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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | Chemotherapy of glioblastoma in rats using doxorubicin - loaded nanoparticles显示文摘Glioblastomas belong to the most aggressive human cancers with short survival times.Due to the blood-brainbarrier,they are mostly inaccessible to traditional chemotherapy.We have recently shown that doxorubicin boundto polysorbate-coated nanoparticles crossed the intact blood-brain barrier,thus reaching therapeutic concentra-tions in the brain.Here,we investigated the therapeutic potential of this formulation of doxorubicin in vivo using ananimal model created by implantation of 101/8 glioblastoma tumor in rat brains.Groups of 5-8 glioblastoma- | Steiniger SC Kreuter J Khalansky AS Skidan IN Bobruskin I Smirnova ZS Severin SE Uhl R Kock M Geiger KD Gelperina SE | 2004 | 中国神经肿瘤杂志2004，2，1： | 13 |
| 3 | Accuracy of clinical diagnosis of idiopathic Parkinson's disease:a clinicopathologic study of 100 cases显示文摘 | Hughes A J Daniel SE Kilford L | 1992 | J Neurol Neurosurg Psychiatry1992，55，3： | 10 |
| 4 | Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender显示文摘AIM: To investigate age-and gender-related differences in non-culprit versus culprit coronary vessels assessed with virtual histology intravascular ultrasound (VH-IVUS). METHODS: In 390 patients referred for coronary angiography to a single center (Luzerner Kantonsspital, Switzerland) between May 2007 and January 2011, 691 proximal vessel segments in left anterior descending, circumflex and/or right coronary arteries were imaged by VH-IVUS. Plaque burden and plaque composition(fibrous, fibro-fatty, necrotic core and dense calcium volumes) were analyzed in 3 age tertiles, according to gender and separated for vessels containing non-culprit or culprit lesions. To classify as vessel containing a culprit lesion, the patient had to present with an acute coronary syndrome, and the VH-IVUS had to be performed in a vessel segment containing the culprit lesion according to conventional coronary angiography. RESULTS: In non-culprit vessels the plaque burden increased significantly with aging (in men from 37% ± 12% in the lowest to 46% ± 10% in the highest age tertile, P < 0.001; in women from 30% ± 9% to 40% ± 11%, P < 0.001); men had higher plaque burden than women at any age (P < 0.001 for each of the 3 age tertiles). In culprit vessels of the lowest age tertile, plaque burden was significantly higher than that in non- culprit vessels (in men 48% ± 6%, P < 0.001 as compared to non-culprit vessels; in women 44% ± 18%, P = 0.004 as compared to non-culprit vessels). Plaque burden of culprit vessels did not significantly change during aging (plaque burden in men of the highest age tertile 51% ± 9%, P = 0.523 as compared to lowest age tertile; in women of the highest age tertile 49% ± 8%, P = 0.449 as compared to lowest age tertile). In men, plaque morphology of culprit vessels became increasingly rupture-prone during aging (increasing percentages of necrotic core and dense calcium), whereas plaque morphology in non-culprit vessels was less rupture-prone and remained constant during aging. In women, necrotic core in non-culprit vessels was very low at young age, but increased during aging resulting in a plaque morphology that was very similar to men. Plaque morphology in culprit vessels of young women and men was similar. CONCLUSION: This study provides evidence that age-and gender-related differences in plaque burden and plaque composition significantly depend on whether the vessel contained a non-culprit or culprit lesion. | Andreas W Schoenenberger Nadja Urbanek Stefan Toggweiler Andreas E Stuck Thérèse J Resink Paul Erne | 2013 | World Journal of Cardiology2013，5，3： | 7 |
| 5 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 6 | 未控制高血压患者进行家庭血压监测与药剂师管理后的心血管事件及费用显示文摘未控制高血压是心血管病的主要病因。在16家初级保健诊所进行的整群随机试验结果表明:12个月的远程家庭血压监测与药剂师管理可较常规治疗24个月降压幅度更大。该文报道心血管事件(非致死性心肌梗死、非致死性脑卒中、心力衰竭住院、冠状动脉再血管化及心血管病死亡)与随访5年的花费。在远程干预组(TI组,n=228),10例患者发生15次心血管事件(5次心肌梗死、4次脑卒中、5次心力衰竭、1次心血管病死亡)。 | 赵狄(摘译) 刘莉(审校) Margolis KL Dehmer SP Sperl-Hillen J O’Connor PJ Asche SE Bergdall AR Green BB Nyboer RA Pawloski PA Trower NK Maciosek MV | 2020 | 中华高血压杂志2020，28，11： | 3 |
| 7 | 少量无机硝酸盐或甜菜根可有效抑制盐诱发的血压升高显示文摘为降低盐诱发高血压的风险,医学专家强调的膳食指南是促进高钾低钠摄入以使钾钠摩尔比≥1∶1。然而过去几十年间,几乎没人改变他们的膳食习惯以充分满足推荐的膳食钠钾目标。因此,降低盐诱发高血压的风险又不要求改变主要膳食习惯的新策略具有相当大的医学意义。该研究在一个广泛应用的盐诱发高血压模型Dahl盐敏感性大鼠中,发现补充硝酸盐与钠的摩尔比约为1∶170时,补充膳食硝酸盐摄入可以抑制盐诱发高血压的形成。 | 赵狄 练桂丽 Morris RC Jr Pravenec M ■ J DiCarlo SE Kurtz TW | 2019 | 中华高血压杂志2019，27，6： | 3 |
| 8 | 有氧运动联合阻抗运动对难治性高血压患者动态血压的降低作用更为持久:一项随机交叉试验显示文摘该研究比较有氧运动、阻抗运动及联合运动对难治性高血压(refractory hypertension,RH)和非难治性高血压(NON-RH)患者血压的短期影响。方法:招募患者20例(RH 10例和NON-RH 10例),随机进行三种运动训练或对照训练。试验训练结束后监测24h动态血压。结果:RH患者在有氧运动、阻抗运动及联合运动后动态血压降低。联合运动后日间和夜间动态血压均降低。有氧运动对日间血压的影响更为显著,而阻抗运动降低夜间血压的幅度较大。仅阻抗运动降低NON-RH患者的收缩压,三种运动均可降低舒张压。 | 袁源(摘译) 练桂丽(审校) Pires NF Coelho-Júnior HJ Gambassi BB deFaria APC Ritter AMV de Andrade Barboza C Ferreira-Melo SE Rodrigues B Júnior HM | 2021 | 中华高血压杂志2021，29，1： | 2 |
| 9 | Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growth显示文摘 | Pike SE Yao L Setsuda J | 1999 | Blood1999，94，7： | 2 |
| 10 | Elevated day 3 FSH/LH ratio due to low LH concentrations predicts reduced ovarian response显示文摘 | A Shrim SE Elizur DS Seidman J Rabinovici A Wiser J Dor | 2006 | Reproductive BioMedicine Online2006，，4： | 2 |
| 11 | Reliability and validity of estimating the NIH stroke scale from medical records显示文摘 | Kasner SE Chalela JA Luciano J M | 1999 | Stroke1999，30，8： | 1 |
| 12 | How do I perform a lumbar puncture and analyze the results to diagnose bacterial meningitis? 显示文摘 | Straus SE Thorpe KE Holroyd-Leduc J | 2006 | JAMA2006，296，16： | 1 |
| 13 | Warfarin vs aspirin for symptomatic intracranial stenosis:subgroup analyses from WASID显示文摘 | Lynn M J Chimowitz MI | 2006 | Neurology2006，67，： | 1 |
| 14 | Infection and atherosclerosis:emerging mechanistic paradigms显示文摘 | Epstein SE Zhou YF Zhu J | 1999 | Circulation1999，100，： | 1 |
| 15 | Epidermiological and clinical aspects of invasive group A streptococcal infections and the streptococcal toxic shock syndrome显示文摘 | Eriksson BKG Andersson J Holm SE | 1998 | Clin Infect Dis1998，27，6： | 1 |
| 16 | Circulating angiogenic factors and the risk of reeclampsia显示文摘 | Levine R J Maynard SE Qian C | 2004 | N Engl J Med2004，350，11： | 1 |
| 17 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 18 | Guidelines for the diagnosis and management ofaplastic anemia显示文摘 | Marsh JC Ball SE Cavenagh J | 2009 | Br J Haematol2009，147，： | 1 |
| 19 | Effect of sitagliptin plus metformin on beta-cell function, islet integrity and islet gene expression in Zucker diabetic fatty rats显示文摘 | Hart S J Choi SE Kang Y | 2011 | Diabetes Res Clin Pract2011，92，2： | 1 |
| 20 | Elucidating the spread of the emerging canid nematode Angiostrongylus vasorum between Palaearctic and Nearctic ecozones显示文摘 | Jefferies R Shaw SE Willesen J et 01 | 2010 | Infect Genet Evol2010，10，4： | 1 |
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