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| 1 | Urban-Rural Comparison of HBV and HCV Infection Prevalence in Eastern China显示文摘The present study was initiated to make an urban rural comparison of the prevalence of cases positive to hepatitis B and C virus (HBV and HCV, respectively) infection markers in densely populated eastern half of China. For this purpose, 10 survey sites were selected, i.e., six sites in urban areas (the city group; Beijing, Shanghai and four provincial capitals) and four sites in rural areas (the village group ; one village each in Jilin and Shandong Provinces, and two villages in Shaanxi Province). About 50 adult women per site volunteered to participate, from whom 494 valid blood samples were collected. Positivities to HBsAg (HBsAg +), anti HBs (anti HBs +) and anti HBc (anti HBc +) were examined by RIA methods, and that to anti HCV (anti HCV +) by either EIA or RIA. Those positive to any one of the three HBV infection markers were taken as HBV infection positive (HBV +). The prevalence of HBsAg +, HBV + and anti HBc + was 8%, 70% and 2.7% in the city group, and 8%, 65% and 2.0% in the village group, and no significant difference was found between the two groups. The overall prevalence was 8% for HBsAg +, 68% for HBV +, and 2.4% for anti HCV +. The results were discussed in reference to some 20 papers each on HBV + and anti HCV + prevalence in China published since 1991. The reviewing of these papers confirmed that the prevalence of HBV was high (i.e., in excess of 50%), whereas the prevalence of anti HCV was low (well below 5%), and that no substantial difference was found between the rural and urban populations. | QU JIANG-BIN ZHANG ZUO-WEN SHINICHIRO SHIMBO TAKAO WATANABE HARUO NAKATSUKA NAOKO MATSUDA-INOGUCHI KAE HIGASHIKAWA MASAYUKI IKEDA | 2000 | Biomedical and Environmental Sciences2000，13，4： | 3 |
| 2 | Angiotensin receptor blocker neprilysin inhibitors显示文摘Heart failure(HF)is a clinical syndrome that results from a structural or functional cardiac disorder that reduces the ability of the ventricle of the heart to fill with,or eject,blood.It is a multifaceted clinical condition that affects up to 2%of the population in the developed world,and is linked to significant morbidity and mortality;it is therefore considered a major concern for public health.Regarding the mechanism of HF,three neurohumoral factors-the reninangiotensin-aldosterone system,the sympathetic nervous system,and natriuretic peptides—are related to the pathology of chronic HF(CHF),and the targets of treatment.Angiotensin receptor blocker and neprilysin inhibitor(angiotensinreceptor neprilysin inhibitor),namely sacubitril/valsartan(SAC/VAL),has been introduced as a treatment for CHF.SAC/VAL is an efficacious,safe,and costeffective therapy that improves quality of life and longevity in patients with HF with reduced ejection fraction(HFrEF),and reduces hospital admissions.An inhospital initiation strategy offers a potential new avenue to improve the clinical uptake of SAC/VAL.In the last five years,SAC/VAL has been established as a cornerstone component of comprehensive disease-modifying medical therapy in the management of chronic HFrEF.On the other hand,further work,with carefully designed and controlled preclinical studies,is necessary for understanding the molecular mechanisms,effects,and confirmation of issues such as long-term safety in both human and animal models. | Daisuke Usuda Toshihiro Higashikawa Yuta Hotchi Kenki Usami Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Toshihiko Yoshizawa Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita | 2021 | World Journal of Cardiology2021，13，8： | 2 |
| 3 | Intracranial malignant solitary fibrous tumor metastasized to the chest wall:A case report and review of literature显示文摘BACKGROUND Solitary fibrous tumor(SFT)is a rare fibroblastic mesenchymal neoplasm that affects spindle cell soft tissues with broad-spectrum biological behavior;it is predominantly benign,and rarely metastasizes.SFT occurs mainly in the tissue structure of the serosa in the pleura and the thorax,and can be found throughout the body,though extra-thoracic localization,including the cephalic region,is uncommon.We reported the first case of intracranial malignant SFT metastasized to the chest wall.CASE SUMMARY An 81-year-old Japanese man was referred to our hospital due to progressive gait disturbance and appetite loss.His medical history included partial resection due to brain tumor,four times,and 50-Gray radiation therapy at another hospital,starting when he was 74 years old.An unenhanced head computed tomography(CT)scan revealed an 8 cm×5.1 cm×6.5 cm mixed-density mass at the left frontal lobe,accompanying a midline shift,and an unenhanced chest-abdomen CT scan revealed a 6 cm×4.1 cm×6.5 cm low-density mass in the left chest wall.A CT-guided percutaneous lung biopsy was performed,and the pathological findings were SFT corresponding to brain tumor.Finally,the correct diagnosis of his brain tumor in history of past illness revealed to be SFT,and the unremovable tumor,namely present brain lesions enlarged and metastasized to the chest wall.We established a definitive diagnosis of intracranial malignant SFT metastasized to the chest wall.We notified him and his family of the disease,and offered palliative care.He passed away on the 29 th hospital day.CONCLUSION This case suggests the need for careful,detailed examination,and careful followup when encountering patients presenting with a mass. | Daisuke Usuda Shinya Yamada Toshihide Izumida Ryusho Sangen Toshihiro Higashikawa Ken Nakagawa Masaharu Iguchi Yuji Kasamaki | 2020 | World Journal of Clinical Cases2020，8，20： | 2 |
| 4 | Distinct structural re- quirements for binding of the integrins alphavbeta6, alphavbeta3, al- phavbeta5,alphaSbetal and alpha9betal to osteopontin 显示文摘 | Yokosaki Y Tanaka K Higashikawa F | 2005 | Matrix Biol2005，24，6： | 1 |
| 5 | Gene ex- pression profiling to identify genes associated with high -invasiveness in human squamous cell carcinoma with epithelial - to - mesenchymal transition 显示文摘 | Higashikawa K Yoneda S Taki M | 2008 | Cancer Lett2008，264，： | 1 |
| 6 | Evaluation of CD44 transcription variants in human digestive tract carcinomas and normal tissues显示文摘 | Higashikawa K Yokozaki H Ue T | 2006 | Int J Cancer2006，66，： | 1 |
| 7 | Snail-induced down- regulation of DehaNp63alpha acquires invasive phenotype of human squamous cell carcinoma显示文摘 | Higashikawa K Yoneda S Tobiume K | 2007 | Cancer Res2007，67，19： | 1 |
| 8 | Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors显示文摘 | Shigeishi H Mizuta K Higashikawa K | 2005 | Oral Oncol2005，41，7： | 1 |
| 9 | Conceptual Design of HTS Coil for SMES Using YBCO Coated Conductor 显示文摘 | Higashikawa K | 2007 | IEEE Transactions on Applied Superconductivity2007，17，2： | 1 |
| 10 | Delta Np63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma显示文摘 | Higashikawa K Yoneda S Tobiume K | 2009 | Int J Cancer2009，124，12： | 1 |
| 11 | Non-occupational lead and cadmium exposure of adult women in Bangkok, Thailand显示文摘 | Zuo-Wen Zhang Shinichiro Shimbo Takao Watanabe Songsak Srianujata Orapin Banjong Chureeporn Chitchumroonchokchai Haruo Nakatsuka Naoko Matsuda-Inoguchi Kae Higashikawa Masayuki Ikeda | 1999 | Science of the Total Environment1999，，1： | 1 |
| 12 | Non-occupational exposure of adult women in Manila, the Philippines, to lead and cadmium显示文摘 | Z.-W Zhang R.D Subida M.G Agetano H Nakatsuka N Inoguchi T Watanabe S Shimbo K Higashikawa M Ikeda | 1998 | Science of the Total Environment1998，，1： | 1 |
| 13 | Snail-induced down-regulation of DeltaNp63 alpha acquires invasive phenotype of human squamous cell carcinoma显示文摘 | Higashikawa K Yoneda S Tobiume K | 2007 | Cancer Res2007，67，19： | 1 |
| 14 | Use of bioehar as bulking a- gent for the composting of poultry manure:Effect on organic matter degradation and humification显示文摘 | Dias B O Silva C A Higashikawa F S | 2010 | Bioresource Teehnalogy2010，101，4： | 1 |
| 15 | The obesity and fatty liver are reduced by plant-derived Pediococcus pentosaceus LP28 in high fat diet-' induced obese mice显示文摘 | ZHAO X HIGASHIKAWA F NODA M | 2012 | PLoS 0ne2012，7，30： | 1 |
| 16 | Evaluation of CD44 transcrip- tion variants in human digestive tract carcinomas and normal tissue 显示文摘 | Higashikawa K Yokozaki H Ue T | 1996 | Int J Cancer1996，66，1： | 1 |
| 17 | Correla-tion of CENPF gene expression with tumor-proliferating activityin human salivary gland tomors显示文摘 | SHIGEISHI H MIZUTA K HIGASHIKAWA K | 2005 | Oral Oncol2005，41，7： | 1 |
| 18 | Mechanisms underlying catabolic and anabolic functions of parathyroid hormone on bone by combination of culture systems of mouse ceils 显示文摘 | Shinoda Y Kawaguchi H Higashikawa A | 2010 | J Cell Biochem2010，109，4： | 1 |
| 19 | Use of biochar as bulking agent for the composting of poultry manure:Effect on organic matter degradation and humification显示文摘 | Dias B O Silva C A Higashikawa F S | 2010 | Bioresource Technology2010，101，4： | 1 |
| 20 | Identification of the Core Element Responsive to Runt - Related Transcription Factor 2 in the Promoter of Human Type Ⅹ Collagen Gen 显示文摘 | Higashikawa A Saito T Ikeda T | 2009 | Arthritis and Rheumatism2009，60，： | 1 |
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