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| 1 | Impact of sodium glucose cotransporter-2 inhibitors on liver steatosis/fibrosis/inflammation and redox balance in non-alcoholic fatty liver disease显示文摘BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT2-I)are the most recently approved drugs for type 2 diabetes(T2D).Recent clinical trials of these compounds reported beneficial cardiovascular(CV)and renal outcomes.A major cause of vascular dysfunction and CV disease in diabetes is hyperglycemia associated with inflammation and oxidative stress.Pre-clinical studies demonstrated that SGLT2-I reduce glucotoxicity and promote anti-inflammatory effects by lowering oxidative stress.AIM To investigate the effects of SGLT2-I on markers of oxidative stress,inflammation,liver steatosis,and fibrosis in patients of T2D with non-alcoholic fatty liver disease(NAFLD).METHODS We referred fifty-two consecutive outpatients treated with metformin monotherapy and exhibiting poor glycemic control to our centre.We introduced the outpatients to an SGLT2-I(dapagliflozin,empagliflozin,or canagliflozin;n=26)or a different hypoglycemic drug[other glucose-lowering drugs(OTHER),n=26].We evaluated circulating interleukins and serum hydroxynonenal(HNE)-or malondialdehyde(MDA)-protein adducts,fatty liver index(FLI),NAFLD fibrosis score,aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST-to-platelet-ratio index(APRI),and fibrosis-4 on the day before(T0)and following treatment for six months(T1).We also performed transient elastography at T0 and T1.RESULTS Add-on therapy resulted in improved glycemic control and reduced fasting blood glucose in both groups.Of note,following treatment for six months,a reduction of FLI and APRI,as well as of the FibroScan result,was reported in patients treated with SGLT2-I,but not in the OTHER group;furthermore,in the SGLT2-I group,we reported lower circulating levels of interleukin(IL)-1β,IL-6,tumor necrosis factor,vascular endothelial growth factor,and monocyte chemoattractant protein-1,and higher levels of IL-4 and IL-10.We did not observe any modification in circulating interleukins in the OTHER group.Finally,serum HNE-and MDA-protein adducts decreased significantly in SGLT2-I rather than OTHER patients and correlated with liver steatosis and fibrosis scores.CONCLUSION The present data indicate that treatment with SGLT2-I in patients with T2D and NAFLD is associated with improvement of liver steatosis and fibrosis markers and circulating pro-inflammatory and redox status,more than optimizing glycemic control. | Francesco Bellanti Aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Palok Aich Shivaram P Singh Gaetano Serviddio Gianluigi Vendemiale | 2022 | World Journal of Gastroenterology2022，28，26： | 3 |
| 2 | Gene expression and activity of antioxidant enzymes in the blood cells of workers who were occupationally exposed to lead显示文摘 | Aleksandra Kasperczyk Grzegorz Machnik Micha? Dobrakowski Daniel Sypniewski Ewa Birkner S?awomir Kasperczyk | 2012 | Toxicology (-)2012，，1： | 1 |
| 3 | Degradation of copolymers obtained by ring-opening polymerization of glycolide and 3-caprolactone:A high resolution NMR and ESI-MS study显示文摘 | Kasperczyk J Li S Jaworska J | 2008 | Polym Degrad Stab2008，93，： | 1 |
| 4 | Activity of lutathione peroxidase, glutathione reductase, and lipid peroxidation in erythrocytes in workers exposed to lead 显示文摘 | Kasperczyk S Kasperczyk A Ostalowska A | 2004 | Biol Trace Elem Res2004，102，13： | 1 |
| 5 | Influence of methionine on toxicity of fluoride in the liver of rats显示文摘 | Blaszczyk I Birkner E Kasperczyk S | 2011 | Biol Trace Elem Res2011，139，3： | 1 |
| 6 | Microstructural analysis of poly by 1H and 13C-NMR spectroscopy显示文摘 | Kasperczyk J | 1996 | Polymer1996，37，2： | 1 |
| 7 | Effect of garlic supplementation on erythrocytes antioxidant parameters,lipid peroxidation,and atherosclerotic plaque formation process in oxi-dized oil-fed rabbits显示文摘 | ZALEJSKA-FIOLKA J KASPERCZYK A KASPERCZYK S | 2007 | Biological Trace Element Research2007，120，13： | 1 |
| 8 | 显示文摘 | Dobrzynski P Kasperczyk J Jelonek K | 2006 | J Biomed Mater Res2006，79，： | 1 |
| 9 | Influence of methionine on toxicity of fluoride in the liver of rats显示文摘 | Blaszeyk I Birkner E Kasperczyk S | 2011 | Biol Trace Elem Res2011，139，3： | 1 |
| 10 | The application of microspheres from the copolymers of lactide and ε-cap- rolactone to the controlled release of steroids 显示文摘 | BUNTNER B NOWAK M KASPERCZYK J | 1998 | J Control Release1998，56，13： | 1 |
| 11 | 显示文摘 | Kasperczyk J Bero M | 1993 | Makromol Chem1993，194，： | 1 |
| 12 | 显示文摘 | Bero M Kasperczyk J | 1996 | Makromol Chem1996，197，： | 1 |
| 13 | 显示文摘 | Kasperczyk J | 2001 | Macromol Symp2001，1751，： | 1 |
| 14 | Stereoselective polymerization of racemic DL-lactide in the presence of butyllithium and butylmagnesium:Structural investigations of the polymers显示文摘 | Kasperczyk J Bero M | 2000 | Polymer2000，41，： | 1 |
| 15 | Influence of fluoride on rat kidney antioxidant system:effects of methionine and vitamin E显示文摘 | Blaszczyk I Grucka-Mamczar E Kasperczyk S | 2008 | Biol Trace Elem Res2008，121，1： | 1 |
| 16 | Evaluation of Cam- type femoroacetabular impingement by ultrasound显示文摘 | Lerch S Kasperczyk A Warnecke J | 2013 | Int Orthop2013，37，5： | 1 |
| 17 | Betulinic acid as new activator of NF-KB:molec- ular mechanisms and implications for cancer therapy显示文摘 | KASPERCZYK H LAFERLA-BRUHL K WESTHOFF M A | 2005 | Oncogene2005，24，46： | 1 |
| 18 | Assessment of semen function and lipid peroxidation among lead exposed men 显示文摘 | KASPERCZYK A KASPERCZYK S HORAK S | 2008 | Toxicology and Applied Pharmacology2008，228，3： | 1 |
| 19 | Application of calcium acetylacetonate to the polymerization of glycolide and copolymerization of glycolide with ε-caprolactone and L-lactide显示文摘 | Dobrzynski P Kasperczyk J Bero M | 1999 | Macromolecules1999，32，： | 1 |
| 20 | Sensitization of euroblastoma cells for TRAIL-induced apoptosis by NF-kap- paB inhibition显示文摘 | AMMANN JU HAAG C KASPERCZYK H | 2009 | Int J Cancer2009，124，6： | 1 |
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