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| 1 | Highly Fluorescent Dye-Doped Silica Nanoparticles Increase Flow Cytometry Sensitivity for Cancer Cell Monitoring显示文摘Early and accurate diagnosis and treatment of cancer depend on rapid,sensitive,and selective detection of tumor cells.Current diagnosis of cancers,especially leukemia,relies on histology and fl ow cytometry using single dye-labeled antibodies.However,this combination may not lead to high signal output,which can hinder detection,especially when the probes have relatively weak affi nities or when the receptor is expressed in a low concentration on the target cell surface.To solve these problems,we have developed a novel method for sensitive and rapid detection of cancer cells using dye-doped silica nanoparticles(NPs)which increases detection sensitivity in fl ow cytometry analyses between 10-and 100-fold compared to standard methods.Our NPs are~60 nm in size and can encapsulate thousands of individual dye molecules within their matrix.We have extensively investigated surface modifi cation strategies in order to make the NPs suitable for selective detection of cancer cells using fl ow cytometry.The NPs are functionalized with polyethylene glycol(PEG)to prevent nonspecifi c interactions and with neutravidin to allow universal binding with biotinylated molecules.By virtue of their reliable and selective detection of target cancer cells,these NPs have demonstrated their promising usefulness in conventional fl ow cytometry.Moreover,they have shown low background signal,high signal enhancement,and effi cient functionalization,either with antibody-or aptamer-targeting moieties. | M.-Carmen Estévez Meghan B.OʼDonoghue Xiaolan Chen Weihong Tan | 2009 | Nano Research2009，2，6： | 3 |
| 2 | The Question of Participation:Toward Authentic Public Participation in Public Adminis-tration显示文摘 | King C.S Feltey K.M Susel B.O | | 0，，04： | 1 |
| 3 | Analysis of velocity profile measurements from wind-tunnel experiments with saltation显示文摘 | B.O Bauer C.A Houser W.G Nickling | 2003 | Geomorphology2003，，1： | 1 |
| 4 | MD&A; Quality as Measured by the SEC and Analysts’ Earnings Forecasts*显示文摘 | ORIE E.BARRON CHARLES O.KILE TERRENCE B.O’KEEFE | 2010 | Contemporary Accounting Research2010，，1： | 1 |
| 5 | 查看详情显示文摘 | C.Heise D.Figueroa B.O'Dowd | | 0，，： | 1 |
| 6 | Long-Term Storm water Quantity and Quality Performance of Permeable Pavement Systems显示文摘 | BRATTEBO B.O BOOTH D.B | | 0，，： | 1 |
| 7 | Use of biochar as bulking agent for the composting of poultry manure:Effect on organic matter degradation and humification显示文摘 | Dias B.O Silva C.A Higashikawa F.S Roig A SánchezMonedero M.A | | 0，，： | 1 |
| 8 | Stoichiometric interpretation of Escherichia coli glucose catabolism under various oxygenation rates显示文摘 | Varma A Boesch B.W Palsson B.O | | 0，，： | 1 |
| 9 | Prognostic factors in patients hospitalized with acute heart failure syndrome显示文摘Each year, there are over one million hospitalizations for acute heart failure syndrome (AHFS) in the United States alone,with a similar number in Western Europe. These patients have very high short-term (2-6 months) mortality and readmission rates, while the healthcare system incurs substantial costs. Until recently, the clinical characteristics, management patterns, and outcomes of these patients have been poorly understood and, in consequence, risk stratification for these patients has not been well defined. Several risk prediction models that can accurately identify high-risk patients have been developed in the last year using data from clinical trials, large registries or administrative databases. Use of multi-variable risk models at the time of hospital admission or discharge offers better risk stratification and should be encouraged, as it allows for appropriate allocation of existing resources and development of clinical trials testing new treatment strategies for patients admitted with AHFS. The emerging observation that the prognosis for the ensuing three to six months may be obtained at presentation for AHFS has major implications for development of future therapies. | Liviu Klein John B.O’Connell | 2006 | Journal of Geriatric Cardiology2006，3，4： | 1 |
| 10 | Factors predictive of 5‐year survival after transarterial chemoembolization for inoperable hepatocellular carcinoma显示文摘 | C. B.O’Suilleabhain R. T. P.Poon J. L.Yong G. C.Ooi W. K.Tso S. T.Fan | 2003 | Br J Surg2003，，3： | 1 |
| 11 | Relation of starch composition protein content,and gelatinization temperature to cooking and eating qualities of milled rice显示文摘 | Juliano B.O Onate LU Dd Mundo A.M | | 0，，： | 1 |
| 12 | Hardness of cooked milled rice by instrumental and sensory methods显示文摘 | Perez C.M Juliano B.O | | 0，，： | 1 |
| 13 | A logical approach to formalizing organizational ecology显示文摘 | Peli G Bruggeman J Masuch M Nuallain B.O | | 0，，： | 1 |
| 14 | Factors influencing soybean utilization in the household consumer market显示文摘 | E.A Dionco-Adetayo O.F Olaniyan B.O Ogunba | 2001 | Technovation2001，，2： | 1 |
| 15 | 查看详情显示文摘 | Lee J.H Ko K.H Park B.O | | 0，，： | 1 |
| 16 | MD&A Quality as Measured by the SEC and Analysts’ Earnings Forecasts*显示文摘 | ORIE E.BARRON CHARLES O.KILE TERRENCE B.O’KEEFE | 2010 | Contemporary Accounting Research2010，，1： | 1 |
| 17 | A quantum chemical study of the quintuple bond between two chromium centers in[PhCrCrPh]:trans-bent versus linear geometry显示文摘 | Brynda M Gagliardi L Wimark P.O Power P.P. Roos B.O | | 0，，： | 1 |
| 18 | Rationale and Design of the Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation (THE BALANCE) Study显示文摘 | William T.Abraham Juan M.Aranda John P.Boehmer UriElkayam Edward M.Gilbert Stephen S.Gottlieb GerdHasenfuβ MarrickKukin Brian D.Lowes John B.O'Connell LuigiTavazzi Arthur M.Feldman BarryTicho CesareOrlandi | 2010 | Clinical and Translational Science2010，，5： | 1 |
| 19 | Secure data networks for electrical distribution applications显示文摘Smart Grids are characterized by the application of information communication technology(ICT)to solve electrical energy challenges.Electric power networks span large geographical areas,thus a necessary component of many Smart Grid applications is a wide area network(WAN).For the Smart Grid to be successful,utilities must be confident that the communications infrastructure is secure.This paper describes how a WAN can be deployed using WiMAX radio technology to provide high bandwidth communications to areas not commonly served by utility communications,such as generators embedded in the distribution network.A planning exercise is described,using Northern Ireland as a case study.The suitability of the technology for real-time applications is assessed using experimentally obtained latency data. | David M.LAVERTY John B.O’RAW Kang LI D.John MORROW | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 1 |
| 20 | Parent involvement and views of school success:The role of parents' Latino and white American cultural orientations显示文摘 | Ryan C.S Casas J.F Kelly-Vance L Ryalls B.O Nero C | | 0，，： | 1 |
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