| 1 | Innate lymphocytes-lineage,localizationandtimingof differentiation显示文摘Innate lymphocytes are a diverse population of cells that carry out specialized functions in steady-state homeostasis and during immune challenge.While circulating cytotoxic natural killer(NK)cells have been studied for decades,tissue-resident innate lymphoid cells(ILCs)have only been characterized and studied over the past few years.As ILCs have been largely viewed in the context of helper T-cell biology,models of ILC lineage and function have been founded within this perspective.Notably,tissue-resident innate lymphocytes with cytotoxic potential have been described in an array of tissues,yet whether they are derived from the NK or ILC lineage is only beginning to be elucidated.In this review,we aim to shed light on the identities of innate lymphocytes through the lenses of cell lineage,localization,and timing of differentiation. | Emily R.Kansler Ming O.Li | 2019 | Cellular & Molecular Immunology2019，16，7： | 2 |
| 3 | Metabolism along the life journey of T cells显示文摘T cells are one of few cell types in adult mammals that can proliferate extensively and differentiate diversely upon stimulation,which serves as an excellent example to dissect the metabolic basis of cell fate decisions.During the last decade,there has been an explosion of research into the metabolic control of T-cell responses.The roles of common metabolic pathways,including glycolysis,lipid metabolism,and mitochondrial oxidative phosphorylation,in T-cell responses have been well characterized,and their mechanisms of action are starting to emerge.In this review,we present several considerations for T-cell metabolism-focused research,while providing an overview of the metabolic control of T-cell fate decisions during their life journey.We try to synthesize principles that explain the causal relationship between cellular metabolism and T-cell fate decision.We also discuss key unresolved questions and challenges in targeting T-cell metabolism to treat disease. | Min Peng Ming O.Li | 2023 | Life Metabolism2023，2，1： | 0 |
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