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| 1 | Effect of alternative antibiotics in treatment of cefotaxime resistant spontaneous bacterial peritonitis显示文摘AIM:To evaluate effective alternative antibiotics in treatment of cefotaxime-resistant spontaneous bacterial peritonitis.METHODS:One hundred cirrhotic patients with spontaneous bacterial peritonitis [ascitic fluid polymorphonuclear cell count(PMNLs) ≥ 250 cells/mm 3 at admission] were empirically treated with cefotaxime sodium 2 g/12 h and volume expansion by intravenous human albumin.All patients were subjected to history taking,complete examination,laboratory tests(including a complete blood cell count,prothrombin time,biochemical tests of liver and kidney function,and fresh urine sediment),chest X-ray,a diagnostic abdominal paracentesis,and the sample subjected to total and differential cell count,chemical examination,aerobic and anaerobic cultures.Patients were divided after 2 d by a second ascitic PMNL count into group Ⅰ;patients sensitive to cefotaxime(n = 81),group Ⅱ(n = 19);cases resistant to cefotaxime(less than 25% decrease in ascitic PMNL count).Patients of group Ⅱ were randomly assigned into meropenem(n = 11) or levofloxacin(n = 8) subgroups.All patients performed an end of treatment ascitic PMNL count.Patients were considered improved when:PMNLs decreased to < 250 cells/mm 3,no growth in previously positive culture cases,and improved clinical manifestations with at least 5 d of antibiotic therapy.RESULTS:Age,sex,and Child classes showed no significant difference between group Ⅰ and group Ⅱ.Fever and abdominal pain were the most frequent manifestations and were reported in 82.7% and 80.2% of patients in group Ⅰ and in 94.7% and 84.2% of patients in group Ⅱ,respectively.Patients in group Ⅱ had a more severe ascitic inflammatory response than group Ⅰ and this was demonstrated by more ascitic lactate dehydrogenase(LDH) [median:540 IU/L(range:150-1200 IU/L) vs median:240 IU/L(range:180-500 IU/L),P = 0.000] and PMNL [median:15 000 cell/mm 3(range:957-23 822 cell/mm 3) vs 3400 cell/mm 3(range:695-26 400 cell/mm 3),P = 0.000] counts.Ascitic fluid culture was positive in 32% of cases.Cefotaxime failed in 19% of patients;of these patients,11(100%) responded to meropenem and 6(75%) responded to levofloxacin.Two patients with failed levofloxacin therapy were treated according to the in vitro culture and sensitivity(one case was treated with vancomycin and one case was treated with ampicillin/sulbactam).In group Ⅱ the meropenem subgroup had higher LDH(range:108-860 IU/L vs 120-491 IU/L,P = 0.042) and PMNL counts(range:957-23 822 cell/mm 3 vs 957-15 222 cell/mm 3,P = 0.000) at initiation of the alternative antibiotic therapy;there was no significant difference in the studied parameters between patients responsive to meropenem and patients responsive to levofloxacin at the end of therapy(mean ± SD:316.01 ± 104.03PMNLs/mm 3 vs 265.63 ± 69.61 PMNLs/mm 3,P = 0.307).The isolated organisms found in group Ⅱ were;enterococci,acinetobacter,expanded-spectrum β-lactamase producing Escherichia coli,β-lactamase producing Enterobacter and Staphylococcus aureus.CONCLUSION:Empirical treatment with cefotaxime is effective in 81% of cases;meropenem is effective in cefotaxime-resistant cases. | Ahmed Abouelkhair Badawy Tarik Ibrahim Zaher Samar Mahmoud Sharaf Mohamed Hassan Emara Noha Elsaid Shaheen Talaat Fathy Aly | 2013 | World Journal of Gastroenterology2013，19，8： | 13 |
| 2 | 采用低温微波法和电加热法再生载甲苯活性炭显示文摘采用低温微波法(60、120、180 W)和电加热法对载甲苯松木活性炭进行再生。比较了这两种再生方法下活性炭的再生效率、升温速率、能耗,并分析了再生前后活性炭的物理化学性能。结果表明:经过5次吸附—微波辐射再生之后,活性炭吸附量基本保持原有吸附量的45%。随着微波功率从60 W升高到120 W,再生时间从60min降低到22 min,再生效率从1.7%/min增加到4.5%/min。而传统电加热再生法再生时间为180 min,是微波法的3-6倍;功率为60 W的微波加热法的升温速率为178℃/min,而电加热法升温速率只有9℃/min;从能耗角度看,微波再生法的能耗为29.7 k J/g,而电加热法的能耗则为74.3 k J/g;并且经检测微波法再生后活性炭的孔隙结构和官能团未发生改变。 | 冒海燕 周定国 Zaher Hashisho 汪孙国 陈恒 | 2014 | 南京林业大学学报(自然科学版)2014，38，6： | 5 |
| 3 | 微波加热方法制备活化生物质炭的研究显示文摘笔者采用微波加热的方式以松木片为原料、KOH为活化剂制备活化生物质炭,探索了3种不同KOH/生物质炭的配比(0.5、1.5和3.0)条件下的活化生物质炭的孔结构和甲苯吸附量。甲苯吸附量的测试采用了一种简便、高效、环保和廉价的方法。结果表明,配比为3.0的活化生物质炭达到最高的比表面积2044m^2/g,微孔比表面积也达到最高值1712m^2/g。对不同浓度的甲苯进行吸附,在甲苯浓度为400ppmv时,配比为3.0的活化生物质炭显示了最大的吸附量56.0%。而对高浓度甲苯吸附,配比为3.0的活化生物质炭的吸附量则可达到71.9%,并且其吸附等温线数据能很好的拟合DQSAR吸附模型。 | 冒海燕 Zaher Hashisho 汪孙国 陈恒 王海燕 周定国 | 2012 | 林产工业2012，39，3： | 5 |
| 4 | Geochemical and stable isotopic studies of Gulf of Suez’s hot springs,Egypt显示文摘The Gulf of Suez region is one of the most interesting geothermal areas in Egypt because of the high temperatures of its springs.The eastern and western shores of the Gulf of Suez are characterized by superficial thermal manifestations including a cluster of hot springs with varied temperatures.Variations of deuterium and oxygen-18 concentrations in thermal waters have been used to aid in describing the source of recharge in the Gulf of Suez hot springs.Isotope and geochemical data for the Gulf of Suez thermal waters suggest that recharge to the hot springs may not be entirely from the Gulf of Suez water,but possibly from the meteoric water that comes from areas of higher altitude surrounding the hot springs. | Mohamed Abdel Zaher Hakim Saibi Sachio Ehara | 2012 | Chinese Journal Of Geochemistry2012，31，2： | 3 |
| 5 | 新型微波技术再生载甲苯活化秸秆炭显示文摘采用微波加热制备的活化秸秆炭作为吸附剂,通过微波法和电加热法对载甲苯活化秸秆炭进行再生。在确保再生率99%以上的前提下,测定了这两种方法的加热时间、再生效率和能耗等参数。结果表明:经过5次吸附-微波辐射再生之后,吸附量基本保持原有新鲜活化秸秆炭吸附量的为33%;恒功率微波加热法、恒温微波加热法和电加热法所需要的时间分别为1、10和120min;从能耗角度看,微波再生法恒功率(600W)和恒温(150℃)的能耗分别为4.5和9.0kJ/g,而电加热法的能耗则为36kJ/g。因此,微波再生法是一种节能、环保和高效的再生方法,为工业化应用奠定了基础数据。 | 冒海燕 周定国 Zaher Hashisho 汪孙国 陈恒 王海燕 | 2012 | 长安大学学报(自然科学版)2012，32，6： | 3 |
| 6 | Profiling cellular bioenergetics, glutathione levels, and caspase activities in stomach biopsies of patients with upper gastrointestinal symptoms显示文摘AIM: To measure biochemical parameters in stomach biopsies and test their suitability as diagnostic biomarkers for gastritis and precancerous lesions.METHODS: Biopsies were obtained from the stomachs of two groups of patients(n = 40) undergoing fiberoptic endoscopy due to upper gastrointestinal symptoms. In the first group(n = 17), only the corpus region was examined. Biopsies were processed for microscopic examination and measurement of mitochondrial O2 consumption(cellular respiration), cellular adenosine triphosphate(ATP), glutathione(GSH), and caspase activity. In the second group of patients(n = 23), both corpus and antral regions were studied. Some biopsies were processed for microscopic examination, while the others were used for measurements of cellular respiration and GSH level.RESULTS: Microscopic examinations of gastric corpus biopsies from 17 patients revealed normal mucosae in 8 patients, superficial gastritis in 7 patients, and chronic atrophic gastritis in 1 patient. In patients with normal histology, the rate(mean ± SD) of cellular respiration was 0.17 ± 0.02 μmol/L O2 min-1 mg-1, ATP content was 487 ± 493 pmol/mg, and GSH was 469 ± 98 pmol/mg. Caspase activity was detected in 3 out of 8 specimens. The values of ATP and caspase activity were highly variable. The presence of superficial gastritis had insignificant effects on the measured biomarkers. In the patient with atrophic gastritis, cellular respiration was high andATP was relatively low, suggesting uncoupling oxidative phosphorylation. In the second cohort of patients, the examined biopsies showed either normal or superficial gastritis. The rate of cellular respiration(O2. μmol/L min-1 mg-1) was slightly higher in the corpus than the antrum(0.18 ± 0.05 vs 0.15 ± 0.04, P = 0.019). The value of GSH was about the same in both tissues(310 ± 135 vs 322 ± 155, P = 0.692).CONCLUSION: The corpus mucosa was metabolically more active than the antrum tissue. The data in this study will help in understanding the pathophysiology of gastric mucosa. | Ali S Alfazari Bayan Al-Dabbagh Wafa Al-Dhaheri Mazen S Taha Ahmad A Chebli Eva M Fontagnier Zaher Koutoubi Jose Kochiyi Sherif M Karam Abdul-Kader Souid | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 7 | First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases:A 2020 Delphi consensus显示文摘Ulcerative colitis and Crohn’s disease are the main entities of inflammatory bowel disease characterized by chronic remittent inflammation of the gastrointestinal tract.The incidence and prevalence are on the rise worldwide,and the heterogeneity between patients and within individuals over time is striking.The progressive advance in our understanding of the etiopathogenesis coupled with an unprecedented increase in therapeutic options have changed the management towards evidence-based interventions by clinicians with patients.This guideline was stimulated and supported by the Emirates Gastroenterology and Hepatology Society following a systematic review and a Delphi consensus process that provided evidence-and expert opinion-based recommendations.Comprehensive up-to-date guidance is provided regarding diagnosis,evaluation of disease severity,appropriate and timely use of different investigations,choice of appropriate therapy for induction and remission phase according to disease severity,and management of main complications. | Maryam Alkhatry Ahmad Al-Rifai Vito Annese Filippos Georgopoulos Ahmad N Jazzar Ahmed M Khassouan Zaher Koutoubi Rahul Nathwani Mazen S Taha Jimmy K Limdi | 2020 | World Journal of Gastroenterology2020，26，43： | 2 |
| 8 | Spontaneous complete regression of hepatic epithelioid haemangioendothelioma显示文摘 | Zaher K Otrock Aghiad Al-Kutoubi Mireille M Kattar Ghazi Zaatari Assaad Soweid | 2006 | Lancet Oncology2006，，5： | 2 |
| 9 | GP73, a novel Golgi-localized protein upregulated by viral infection显示文摘 | Raleigh D. Kladney Gary A. Bulla Linsheng Guo Andrew L. Mason Ann E. Tollefson Daniela J. Simon Zaher Koutoubi Claus J. Fimmel | 2000 | Gene2000，，1： | 2 |
| 10 | Finite element modeling assumptions impact on seismic response demands of MRF-buildings显示文摘Recent seismic events have raised concerns over the safety and vulnerability of reinforced concrete moment resisting frame 'RC-MRF' buildings. The seismic response of such buildings is greatly dependent on the computational tools used and the inherent assumptions in the modelling process. Thus, it is essential to investigate the sensitivity of the response demands to the corresponding modelling assumption. Many parameters and assumptions are justified to generate effective structural finite element(FE) models of buildings to simulate lateral behaviour and evaluate seismic design demands. As such, the present study focuses on the development of reliable FE models with various levels of refinement. The effects of the FE modelling assumptions on the seismic response demands on the design of buildings are investigated. the predictive ability of a FE model is tied to the accuracy of numerical analysis; a numerical analysis is performed for a series of symmetric buildings in active seismic zones. The results of the seismic response demands are presented in a comparative format to confirm drift and strength limits requirements. A proposed model is formulated based on a simplified modeling approach, where the most refined model is used to calibrate the simplified model. | Shehata E Abdel Raheem Ahmed K Abdel Zaher Ahmed MA Taha | 2018 | Earthquake Engineering and Engineering Vibration2018，17，4： | 2 |
| 11 | Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial显示文摘The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster vaccination.We conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as control.Three groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost.Immunogenicity assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control groups.For Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous booster.Similar results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and Delta.Both heterologous and homologous boosters have a good safety profile.Local and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster schemes.Our findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron. | Nawal Al Kaabi Yun Kai Yang Jing Zhang Ke Xu Yu Liang Yun Kang Ji Guo Su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai Shao Sen Sen Yang Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Ning Liu Fu Jie Shen Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 12 | Re-operation for the Treatment of well Differentiated Thyroid Cancer:Necessity,Safety and Impaction on Further Management显示文摘 | El-Zohairy M Zaher A | 2004 | J Egypt Natl Canc Inst2004，16，3： | 1 |
| 13 | Effect of pulsed dye laser on intercellular adhesion molecule-1 ( ICAM-1 ) expression after treatment of psoriasis显示文摘 | Solimana M Zaher H EI Danasouri N | 2011 | Med- ical Laser Application2011，26，1： | 1 |
| 14 | Nestin expression in the retina of rats with inherited retinal degeneration显示文摘 | Fatemeh Valamanesh Julie Monnin Nadège Morand-Villeneuve Germaine Michel Murhaf Zaher Sofiane Miloudi Deborah Chemouni Jean-Claude Jeanny Claudine Versaux-Botteri | 2013 | Experimental Eye Research2013，，： | 1 |
| 15 | Usefulness of neutrophil to lymphocyte ratioin predicting short- and long-term mortality after non-ST-elevation myocardialinfarclion显示文摘 | Azab B Zaher M Weiserbs KF | 2010 | Am J Cardiol2010，106，4： | 1 |
| 16 | The c-myc x E2F-1/p21 interactive gene expression index augments cytomorphologic diagnosis of lung cancer in fine-needle aspirate specimens显示文摘 | Crawford EL Zaher A | 2003 | J Mol Diagn2003，5，3： | 1 |
| 17 | Enantioselective addition of diethylzinc to aromatic aldehydes catalyzed by Ti (IV) complexes of Cz-symmetrical chiral BINOL derivatives 显示文摘 | Gou S H Zaher M A Judeh | 2008 | Tetrahedron Letters2008，50，： | 1 |
| 18 | On the design of chaos - based secure communication systems 显示文摘 | Zaher A A Abu - Rezq A | 2011 | Communications in Nonlinear Science and Numerical Simulation2011，16，9： | 1 |
| 19 | Circadi- an rhythm of stroke onset during the month of Ramadan 显示文摘 | E1-Mitwalli A Zaher AA E1 Menshawi E | 2010 | Acta Neurol Scand2010，122，2： | 1 |
| 20 | Decreased gene expression of endothelial nitric oxide synthase in newborns with persistent pulmonary hypertension 显示文摘 | Villanueva ME Zaher FM Svinarich OM | 1998 | Pediatr Res1998，44，3： | 1 |
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