fernando Pons Noelia Alcaide Suárez Rafael Ruiz-Zorrilla Lorena Sancho del Val Sara Lorenzo Pelayo Carlos De La Serna Higuera Ramon Atienza Sánchez Manuel Perez Miranda | 2013 | World Journal of Gastrointestinal Oncology2013，5，2： | 5 |
| 2 | Second-line Therapy With Levofloxacin After Failure of Treatment to Eradicate Helicobacter pylori Infection: Time Trends in a Spanish Multicenter Study of 1000 Patients显示文摘 | Javier P. Gisbert ángeles Pérez-Aisa Fernando Bermejo Manuel Castro-Fernández Pedro Almela Jesús Barrio ángel Cosme Inés Modolell Felipe Bory Miguel Fernández-Bermejo Luis Rodrigo Jesús Ortu?o Pilar Sánchez-Pobre Sam Khorrami Alejandro Franco Albert Tomas | 2013 | Journal of Clinical Gastroenterology2013，，2： | 5 |
| 3 | Adalimumab in prevention of postoperative recurrence of Crohn's disease in high-risk patients显示文摘AIM:To evaluate the effectiveness of adalimumab in preventing recurrence after intestinal resection for Crohn's disease in high-risk patients.METHODS:A multicenter,prospective,observational study was conducted from June 2009 until June 2010.We consecutively included high-risk Crohn's disease patients who had undergone an ileal/ileocolonic resection.High-risk patients were defined as two or more criteria:smokers,penetrating pattern,one or more previous surgical resections or prior extensive resection.Subcutaneous adalimumab was administered 2 wk(± 5 d) after surgery at a dose of 40 mg eow,with an initial induction dose of 160/80 mg at weeks 0 and 2.Demographic data,previous and concomitant treatments(antibiotics,5-aminosalicylates,corticosteroids,immunomodulators or biologic therapies),smoking status at the time of diagnosis and after the index operation and number of previous resections(type and reason for surgery) were all recorded.Biological status was assessed with C-reactive protein,erythrocyte sedimentation rate and fecal calprotectin.One year(± 3 mo) after surgery,an ileocolonoscopy and/or magnetic resonance enterography was performed.Endoscopic recurrence was defined as Rutgeerts score ≥ i2.Morphological recurrence was based on magnetic resonance(MR) score ≥ MR1.RESULTS:Twenty-nine patients(55.2% males,48.3% smokers at diagnosis and 13.8% after the index operation),mean age 42.3 years and mean duration of the disease 13.8 years were included in the study.A mean of 1.76(range:1-4) resections previous to adalimumab administration and in 37.9% was considered extensive resection.51.7% had previously received infliximab.Immunomodulators were given concomitantly to 17.2% of patients.Four of the 29(13.7%) developed clinical recurrence,6/29(20.7%) endoscopic recurrence and 7/19(36.8%) morphological recurrence after 1-year.All patients with clinical recurrence showed endoscopic and morphological recurrence.A high degree of concordance was found between clinical-endoscopic recurrence(k = 0.76,P < 0.001) and clinical-morphological recurrence(k = 0.63,P = 0.003).Correlation between endoscopic and radiological findings was good(comparing the 5-point Rutgeerts score with the 4-point MR score,a score of i4 was classified as MR3,i3 as MR2,and i2-i1 as MR1)(P < 0.001,r s = 0.825).During follow-up,five(17.2%) patients needed adalimumab dose intensification(40 mg/wk);Mean time to intensification after the introduction of adalimumab treatment was 8 mo(range:5 to 11 mo).In three cases(10.3%),a biological change was needed due to a worsening of the disease after the dose intensification to 40 mg/wk.One patient suffered an adverse event.CONCLUSION:Adalimumab seems to be effective and safe in preventing postoperative recurrence in a selected group of patients who had undergone an intestinal resection for their CD. | Mariam Aguas Guillermo Bastida Elena Cerrillo Belén Beltrán Marisa Iborra Cristina Sánchez-Montes Fernando Muoz Jesús Barrio Sabino Riestra Pilar Nos | 2012 | World Journal of Gastroenterology2012，18，32： | 3 |
| 4 | Peptidomic analysis of whey protein hydrolysates and prediction of their antioxidant peptides显示文摘Enzymatic hydrolysis of proteins is a breakdown process of peptide bond in proteins,releasing some peptides with potential biological functions.Previous studies on enzymatic hydrolysis of whey proteins have not identified the complete peptide profiles after hydrolysis.In this study,we reconstructed a profile of peptides from whey hydrolysates with two enzymes and different processing conditions.We also developed an ensemble machine learning predictor to classify peptides obtained from whey hydrolysis.A total of 2572 peptides were identified over three process conditions with two enzymes in duplicate.499 peptides were classified and chosen as potential antioxidant peptides from whey proteins.The peptides classified as antioxidants in the hydrolysates had a proportion of 13.1%-24.5%regarding all peptides identified.These results facilitate the selection of promising peptides involved in the antioxidant properties during the enzymatic hydrolysis of whey proteins,aiding the discovery of novel antioxidant peptides. | Jesus Morales García Chibuike C.Udenigwe Jorge Duitama Andrés Fernando González Barrios | 2022 | Food Science and Human Wellness2022，11，2： | 3 |
| 5 | Acid activation of a palygorskite with HCl:development of physico-chemical,textural and surface properties显示文摘 | BARRIOS M S GONZALEZ F VICENTE-RODRIGUEZ M A | 1995 | Appl Clay Sci1995，30，10： | 2 |
| 6 | Textural and structural modifications of saponite from Cerro del Aguila by acid treatment 显示文摘 | BARRIOS M S BUEY C S ROMERO E G | 2001 | Clay Miner2001，36，： | 2 |
| 7 | Foreign direct investment,competition and industrial development in the host country显示文摘 | BARRIOS S GORG H STROBL E | 2005 | European Economic Review2005，49，7： | 1 |
| 8 | A randomized trial of recombinant staphylokinase versus alteplase for coronary artery patency in acute myocardial infarction显示文摘 | Vanderschueren S Barrios L Kerdsinchai P | 1995 | Circulation1995，92，8： | 1 |
| 9 | Treatment and outcomes of severe cardiac disease with surgical indication in very old patients显示文摘 | Martinez-Sellés M Hortal J Barrio JM | | 0，，01： | 1 |
| 10 | Neurodegeneration is associated to changes in serum insulin-like growth factors显示文摘 | BUSIGUINA S FERNANDEZ A M BARRIOS V | 2000 | Neurobiol Dis2000，7，6： | 1 |
| 11 | A generalized height-diameter model including random components for radiata pine plantations in northwestern Spain显示文摘 | Castedo Dorado F Diéguez-Aranda(U) Barrio Anta M Sánchez Rodríguez M Gadow KV | | 0，，： | 1 |
| 12 | Surgical treatment of the radial nerve lesions associated with frac- tures of the humerus 显示文摘 | Amillo S Barrios RH Martinez-Peric R | 1993 | J Orthop Trauma1993，7，3： | 1 |
| 13 | Helicobacter pylori and immunoganetic factors of the host:relevance of the HLADQA1 * 0102 and * 0301 alleles in peptic ulcer显示文摘 | Barrios Y Benito R | 2001 | Gastroenterol Hepatol2001，24，3： | 1 |
| 14 | Rapid identification of wine yeast species based on RFLP analysis of the ribosomal internal transcribed spacer (ITS) region显示文摘 | GUILLAMON J S SABATE J BARRIO E | 1998 | Arch Microbiol1998，69，5： | 1 |
| 15 | Acid activa- tion of a palygorskite with HCI: development of physico--chemical, textural and surface properties 显示文摘 | BARRIOS M S GONZALEZL V F RODRIGUEZM A V | 1995 | Appl Clay Sci1995，10，： | 1 |
| 16 | Natural antioxidants and vaseular calcification : a possible benefit 显示文摘 | Roman - Gareia P Barrio - Vazquez S Fernandez - Martin JL | 2011 | J Nephro12011，24，6： | 1 |
| 17 | Foreign direct investment,competition and industrial development in the host country显示文摘 | Barrios S G?rg H Strobl E | 2005 | European Economic Review2005，49，7： | 1 |
| 18 | Acid activation of a palygorskite with HCI: development of physi- co- chemical, textural and surface properties 显示文摘 | Barrios M S Gonzalez L V F Rodriguez M A V | 1995 | Applied Clay Science1995，10，3： | 1 |
| 19 | CD63 Tetraspanin slows down cell migration and translocates to the endosomal/lysosomal/MIICs route after extracellular stimuli in human immature dendritic cells显示文摘 | Mantegazza AR Barrio MM Moutel S | 2004 | Blood2004，104，： | 1 |
| 20 | A randomized trial of recombinant staphylokinase versus alteplmase for coronary artery patency in acute myocardial infarction显示文摘 | Vanderschueren S Barrios L Kerdsinchai P | 1995 | Circulation1995，92，： | 1 |
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