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| 1 | 1544例乳腺浸润性导管癌临床特点和生存率的多因素分析显示文摘目的 分析乳腺浸润性导管癌的临床特点和预后因素。方法 1 544 例浸润性导管癌全部为九十年代新发病例。采用观察生存率、死亡危险比、Log rank检验和拟合多因素Cox比例风险回归模型等进行单因素和多因素分析,评估各种预后因素与乳腺癌的联系强度。结果 浸润性导管癌占女性乳腺癌的82.5%,腋淋巴结转移率44.2%。外上象限发病最多,占47.7%。肿块位中央区,腋淋巴结阳性率最高,占61.7%。Ⅰ、Ⅱ、Ⅲ、Ⅳ期病例分别占30.0%,59.4%,9.4%,1.2%;5年和10年生存率分别为94.9%,78.1%;48.1%,8.6%和87.2%,67.1%;31.2%,0.0%。单因素分析:发病年龄、肿块大小、腋淋巴结转移数、TNM分期、治疗方式与生存率有关;ER、PR、Her- 2/neu、手术类型与生存率无关。多因素分析显示:发病年龄、腋淋巴结转移数、治疗方式与生存率有关。结论 腋淋巴结状况是制定治疗方案和评估预后的最主要指标。50 岁以下发病的患者以及接受综合治疗的患者生存率较高。九十年代与八十年代相比,上海市区女性乳腺癌的诊治水平有了较大的提高。 | 高道利 王文婉 郁领娣 胡永伟 陆重志 David B.Thomas Roberta M.Ray Peggy Porter | 2005 | 肿瘤2005，25，2： | 8 |
| 2 | Physiological and Growth Responses of C_3 and C_4 Plants to Reduced Temperature When Grown at Low CO_2 of the Last Ice Age显示文摘During the last ice age,CO2 concentration (CO2 ) was 180-200 μmol/mol compared with the modern value of 380 μmol/mol,and global temperatures were ~8 ·°C cooler.Relatively little is known about the responses of C3 and C4 species to long-term exposure to glacial conditions.Here Abutilon theophrasti Medik.(C3) and Amaranthus retroflexus L.(C4) were grown at 200 μmol/mol CO2 with current (30/24 °C) and glacial (22/16 °C) temperatures for 22 d.Overall,the C4 species exhibited a large growth advantage over the C3 species at low CO2.However,this advantage was reduced at low temperature,where the C4 species produced 5× the total mass of the C3 species versus 14× at the high temperature.This difference was due to a reduction in C4 growth at low temperature,since the C3 species exhibited similar growth between temperatures.Physiological differences between temperatures were not detected for either species,although photorespiration/net photosynthesis was reduced in the C3 species grown at low temperature,suggesting evidence of improved carbon balance at this treatment.This system suggests that C4 species had a growth advantage over C3 species during low CO2 of the last ice age,although concurrent reductions in temperatures may have reduced this advantage. | Joy K.Ward David A.Myers Richard B.Thomas | 2008 | Journal of Integrative Plant Biology2008，50，11： | 5 |
| 3 | Barley adaptation and improvement in the Mediterranean basin显示文摘 | A.Pswarayi F. A.Van Eeuwijk S.Ceccarelli S.Grando J.Comadran J. R.Russell E.Francia N.Pecchioni O.Li Destri T.Akar A.Al‐Yassin A.Benbelkacem W.Choumane M.Karrou H.Ouabbou J.Bort J. L.Araus J. L.Molina‐Cano W. T. B.Thomas I.Romagosa | 2008 | Plant Breeding2008，，6： | 1 |
| 4 | Risks of biliary tract cancer and occupational exposures among Shanghai women textile workers: A case‐cohort study显示文摘 | Chin‐KuoChang GeorgeAstrakianakis David B.Thomas Noah S.Seixas Janice E.Camp Roberta M.Ray DaoLi Gao Karen J.Wernli WenjinLi E. DawnFitzgibbons Thomas L.Vaughan HarveyCheckoway | 2006 | Am J Ind Med2006，，8： | 1 |
| 5 | Development of a model for evaluating the effects of environmental temperature and thermal behaviour on biological control of locusts and grasshoppers using pathogens显示文摘 | Justine I.Klass SimonBlanford Matthew B.Thomas | 2007 | Agricultural and Forest Entomology2007，，3： | 1 |
| 6 | Ultraviolet‐B‐induced stress and changes in gene expression in Arabidopsis thaliana: role of signalling pathways controlled by jasmonic acid, ethylene and reactive oxygen species显示文摘 | S.A.‐H.‐Mackerness S. L.Surplus P.Blake C. F.John V.Buchanan‐Wollaston B. R.Jordan B.Thomas | 2002 | Plant, Cell & Environment2002，，11： | 1 |
| 7 | Impact of Excess Auditor Remuneration on the Cost of Equity Capital around the World显示文摘 | Ole-Kristian Hope Tony Kang Wayne B.Thomas Yong Keun Yoo | | 0，，： | 1 |
| 8 | Managerial Empire Building and Firm Disclosure显示文摘 | OLE‐KRISTIANHOPE WAYNE B.THOMAS | 2008 | Journal of Accounting Research2008，，3： | 1 |
| 9 | 评估复杂混合物(以柴油为例)对水体毒性的多面试验方法显示文摘柴油是一种对水体有毒害的复杂混合物,现以它为典型,用传统单一的毒性试验与多组分实验室微观分析相结合的方法评估其在水体中产生的毒害影响。我们用了14天的时间,研究了柴油的剂量对典型微观池塘内淡水生物群体的直接影响。多组分的实验室微观分析主要是测试柴油的剂量(1mg/l)对水、底泥(土壤与微生物群)。 | B.Thomas J hnson Vitaly I Romaentko 李思维 | 1991 | 黑龙江环境通报1991，0，1： | 0 |
| 10 | ecent Advances in the Science of Burst Wave Lithotripsy and Ultrasonic Propulsion显示文摘Objective.Retinal degeneration involving progressive deterioration and loss of function of photoreceptors is a major cause of permanent vision loss worldwide.Strategies to treat these incurable conditions incorporate retinal prostheses via electrically stimulating surviving retinal neurons with implanted devices in the eye,optogenetic therapy,and sonogenetic therapy.Existing challenges of these strategies include invasive manner,complex implantation surgeries,and risky gene therapy.Methods and Results.Here,we show that direct ultrasound stimulation on the retina can evoke neuron activities from the visual centers including the superior colliculus and the primary visual cortex(V1),in either normal-sighted or retinal degenerated blind rats in vivo.The neuron activities induced by the customized spherically focused 3.1 MHz ultrasound transducer have shown both good spatial resolution of 250μm and temporal resolution of 5 Hz in the rat visual centers.An additional customized 4.4 MHz helical transducer was further implemented to generate a static stimulation pattern of letter forms.Conclusion.Our findings demonstrate that ultrasound stimulation of the retina in vivo is a safe and effective approach with high spatiotemporal resolution,indicating a promising future of ultrasound stimulation as a novel and noninvasive visual prosthesis for translational applications in blind patients. | Xuejun Qian Gengxi Lu Biju B.Thomas Runze Li Xiaoyang Chen K.Kirk Shung Mark Humayun Qifa Zhou | 2022 | Biomedical Engineering Frontiers2022，3，1： | 0 |
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