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| 1 | Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway显示文摘Sclareol,an antifungal specialized metabolite produced by clary sage,Salvia sclarea,is the starting plant natural molecule used for the hemisynthesis of the perfume ingredient ambroxide.Sclareol is mainly produced in clary sage flower calyces;however,the cellular localization of the sclareol biosynthesis remains unknown.To elucidate the site of sclareol biosynthesis,we analyzed its spatial distribution in the clary sage calyx epidermis using laser desorption/ionization mass spectrometry imaging(LDI–FTICR-MSI)and investigated the expression profile of sclareol biosynthesis genes in isolated glandular trichomes(GTs).We showed that sclareol specifically accumulates in GTs’gland cells in which sclareol biosynthesis genes are strongly expressed.We next isolated a glabrous beardless mutant and demonstrate that more than 90%of the sclareol is produced by the large capitate GTs.Feeding experiments,using 1-13 C-glucose,and specific enzyme inhibitors further revealed that the methylerythritol-phosphate(MEP)biosynthetic pathway is the main source of isopentenyl diphosphate(IPP)precursor used for the biosynthesis of sclareol.Our findings demonstrate that sclareol is an MEP-derived diterpene produced by large capitate GTs in clary sage emphasing the role of GTs as biofactories dedicated to the production of specialized metabolites. | Camille Chalvin Stephanie Drevensek Françoise Gilard Caroline Mauve Christel Chollet Halima Morin Edith Nicol Eva Heripre Lucie Kriegshauser Bertrand Gakiere Michel Dron Abdelhafid Bendahmane Adnane Boualem | 2021 | Horticulture Research2021，8，1： | 2 |
| 2 | Signal and construction mechanisms for activation of plant defenses against microbial attack显示文摘 | Lamb C J Lawton M A Dron M | 1989 | Cell1989，56，： | 2 |
| 3 | Evaluation of laparoscopic treatment of common bile duct stones in a prospective series of 505 patients: indications and results显示文摘 | J. Ch. Berthou B. Dron Ph. Charbonneau K. Moussalier L. Pellissier | 2007 | Surgical Endoscopy2007，，11： | 2 |
| 4 | How to account for CO 2 emissions from biomass in an LCA显示文摘 | Ari Rabl Anthony Benoist Dominique Dron Bruno Peuportier Joseph V. Spadaro Assaad Zoughaib | 2007 | The International Journal of Life Cycle Assessment2007，，5： | 2 |
| 5 | Genetic diversity and pathogenic variation of Colletotrichum lindemuthianum in the three centers of diversity of its host, Phaseolus vulgaris 显示文摘 | SICARD D MICHALAKIS Y DRON M | 1997 | Phytopathology1997，87，8： | 1 |
| 6 | A comparative experimental study on the use of three denoising methods for bearing defect detection显示文摘 | DRON J P D RASOLOFONDRAIBE L CHIEMENTIN X | 2010 | Meccanica2010，45，2： | 1 |
| 7 | Visualization of viral candidate cDNAs in infectious brain fractions from Creutzfeldt--Jakob disease by representational difference analysis显示文摘 | Dron M Manuelidis L | 1996 | J Neurovirol1996，2，4： | 1 |
| 8 | Developmental and environmental regulation of a phenylalanine ammonia-lyase-f3-glucuronidase gene fusion in transgenic tobacco plants显示文摘 | Liang X W Dron M Schmid J | 1989 | Proc Nati Acad Sci USA1989，12，： | 1 |
| 9 | Yield and quality of onion flavor oil obtained by supercritical fluid extraction and other methods显示文摘 | DRON A GUYERU D E GAGE D A | 1997 | Journal of Food Process Engineering1997，20，2： | 1 |
| 10 | Signal and construction mechanisms for activation of plant defenses against microbial attack 显示文摘 | Lamb C J Lawton M A Dron M | 1989 | Cell1989，56，： | 1 |
| 11 | Thermodynamic and kinetic approach to the alkali silica reaction Part 2: Experiment显示文摘 | DRON R BRIVOT R | 1993 | Cement and Concrete Research1993，23，4： | 1 |
| 12 | Phenylalanine ammonialyase gene organization and structure显示文摘 | Cramer CL Edwards K Dron M | 1989 | Plant Molecular Biology1989，12，： | 1 |
| 13 | Signal and construction mechanisms for activation of plant defenses against microbial attack显示文摘 | LAMB C J LAWTON M A DRON M DIXON R A | 1989 | Cell1989，56，2： | 1 |
| 14 | Early detection of fatigue damage on rolling element bearings using adapted wavelet 显示文摘 | Chiementin X Bolaers F Dron J P | 2007 | ASME Journal of Vibration and Acoustics2007，129，： | 1 |
| 15 | Signal and constructionmechanisms for activation of plant defenses against microbialatt-ack 显示文摘 | Lamb CJ Lawton MA Dron M Dixon RA | 1989 | Cell1989，56，2： | 1 |
| 16 | Improvement of the sensitivity of the scalar indicators(crest factor,kurtosis)using a de-noising method by spectral subtraction:application to the detection of defects in ball bearings显示文摘 | DRON J P BOLAERS F RASOLOFONDRAIBE L | 2004 | Journal of Sound and Vibration2004，270，1： | 1 |
| 17 | Inheritance of partial resistance against Colletotrichum lindemuthianum in Phaseolus vulgaris and colocalization of quantitative trait loci with genes involved in speciWc resistance 显示文摘 | GeVroy V S~vignac M De Oliveira J C F Fouilloux G Skroch P Thoquet P Gepts P Langin T Dron M | 2000 | Mol Plant Microbe Interact2000，13，： | 1 |
| 18 | Evaluation of laparoseopic treatment of common bile duct stones in a prospective series of 505 patients : indications and results 显示文摘 | Berthou JCh Dron B Charbonneau P | 2007 | Surg Endosc2007，21，11： | 1 |
| 19 | Phenylalanine ammonia-lyase gene organization and structure显示文摘 | Cramer C L Edwards K Dron M | 1989 | Plant Molecular Bioligy1989，12，： | 1 |
| 20 | Clkl, a serine/threonine protein kinase-encoding gene, is involved in pathogenicity of Colletotrichum lindemuthianum on common bean显示文摘 | Dufresne M Bailey JA Dron M | 1998 | MPMI1998，11，： | 1 |
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