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| 1 | Pancreatic intraductal papillary mucinous neoplasms:Current diagnosis and management显示文摘Intraductal papillary mucinous neoplasms(IPMNs)represent approximately 1%of all pancreatic neoplasms and 25%of cystic neoplasms.They are divided into three types:main duct-IPMN(MD-IPPMN),branch duct-IPMN(BD-IPMN),and mixed type-IPMN.In this review,diagnostics,including clinical presentation and radiological investigations,were described.Magnetic resonance imaging is the most useful for most IPMNs.Management depends on the type and radiological features of IPMNs.Surgery is recommended for MD-IPMN.For BD-IPMN,management involves surgery or surveillance depending on the tumor size,cyst growth rate,solid components,main duct dilatation,high-grade dysplasia in cytology,the presence of symptoms(jaundice,new-onset diabetes,pancreatitis),and CA 19.9 serum level.The patient’s age and comorbidities should also be taken into consideration.Currently,there are different guidelines regarding the diagnosis and management of IPMNs.In this review,the following guidelines were presented:Sendai International Association of Pancreatology guidelines(2006),American Gastroenterological Association guidelines,revised international consensus Fukuoka guidelines(2012),revised international consensus Fukuoka guidelines(2017),and European evidence-based guidelines according to the European Study Group on Cystic Tumours of the Pancreas(2018).The Verona Evidence-Based Meeting 2020 was also presented and discussed. | Beata Jabłońska PawełSzmigiel Sławomir Mrowiec | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 3 |
| 2 | Impact of sodium glucose cotransporter-2 inhibitors on liver steatosis/fibrosis/inflammation and redox balance in non-alcoholic fatty liver disease显示文摘BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT2-I)are the most recently approved drugs for type 2 diabetes(T2D).Recent clinical trials of these compounds reported beneficial cardiovascular(CV)and renal outcomes.A major cause of vascular dysfunction and CV disease in diabetes is hyperglycemia associated with inflammation and oxidative stress.Pre-clinical studies demonstrated that SGLT2-I reduce glucotoxicity and promote anti-inflammatory effects by lowering oxidative stress.AIM To investigate the effects of SGLT2-I on markers of oxidative stress,inflammation,liver steatosis,and fibrosis in patients of T2D with non-alcoholic fatty liver disease(NAFLD).METHODS We referred fifty-two consecutive outpatients treated with metformin monotherapy and exhibiting poor glycemic control to our centre.We introduced the outpatients to an SGLT2-I(dapagliflozin,empagliflozin,or canagliflozin;n=26)or a different hypoglycemic drug[other glucose-lowering drugs(OTHER),n=26].We evaluated circulating interleukins and serum hydroxynonenal(HNE)-or malondialdehyde(MDA)-protein adducts,fatty liver index(FLI),NAFLD fibrosis score,aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST-to-platelet-ratio index(APRI),and fibrosis-4 on the day before(T0)and following treatment for six months(T1).We also performed transient elastography at T0 and T1.RESULTS Add-on therapy resulted in improved glycemic control and reduced fasting blood glucose in both groups.Of note,following treatment for six months,a reduction of FLI and APRI,as well as of the FibroScan result,was reported in patients treated with SGLT2-I,but not in the OTHER group;furthermore,in the SGLT2-I group,we reported lower circulating levels of interleukin(IL)-1β,IL-6,tumor necrosis factor,vascular endothelial growth factor,and monocyte chemoattractant protein-1,and higher levels of IL-4 and IL-10.We did not observe any modification in circulating interleukins in the OTHER group.Finally,serum HNE-and MDA-protein adducts decreased significantly in SGLT2-I rather than OTHER patients and correlated with liver steatosis and fibrosis scores.CONCLUSION The present data indicate that treatment with SGLT2-I in patients with T2D and NAFLD is associated with improvement of liver steatosis and fibrosis markers and circulating pro-inflammatory and redox status,more than optimizing glycemic control. | Francesco Bellanti Aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Palok Aich Shivaram P Singh Gaetano Serviddio Gianluigi Vendemiale | 2022 | World Journal of Gastroenterology2022，28，26： | 3 |
| 3 | Gene expression and activity of antioxidant enzymes in the blood cells of workers who were occupationally exposed to lead显示文摘 | Aleksandra Kasperczyk Grzegorz Machnik Micha? Dobrakowski Daniel Sypniewski Ewa Birkner S?awomir Kasperczyk | 2012 | Toxicology (-)2012，，1： | 1 |
| 4 | Selenium affects physiological parameters and phytochelatins accumulation in cucumber ( Cucumis sativus L.) plants grown under cadmium exposure显示文摘 | Barbara Hawrylak-Nowak S?awomir Dresler Ma?gorzata Wójcik | 2014 | Scientia Horticulturae2014，，： | 1 |
| 5 | Ischaemia modified albumin in patients with acute coronary syndrome and negative cardiac troponin I显示文摘 | Gra?yna Sygitowicz Jadwiga Janas S?awomir Bia?ek Jerzy Pr?gowski ?ukasz Pera Dariusz Sitkiewicz | 2013 | Scandinavian Journal of Clinical & Laboratory Investigation2013，，： | 1 |
| 6 | Gut microbiota neurotransmitters:influence on risk and outcome of ischemic stroke显示文摘Ischemic stroke:Stroke is the second and third cause of death and disability,respectively,with an annual rate of 24.9 million cases worldwide(Chidambaram et al.,2022).Stroke is defined as the lack of blood supply to a specific area of the brain,accounti ng for 85%of all cases (Chidambaram et al.,2022). | Ryszard Pluta Sławomir Januszewski | 2023 | Neural Regeneration Research2023，18，8： | 1 |
| 7 | Separation of betalains from berries of Phytolacca americana by ion-pair high-speed counter-current chromatography显示文摘 | Gerold Jerz Tanja Skotzki Kathrin Fiege Peter Winterhalter S?awomir Wybraniec | 2008 | Journal of Chromatography A2008，，1： | 1 |
| 8 | Numerical prediction of the hardened zone in laser treatment of carbon steel显示文摘 | Adam Bokota S awomir Iskierka | | 0，，02： | 1 |
| 9 | Influence of Fluoride on Rat Kidney Antioxidant System: Effects of Methionine and Vitamin E显示文摘 | Iwona B?aszczyk Ewa Grucka-Mamczar S?awomir Kasperczyk Ewa Birkner | 2008 | Biological Trace Element Research2008，，1： | 1 |
| 10 | Fossil fuel prices, exchange rate, and stock market: A dynamic causality analysis on the European market显示文摘 | S?awomir ?miech Monika Papie? | 2013 | Economics Letters2013，，1： | 1 |
| 11 | Normalisation of elevated ST segment predicts return of left ventricular systolic function and improved outcome in patients with acute myocardial infarction,treated with primary coronary angioplasty显示文摘 | Anna TK dzimierz MS Awomir D | | 0，，06： | 1 |
| 12 | Localized gastric diffuse large B-cell lymphoma and Hodgkin’s lymphoma as secondary neoplasms in two patients with chronic lymphocytic leukemia显示文摘 | Monika Prochorec-Sobieszek Miros?aw Majewski Anna Sikorska Kinga Kos S?awomir Huszcza Renata K. Maryniak | 2006 | Leukemia & Lymphoma2006，，10： | 1 |
| 13 | Dynamics of three-dimensional temperature field in electrical system of floor heating显示文摘 | Jerzy Golbiowski S?awomir Kwiec kowski | 2002 | International Journal of Heat and Mass Transfer2002，45，： | 1 |
| 14 | Fast Implementation of Median Filter显示文摘 | Awomir Jezewski Krzysztof Strzeeha | 2003 | CADSM'' 2003 Lviv - Siasko Ukraine2003，2003，： | 1 |
| 15 | Barium-promoted Ru/carbon catalyst for ammonia synthesis: State of the system when operating显示文摘 | El?bieta Truszkiewicz Wioletta Raróg-Pilecka Krzysztof Schmidt-Sza?owski S?awomir Jodzis Ewa Wilczkowska Dariusz ?omot Zbigniew Kaszkur Zbigniew Karpiński Zbigniew Kowalczyk | 2009 | Journal of Catalysis2009，，2： | 1 |
| 16 | The effect of IL-2, IL-12 and ILl5 on the function of natural killer cells in children suffering from type 1 diabetes mellitus显示文摘 | Awomir C Ewa P Marcin M | 2013 | Pediatric Endocrinology Diabetes & Metabolism2013，19，： | 1 |
| 17 | Normalisation of elevated ST segment predicts return of left ventricular systolic function and improved outcome in patients with aeute myocardial infarction, treated with primary coronary angioplasty 显示文摘 | Anna T K Dzimierz M S Awomir D | 2004 | Kardiol Pol2004，60，6： | 1 |
| 18 | Impact of senescence on the transdifferentiation process of human hepatic progenitor-like cells显示文摘BACKGROUND Senescence is characterized by a decline in hepatocyte function,with impairment of metabolism and regenerative capacity.Several models that duplicate liver functions in vitro are essential tools for studying drug metabolism,liver diseases,and organ regeneration.The human HepaRG cell line represents an effective model for the study of liver metabolism and hepatic progenitors.However,the impact of senescence on HepaRG cells is not yet known.AIM To characterize the effects of senescence on the transdifferentiation capacity and mitochondrial metabolism of human HepaRG cells.METHODS We compared the transdifferentiation capacity of cells over 10(passage 10[P10])vs P20.Aging was evaluated by senescence-associated(SA)beta-galactosidase activity and the comet assay.HepaRG transdifferentiation was analyzed by confocal microscopy and flow cytometry(expression of cluster of differentiation 49a[CD49a],CD49f,CD184,epithelial cell adhesion molecule[EpCAM],and cytokeratin 19[CK19]),quantitative PCR analysis(expression of albumin,cytochrome P4503A4[CYP3A4],γ-glutamyl transpeptidase[γ-GT],and carcinoembryonic antigen[CEA]),and functional analyses(albumin secretion,CYP3A4,andγ-GT).Mitochondrial respiration and the ATP and nicotinamide adenine dinucleotide(NAD^(+))/NAD with hydrogen(NADH)content were also measured.RESULTS SAβ-galactosidase staining was higher in P20 than P10 HepaRG cells;in parallel,the comet assay showed consistent DNA damage in P20 HepaRG cells.With respect to P10,P20 HepaRG cells exhibited a reduction of CD49a,CD49f,CD184,EpCAM,and CK19 after the induction of transdifferentiation.Furthermore,lower gene expression of albumin,CYP3A4,andγ-GT,as well as reduced albumin secretion capacity,CYP3A4,andγ-GT activity were reported in transdifferentiated P20 compared to P10 cells.By contrast,the gene expression level of CEA was not reduced by transdifferentiation in P20 cells.Of note,both cellular and mitochondrial oxygen consumption was lower in P20 than in P10 transdifferentiated cells.Finally,both ATP and NAD^(+)/NADH were depleted in P20 cells with respect to P10 cells.CONCLUSION SA mitochondrial dysfunction may limit the transdifferentiation potential of HepaRG cells,with consequent impairment of metabolic and regenerative properties,which may alter applications in basic studies. | Francesco Bellanti Giorgia di Bello Rosanna Tamborra Marco Amatruda Aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Gaetano Serviddio Gianluigi Vendemiale | 2021 | World Journal of Stem Cells2021，13，10： | 1 |
| 19 | Percutaneous edwards SAPIEN<sup>?</sup> valve implantation for significant pulmonary regurgitation after previous surgical repair with a right ventricular outflow patch显示文摘 | Marcin Demkow Witold Ru?y??o El?bieta Katarzyna Biernacka ?ukasz Kalińczuk Mateusz ?piewak Miros?aw Kowalski Ewa Sitkowska Mariusz Ku?mierczyk Jacek Ró?anski S?awomir Bana? Zbigniew Chmielak Piotr Hoffman | 2014 | Cathet Cardiovasc Intervent2014，，3： | 1 |
| 20 | Ultrasonographic evaluation of knee joints in patients with Lyme disease显示文摘 | Piotr Czupryna Anna Moniuszko Anna Czeczuga S?awomir Pancewicz Joanna Zajkowska | | International Journal of Infectious Diseases0，，： | 1 |
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