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| 1 | Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation显示文摘AIM:To investigate large tumor suppressor 1 (LATS1 ) expression, promoter hypermethylation, and microsatellite instability in colorectal cancer (CRC).METHODS:RNA was isolated from tumor tissue of 142 CRC patients and 40 colon mucosal biopsies of healthy controls. After reverse transcription, quantitative polymerase chain reaction (PCR) was performed, and LATS1 expression was normalized to expression of the ACTB and RPL32 housekeeping genes. To analyze hypermethylation, genomic DNA was isolated from 44 tumor CRC biopsies, and methylation-specific PCR was performed. Microsatellite instability (MSI) status was checked with PCR using BAT26, BAT25, and BAT40 markers in the genomic DNA of 84 CRC patients, followed by denaturing gel electrophoresis. RESULTS:Decreased LATS1 expression was found in 127/142 (89.4%) CRC cases with the average ratio of the LATS1 level 10.33 ± 32.64 in CRC patients vs 32.85 ± 33.56 in healthy controls. The lowest expression was found in Dukes' B stage tumors and G1 (welldifferentiated) cells. Hypermethylation of the LATS1 promoter was present in 25/44 (57%) CRC cases analyzed. LATS1 promoter hypermethylation was strongly associated with decreased gene expression; methylated cases showed 162× lower expression of LATS1 than unmethylated cases. Although high-grade MSI (mutation in all three markers) was found in 14/84 (17%) cases and low-grade MSI (mutation in 1-2 markers) was found in 30/84 (36%) cases, we found no association with LATS1 expression. CONCLUSION:Decreased expression of LATS1 in CRC was associated with promoter hypermethylation, but not MSI status. Such reduced expression may promote progression of CRC. | Piotr M Wierzbicki Krystian Adrych Dorota Kartanowicz Marcin Stanislawowski Anna Kowalczyk Janusz Godlewski Iwona Skwierz-Bogdanska Krzysztof Celinski Tomasz Gach Jan Kulig Bartlomiej Korybalski Zbigniew Kmiec | 2013 | World Journal of Gastroenterology2013，19，27： | 8 |
| 2 | Trogocytosis of CD80 and CD86 by induced regulatory 7 cells显示文摘 | Peng Gu Julia Fang Gao Cheryl A D'Souza Aleksandra Kowalczyk Kuang-Yen Chou Li Zhang | 2012 | Cellular & Molecular Immunology2012，9，2： | 7 |
| 3 | Simulation of Fluid Flow in a Channel Induced by Three Types of Fin-Like Motion显示文摘One of many interesting research activities in biofluidmechanics is dedicated to investigations of locomotion in water. Some of propulsion mechanisms observed in the underwater world are used in the development process of underwater auto-nomic vehicles(AUV). In order to characterise several solutions according to their manoeuvrability,influence on the sur-rounding fluid and energetic efficiency,a detailed analysis of fin-like movement is indispensable. In the current paper an analysis of undulatory,oscillatory and combined fin-like movements by means of numerical simulation is carried out. The conservation equation of mass and the conservation equation of momentum are solved with the Finite Volume Method(FVM) by use of the software CFX-10.0. The undulatory and oscillatory fin movements are modelled with an equation that is implemented within an additional subroutine and joined with the main solver. Numericalsimulations are carried out in the computational domain,in which one fin is fixed in a flow-through water duct. Simulations are carried out in the range of the Re number up to 105. The results show significant influence of applied fin motion on the velocity distribution in the surrounding fluid. | Wojciech Kowalczyk Antonio Delgado | 2007 | Journal of Bionic Engineering2007，4，3： | 4 |
| 4 | Invasion of the raccoon dog Nyctereutes procyonoides in Europe: History of colonization, features behind its success, and threats to native fauna显示文摘 | Kaarina KAUHALA Rafal KOWALCZYK | 2011 | Current Zoology2011，57，5： | 3 |
| 5 | Ultrabroadband wavelength-swept source based on total mode-locking of an Yb:CaF_(2)laser显示文摘We present an ultrabroadband, high-speed wavelength-swept source based on a self-modulated femtosecond oscillator. Photonic crystal fiber was pumped by a mode-locked Yb:CaF2 laser, resulting in a strong spectral broadening from 485 to 1800 nm. The pump laser cavity could be realigned in order to achieve total mode-locking of the longitudinal and transverse TEM00 and TEM01 electromagnetic modes. This led to spatial oscillations of the output beam, which induced modulation of the coupling efficiency to the fiber. Due to the fact that nonlinear spectral broadening was intensity dependent, this mechanism introduced wavelength sweeping at the fiber output. The sweeping rate could be adjusted between 7 and 21.5 MHz by changing the geometry of the pump cavity. By controlling the ratio of the transverse mode amplitudes, we were able to tune the sweeping bandwidth, eventually covering both the 1300 nm and 1700 nm bioimaging transparency windows. When compared with previously demonstrated wavelength-swept sources, our concept offers much broader tunability and higher speed. Moreover,it does not require an additional intensity modulator. | MACIEJ KOWALCZYK TADEUSZ MARTYNKIEN PAWEL MERGO GRZEGORZ SOBON JAROSLAW SOTOR | 2019 | Photonics Research2019，7，2： | 2 |
| 6 | Effect of potassium and barium on the stability of a carbon-supported ruthenium catalyst for the synthesis of ammonia 显示文摘 | Kowalczyk Z Jodzis S Jodzis W | 1998 | Applied Catalysis A:General1998，173，： | 2 |
| 7 | Studies on kinetics of ammonia synthesis over ruthenium catalyst supported on active carbon显示文摘 | Kowalczyk Z Jodzis S Sentek J | 1996 | Applied Catalyst A: General1996，138，： | 2 |
| 8 | Fulminant liver failure following a marathon: Five case reports and review of literature显示文摘BACKGROUND The growing popularity of marathon and half-marathon runs has led to an increased number of patients presenting with exertion-induced heat stroke. Mild hepatic involvement is often observed in these patients;however, fulminant liver failure may occur in approximately 5% of all cases. Liver transplantation is a potentially curative approach for exertion-induced liver failure, although there is a lack of consensus regarding the criteria and optimal timing of this intervention. CASE SUMMARY This paper describes 5 patients (4 men and 1 woman) who were referred to the department where this study was performed with the diagnosis of exertioninduced acute liver failure. Three patients underwent liver transplantation, 1 recovered spontaneously, and 1 patient died on day 11 following the exertion. CONCLUSION Exertion-induced heat stroke may present as fulminant liver failure. These patients may recover with conservative treatment, may require liver transplantation, or may die. No definitive criteria are available to determine patient suitability for a conservative vs surgical approach. | Wojciech Figiel Marcin Morawski Michal Grat Oskar Kornasiewicz Grzegorz Niewiński Joanna Raszeja-Wyszomirska Maciej Krasnodebski Arkadiusz Kowalczyk Waclaw Holówko Waldemar Patkowski Krzysztof Zieniewicz | 2019 | World Journal of Clinical Cases2019，7，12： | 2 |
| 9 | Biofunctionalized upconverting CaF2:Yb,Tm nanoparticles for Candida albicans detection and imaging显示文摘合成方法的万用的优化和 Yb 3+ 和 Tm 3+ 的作文共同做 CaF 2 nanoparticles 以及一个新奇 biofunctionalization 方法被开发并且评估。通过 multistep 合成, Tm 3+ 使活跃之物的光紧张被超过 10 褶层与标准一步舞合成相比提高。建议方法被用来同质地在 nanoparticles 卷以内散布做的离子并且因此减少光熄灭。掺杂物离子集中的优化导致了最有效的可见、在红外线附近的起来变换的 nanoparticles 的选择,它是与 10% Yb 3+ 做的 CaF 20.05% Tm 3+ 和 20% Yb 3+0.5% Tm 3+, 分别地。作为简历标签说明综合 nanoparticles 的适用性,一个奉献 biofunctionalization 方法被使用,并且 nanoparticles 被申请标记并且 Candida albicans 房间的成像。因为依附的分子的存在,这个方法因为极其低的背景和高特性显示出大诺言。 | Malgorzata Misiak Michal Skowicki Tomasz Lipinski Agnieszka Kowalczyk Katarzyna Prorok Sebastian Arabasz Artur Bednarkiewicz | 2017 | Nano Research2017，10，10： | 2 |
| 10 | Alternative Polyadenylation of the Sense Transcript Controls Antisense Transcription of DELAY OF GERMINATION 1 in Arabidopsis显示文摘 | Justyna Kowalczyk Malgorzata Palusinska Agata Wroblewska-Swiniarska Zbigniew Pietras Lukasz Szewc Jakub Dolata Artur Jarmolowski Szymon Swiezewski | 2017 | Molecular Plant2017，10，10： | 2 |
| 11 | In vivo genotoxicity studies with 3-monochloropropan-1,2-diol 显示文摘 | Robjohns S Marshall R Fellows M Kowalczyk G | 2003 | Mutagenesis2003，18，5： | 1 |
| 12 | Simulaneous measurement of allantoin,uric acid,xanthine and hypoxanthine in blood by high-performance liquid chromatography显示文摘 | Czauderna M Kowalczyk J | 1997 | J Chromatogr B1997，704，12： | 1 |
| 13 | Three-color flow cytometry detection of intraceUular cytokines in peripheral blood mononuclear cells : comparative analysis of phorbol myristate acetate-ionomycin and phytohemagglutinin stimulation 显示文摘 | Baran J Kowalczyk D Ozog M | 2001 | Clin Diagn Lab Immunol2001，8，2： | 1 |
| 14 | Anxiety associated with parachute jumping显示文摘 | Kowalczyk E Kura M Ciewierz J | 2012 | Pol Merkur Lekarski2012，33，194： | 1 |
| 15 | Novel acrylic pressure-sensitive adhesive (PSA) containing silver particles显示文摘 | Czech Z Kowalczyk A Shao L | 2013 | Adhes Sci Technol2013，27，13： | 1 |
| 16 | The prognostic value of different glucose abnormalities in patients with acute myocardial infarction treated invasively显示文摘 | Mazurek M Kowalczyk J Lenarczyk R | 2012 | Cardiovasc Diabetol2012，11，： | 1 |
| 17 | Design optimization of cementless femoral hip prostheses using finite element analysis显示文摘 | Kowalczyk P | | 0，，05： | 1 |
| 18 | Photoreactive UV - crosslinkable solvent - free acrylic pressure-sensitive adhesives contai- ning copolymerizable photoinitiators based on benzophenones 显示文摘 | Czech Z Kowalczyk A Kabatc J | 2012 | European Polymer Journal2012，48，8： | 1 |
| 19 | The effect of ascorhic acid protein glycation in streptozotocin-diabetic rats显示文摘 | Gembal M Druzynska J Kowalczyk M Pizepiera E Cybal M Arendarczyk W | 1994 | Diabetologia1994，37，7： | 1 |
| 20 | Full range complex spectral optical coherence tomography technique in eye imaging显示文摘 | Wojtkowski M Kowalczyk A Leitgeb R | 2002 | Optics Letters2002，27，16： | 1 |
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