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| 1 | 1544例乳腺浸润性导管癌临床特点和生存率的多因素分析显示文摘目的 分析乳腺浸润性导管癌的临床特点和预后因素。方法 1 544 例浸润性导管癌全部为九十年代新发病例。采用观察生存率、死亡危险比、Log rank检验和拟合多因素Cox比例风险回归模型等进行单因素和多因素分析,评估各种预后因素与乳腺癌的联系强度。结果 浸润性导管癌占女性乳腺癌的82.5%,腋淋巴结转移率44.2%。外上象限发病最多,占47.7%。肿块位中央区,腋淋巴结阳性率最高,占61.7%。Ⅰ、Ⅱ、Ⅲ、Ⅳ期病例分别占30.0%,59.4%,9.4%,1.2%;5年和10年生存率分别为94.9%,78.1%;48.1%,8.6%和87.2%,67.1%;31.2%,0.0%。单因素分析:发病年龄、肿块大小、腋淋巴结转移数、TNM分期、治疗方式与生存率有关;ER、PR、Her- 2/neu、手术类型与生存率无关。多因素分析显示:发病年龄、腋淋巴结转移数、治疗方式与生存率有关。结论 腋淋巴结状况是制定治疗方案和评估预后的最主要指标。50 岁以下发病的患者以及接受综合治疗的患者生存率较高。九十年代与八十年代相比,上海市区女性乳腺癌的诊治水平有了较大的提高。 | 高道利 王文婉 郁领娣 胡永伟 陆重志 David B.Thomas Roberta M.Ray Peggy Porter | 2005 | 肿瘤2005，25，2： | 8 |
| 2 | Risks of biliary tract cancer and occupational exposures among Shanghai women textile workers: A case‐cohort study显示文摘 | Chin‐KuoChang GeorgeAstrakianakis David B.Thomas Noah S.Seixas Janice E.Camp Roberta M.Ray DaoLi Gao Karen J.Wernli WenjinLi E. DawnFitzgibbons Thomas L.Vaughan HarveyCheckoway | 2006 | Am J Ind Med2006，，8： | 1 |
| 3 | Clinical Benefits of Antiviral Therapy in Patients with Recurrent Hepatitis C Following Liver Transplantation显示文摘 | M.Berenguer A.Palau V.Aguilera J.‐M.Rayón F. S.Juan M.Prieto | 2008 | American Journal of Transplantation2008，，3： | 1 |
| 4 | Anti-cancer effects of aloe-emodin:a systematic review显示文摘Background:Anthraquinones are a possible treatment option for oncological patients due to their anti-cancer properties.Cancer patients often exhaust a plethora of resources that ultimately fail to provide fully curative measures.Alternative treatments are subsequently sought in the hope of finding a therapeutic remedy.Potential regimens include aloe-emodin and its related derivatives.This review therefore summarizes the effects of aloe-emodin and other aloe components in light of their anti-proliferative and anti-carcinogenic properties.Methods:A systematic search was performed in PubMed for aloe-emodin and cancer in humans.Sixty abstracts of in vitro studies were selected and reviewed with subsequent screening of the full text.Thirty-eight articles were summarized.Results:Aloe-emodin possesses multiple anti-proliferative and anti-carcinogenic properties in a host of human cancer cell lines,with often multiple vital pathways affected by the same molecule.The most notable effects include inhibition of cell proliferation,migration,and invasion;cycle arrest;induction of cell death;mitochondrial membrane and redox perturbations;and modulation of immune signaling.The effects of aloe-emodin are not ubiquitous across all cell lines but depend on cell type.Conclusions:On the basis of this systematic review,the multiple consistent effects of aloe-emodin in human-derived cancer cell lines suggest that aloe-emodin is a potential anti-cancer agent that acts on cancer cells in a pleiotropic manner.Relevance for patients:Cancer patients often utilize alternative therapies as a result of suboptimal efficacy of conventional treatments.Aloe-emodin might become a therapeutic option for cancer patients if the basic research is confirmed in clinical trials. | Brian Sanders Anna M.Ray Sharon Goldberg Tyler Clark H.Reginald McDaniel Steven E.Atlas Ashar Farooqi Janet Konefal Lucas C.Lages Johanna Lopez Ammar Rasul Eduard Tiozzo Judi M.Woolger John E.Lewis | 2017 | Journal of Clinical & Translational Research2017，3，3： | 0 |
| 5 | The effect of exercise training on disease progression,fitness,quality of life,and mental health in people living with HIV on antiretroviral therapy:a systematic review显示文摘Background:Exercise has been associated with improvements in adverse physiological and psychological effects of long-term antiretroviral therapy(ART)in people living with HIV(PLWH).Aim:To summarizes the findings on the effects of aerobic or resistance training alone or combined aerobic and resistance exercise training(CARET)on disease progression,fitness,physical functioning,mental health,and quality of life(QOL)in PLWH receiving ART.A systematic search of articles was performed in several databases,and 20 articles that met inclusion criteria were summarized.Relevance for patients:Aerobic exercise was associated with improvements in aerobic capacity,QOL,and depressive symptoms,while resistance training improved strength.CARET was related to improved aerobic fitness,strength,physical functioning,QOL,and self-efficacy.At least one of the exercise interventions resulted in improvements in CD4+cell count and HIV RNA viral load.Moreover,another study showed that HIV-specific biomarkers remained unchanged in the exercise intervention group,while they significantly worsened in the non-exercise group.In general,in spite of their well-known benefits,exercise programs have not been extensively utilized or widely recognized as viable therapeutic treatment options for this patient population.Knowing the possible health benefits of increasing physical activity level is important to better recommend exercise programs.However,the prescription must be done carefully and on an individual basis.Additional studies investigating the efficiency and effectiveness of different exercise training regimens for PLWH are needed. | Johanna Lopez Erika Richardson Eduard Tiozzo Laura Lantigua Camilo Martinez George Abreut Troy Prendergast Steven E.Atlas Andrew R.Pangilinan Serena M.Ferris Ana H.Martinez Janet Konefal Judi Woolger Anna M.Ray Herbert G.Sim?es Carmen S.G.Campbell John E.Lewis | 2015 | Journal of Clinical & Translational Research2015，1，3： | 0 |
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